Properties and applications of protein-stabilized fluorescent gold nanoclusters: short review
TLDR
In this paper, the strategy for synthesizing fluorescent protein-gold nanoclusters and the characterization methods employed to study these systems are discussed, as well as the promising future for fluorescent protein and gold nanomaterials as long as research continues to uncover fundamental structure-property relation ships.Abstract:
Research is turning toward nanotechnology for solutions to current limitations in bio- medical imaging and analytical detection applications. New to fluorescent nanomaterials that could help advance such applications are protein-stabilized gold nanoclusters. They are potential candidates for imaging agents and sensitive fluorescence sensors because of their biocompat- ibility and intense photoluminescence. This review discusses the strategy for synthesizing fluorescent protein-gold nanoclusters and the characterization methods employed to study these systems. Optical properties and relevant light-emitting applications are reported to present the versatility of protein-gold nanoclusters. These new bio-nano hybrids are an exciting new system that remains to be explored in many aspects, especially regarding the determination of gold nanocluster local structure and the enhancement of quantum yields. Understanding how to finely tune the optical properties will be pivotal for improving fluorescence imaging and other nanocluster applications. There is a promising future for fluorescent protein-gold nanoclusters as long as research continues to uncover fundamental structure-property relation- ships. © 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). (DOI: 10.1117/1.JNP.6read more
Citations
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A Photoluminescent Colorimetric Probe of Bovine Serum Albumin-Stabilized Gold Nanoclusters for New Psychoactive Substances: Cathinone Drugs in Seized Street Samples
TL;DR: The results reveal this BSA-Au NCs probe solution is practical for screening cathinone drugs at crime scenes and was assessed by using it to screen illicit drugs seized by law enforcement officers.
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A multi-responsive intrinsically disordered protein (IDP)-directed green synthesis of fluorescent gold nanoclusters
Rajkamal Balu,Laure Bourgeois,Christopher M. Elvin,Anita J. Hill,Namita Roy Choudhury,Naba K. Dutta +5 more
TL;DR: The green synthesis of fluorescent gold nanoclusters (AuNCs) is demonstrated using a multi-responsive intrinsically disordered protein (IDP) polymer, Rec1-resilin, as amulti-functional template to exclude the use of toxic reducing agents and display excellent water dispersibility, photostability and environmental stability towards aggregation.
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A new "turn-on" fluorescent sensor based on gold quantum dots and silver nanoparticles for lamotrigine detection in plasma.
TL;DR: A simple and rapid method for the quantification of lamotrigine (LTG) was developed using 4-aminothiophenol-stabilized gold quantum dots (4-ATP-AuQDs) and amidosulfonic acid-capped silver nanoparticles (ASA-AgNPs) as a new fluorescence resonance energy transfer (FRET) probe.
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Fluorescent Neoglycoprotein Gold Nanoclusters: Synthesis and Applications in Plant Lectin Sensing and Cell Imaging
TL;DR: The first preparation of neoglycoprotein functionalized fluorescent gold nanoclusters, containing a biantennary N-glycan G0 as targeting molecule, ovalbumin as carrier/model antigen, and a fluorescent gold core as imaging probe (G0-OVA-AuNCs) is described.
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Gold nanoclusters as a quenchable fluorescent probe for sensing oxygen at high temperatures.
TL;DR: Gold nanoclusters capped with lipoic acid (LA) or templated with bovine serum albumin (BSA) are shown to be viable fluorescent probes for oxygen (O2) which acts as a collisional quencher and fluorescence intensity remains constant from 30 to 210 °C and is quenched by O2 following a collisionAL mechanism.
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