Properties and applications of protein-stabilized fluorescent gold nanoclusters: short review
TLDR
In this paper, the strategy for synthesizing fluorescent protein-gold nanoclusters and the characterization methods employed to study these systems are discussed, as well as the promising future for fluorescent protein and gold nanomaterials as long as research continues to uncover fundamental structure-property relation ships.Abstract:
Research is turning toward nanotechnology for solutions to current limitations in bio- medical imaging and analytical detection applications. New to fluorescent nanomaterials that could help advance such applications are protein-stabilized gold nanoclusters. They are potential candidates for imaging agents and sensitive fluorescence sensors because of their biocompat- ibility and intense photoluminescence. This review discusses the strategy for synthesizing fluorescent protein-gold nanoclusters and the characterization methods employed to study these systems. Optical properties and relevant light-emitting applications are reported to present the versatility of protein-gold nanoclusters. These new bio-nano hybrids are an exciting new system that remains to be explored in many aspects, especially regarding the determination of gold nanocluster local structure and the enhancement of quantum yields. Understanding how to finely tune the optical properties will be pivotal for improving fluorescence imaging and other nanocluster applications. There is a promising future for fluorescent protein-gold nanoclusters as long as research continues to uncover fundamental structure-property relation- ships. © 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). (DOI: 10.1117/1.JNP.6read more
Citations
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Noble metal clusters protected with mixed proteins exhibit intense photoluminescence
TL;DR: In this article, the synthesis and detailed mass spectrometric and spectroscopic characterization of highly luminescent Au and Ag clusters protected with mixed proteins was reported. But the authors did not consider the effect of the aggregation tendency of the protein, Lysozyme.
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EGF functionalized polymer-coated gold nanoparticles promote EGF photostability and EGFR internalization for photothermal therapy
Catarina Silva,Steffen B. Petersen,Catarina Pinto Reis,Patrícia Rijo,Jesús Molpeceres,Ana Sofia Fernandes,Odete Gonçalves,Andreia C. Gomes,Isabel Correia,Henrik Vorum,Maria Teresa Neves-Petersen +10 more
TL;DR: The gold nanoparticles conjugated with Epidermal Growth Factor and coated with biopolymers developed in this work, show a potential application for near infrared photothermal therapy, which may efficiently destroy solid tumours, reducing the damage of the healthy tissue.
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Ionic liquid based extraction of flavonoids from Elaeis guineensis leaves and their applications for gold nanoparticles synthesis
Muhammad Irfan,Muhammad Moniruzzaman,Tausif Ahmad,Pradip Chandra Mandal,Sekhar Bhattacharjee,Bawadi Abdullah +5 more
TL;DR: In this paper, an IL-assisted bio-synthesis process was used to synthesize stable gold nanoparticles (AuNPs) using bio-compounds extracted from oil palm leaves (OPL).
Journal ArticleDOI
Natural protein-templated fluorescent gold nanoclusters: Syntheses and applications.
Yahui Guo,Helena T.N.N. Amunyela,Yuliang Cheng,Yunfei Xie,Hang Yu,Weirong Yao,Hung-Wing Li,He Qian +7 more
TL;DR: Prospects were given on utilizing structure-modified proteins, bioactive enzymes, antibodies which should endow the AuNCs more favourable fluorescence performances and functional characteristics and the applications in analytical, biomedical and food sciences would be further heightened.
Journal ArticleDOI
Protein-stabilized gold nanoclusters for PDT: ROS and singlet oxygen generation.
TL;DR: The photoluminescence measurements evidenced the capability of BSA-Au NCs to generate reactive oxygen species upon light exposure, while the observed sensitivity of the photolUMinescence properties might be used to indicate photooxidative processes in the medium.
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