Journal ArticleDOI
Prospect of a stanniocalcin endocrine/paracrine system in mammals.
Kenichi Ishibashi,Masashi Imai +1 more
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TLDR
Interestingly, STC1 and STC2 are expressed in many tumor cell lines, and the expression of STC 2 is enhanced by estradiol in breast cancer cells, suggesting that the biological repertoires of STCs in mammals will be considerably larger than in fish and may not be limited to mineral metabolism.Abstract:
Stanniocalcin (STC) is a calcium- and phosphate-regulating hormone produced in bony fish by the corpuscles of Stannius, which are located close to the kidney. It is a major antihypercalcemic hormon...read more
Citations
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The Multifunctional Fish Gill: Dominant Site of Gas Exchange, Osmoregulation, Acid-Base Regulation, and Excretion of Nitrogenous Waste
TL;DR: The fish gill is a multipurpose organ that, in addition to providing for aquatic gas exchange, plays dominant roles in osmotic and ionic regulation, acid-base regulation, and excretion of nitrogenous wastes.
Journal ArticleDOI
The zebrafish pronephros: A model to study nephron segmentation
TL;DR: The zebrafish model is presented as an excellent genetic system in which to interrogate the conserved developmental pathways that control nephron segmentation in both lower vertebrates and mammals.
Journal ArticleDOI
Evolution and roles of stanniocalcin.
TL;DR: This review integrates the information available on STCs in fish and mammals, focusing mainly on their embryonic origin, tissue distribution, their potential regulatory mechanisms and the modes of action, and their physiological and pathophysiological functions, particularly in cancer biology.
Journal ArticleDOI
Characterization of stanniocalcin 2, a novel target of the mammalian unfolded protein response with cytoprotective properties.
Daisuke Ito,John R. Walker,Charlie S. Thompson,Isabella Moroz,William Lin,Margaret Veselits,Antoine M. Hakim,Allen A. Fienberg,Gopal Thinakaran +8 more
TL;DR: Stanniocalcin 2 (STC2), a mammalian homologue of a calcium- and phosphate-regulating hormone first identified in fish, is described as a novel target of the unfolded-protein response (UPR) and induced STC2 expression is an essential feature of survival component of the UPR.
Journal ArticleDOI
Mammalian stanniocalcins and cancer.
TL;DR: There is a positive correlation between the level of expression of estrogen receptor and expression of both STC1 and STC2 in breast cancer, and the roles they may play in normal physiology and in breast and other cancers are discussed.
References
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Journal ArticleDOI
The transcriptional program in the response of human fibroblasts to serum.
Vishwanath R. Iyer,Michael B. Eisen,Douglas T. Ross,Greg Schuler,Troy Moore,Jeffrey C. Lee,Jeffrey M. Trent,Louis M. Staudt,James I. Hudson,Mark S. Boguski,Deval A. Lashkari,Dari Shalon,David Botstein,Patrick O. Brown +13 more
TL;DR: The temporal program of gene expression during a model physiological response of human cells, the response of fibroblasts to serum, was explored with a complementary DNA microarray representing 8600 different human genes.
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Relationship between trinucleotide repeat expansion and phenotypic variation in Huntington's disease
Russell G. Snell,J C MacMillan,Jeremy Peter Cheadle,I. Fenton,L. P. Lazarou,Peter Davies,Marcy E. MacDonald,James F. Gusella,Peter S. Harper,D.J. Shaw +9 more
TL;DR: The molecular analysis of a specific CAG repeat sequence in the Huntington's disease gene reveals a range of 30–70 repeats in affected individuals and 9–34 in normals, which suggests that normal gene function varies because of the size of the repeat in the normal range and a sex–specific modifying effect.
Journal Article
Effects of estrogen on global gene expression : Identification of novel targets of estrogen action
April Charpentier,Andrzej K. Bednarek,Rachael L. Daniel,Kathleen A. Hawkins,Kendra J. Laflin,Sara S. Gaddis,Michael C. MacLeod,C. Marcelo Aldaz +7 more
TL;DR: Serial analysis of gene expression on estrogen-responsive breast cancer cells after exposure to this hormone provides a comprehensive view of the changes induced by E2 on the transcriptional program of human E2-responsive cells, and identifies novel and previously unsuspected gene targets whose expression is affected by this hormone.
Journal ArticleDOI
A novel human cDNA highly homologous to the fish hormone stanniocalcin
Andy C.-M. Chang,Jackie B.M. Janosi,Miriam Hulsbeek,Debora de Jong,Katherine J. Jeffrey,Jane R. Noble,Roger R. Reddel +6 more
TL;DR: It is concluded that a human protein similar to the fish hormone is expressed in multiple tissues rather than by a specialized endocrine organ.
Journal ArticleDOI
Human stanniocalcin: A possible hormonal regulator of mineral metabolism
Henrik S. Olsen,Mario A. Cepeda,Qing Qing Zhang,Craig A. Rosen,Benito L. Vozzolo,Graham F. Wagner +5 more
TL;DR: A human cDNA clone encoding the mammalian homolog of stanniocalcin (STC), a calcium- and phosphate-regulating hormone that was first described in fishes where it functions in preventing hypercalcemia is isolated.