Journal ArticleDOI
Protective effect of volatile oil, alcoholic and aqueous extracts of Origanum majorana on lead acetate toxicity in mice.
TLDR
It could be concluded that O. majorana plays an important role in ameliorating liver and kidney functions and genotoxicity induced by lead toxicity.Abstract:
Natural dietary antioxidants are extensively studied for their ability to protect cells from miscellaneous damages. Origanum majorana L., Lamiaceae, is a potent antioxidant. The effect of administration of O. majorana (volatile oil, alcoholic and aqueous extracts) on oral administration of lead acetate in the diet of mice at concentration 0.5% (W/W) for one month were studied by measuring serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), urea and creatinine, histopathological changes of the liver and kidney and genotoxicity including, rate of micronucleus and chromosomal aberrations in bone marrow cells. Mice were treated with the 3 different forms of O. majorana, one month before and maintained with lead acetate administration. The 3 forms of O. majorana induced a significant decrease in serum activities of transaminases (AST & ALT), ALP, urea and creatinine and improved the liver and kidney histology in comparison with lead acetate treated group. Alcoholic extracts of O. majorana significantly reduced the rate of micronucleus, number of aberrant cells and different kinds of chromosomal aberrations. Volatile oil extract significantly reduced the rate of micronucleus and chromosomal fragments. Aqueous extract and volatile oil also of O. majorana significantly reduced number of gaps, ring chromosome and stickiness. It could be concluded that O. majorana plays an important role in ameliorating liver and kidney functions and genotoxicity induced by lead toxicity.read more
Citations
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Journal ArticleDOI
Investigation of the antioxidant behavior of air- and freeze-dried aromatic plant materials in relation to their phenolic content and vegetative cycle.
TL;DR: The total phenolic and flavonoid content of the aerial parts of five aromatic plants harvested at different periods was estimated, and their antioxidant capacity was evaluated, and the amount of identified phenolic acids did not vary considerably within the investigated year.
Journal ArticleDOI
Comparative effects of Artemisia dracunculus, Satureja hortensis and Origanum majorana on inhibition of blood platelet adhesion, aggregation and secretion
TL;DR: In addition to alternation of cell adhesive properties, self aggregation and protein secretion of the treated platelets were also affected upon treatment with the crude methanol extracts, which provide the basis for the traditional use of these herbs in treatments of cardiovascular diseases and thrombosis.
Journal ArticleDOI
Effects of marjoram volatile oil and grape seed extract on ethanol toxicity in male rats.
TL;DR: Marjoram volatile oil and grape seed extract are useful herbal remedies, especially for controlling oxidative damages, and co-administration of the extracts of protective plants resulted in minimizing the hazard effects of ethanol toxicity on male fertility, liver and brain tissues.
Journal ArticleDOI
Effects of carvacrol on defects of ischemia-reperfusion in the rat liver.
Mediha Canbek,Mustafa Uyanoglu,Gokhan Bayramoglu,Hakan Senturk,Nilüfer Erkasap,Tülay Köken,Sema Uslu,Canan Demirüstü,Erinc Aral,K. Hüsnü Can Başer +9 more
TL;DR: The comparative effects of carvacrol in the liver of rats subjected to ischemia-reperfusion defect, with silymarin are investigated, and it is concluded that carVacrol protects the liver against defects caused by ischemIA and reperfusion, and car vacrol is not hepatotoxic at the applied dosage.
Journal ArticleDOI
Amelioration of prallethrin-induced oxidative stress and hepatotoxicity in rat by the administration of Origanum majorana essential oil.
TL;DR: Prallethrin caused oxidative damage and liver injury in male rat and co-administration of EO attenuated the toxic effect of prallethrin, demonstrating that administration of Eo may be useful, easy, and economical to protect human against pyrethroids toxic effects.
References
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Journal ArticleDOI
A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases.
Stanley Reitman,Sam Frankel +1 more
Journal ArticleDOI
Estimation of Plasma Phosphatase by Determination of Hydrolysed Phenol with Amino-antipyrine
P. R. N. Kind,E. J. King +1 more
TL;DR: The conditions under which enzymic hydrolysis is carried out are the same as in the King-Armstrong method, as modified by King (1951), the amino-antipyrine reagent (A.A.P.) being used to estimate the phenol liberated.
Book
Encyclopedia of Common Natural Ingredients: Used in Food, Drugs, and Cosmetics
Albert Y. Leung,Steven Foster +1 more
TL;DR: In this article, the authors present an overview of natural ingredients and their applications in the field of chemical engineering, including the following categories: Natural Ingredients, Chemical Index, and Chemical Index.
Journal ArticleDOI
Spectrophotometric and kinetics investigation of the Berthelot reaction for the determination of ammonia
TL;DR: The role and identity of the "catalyst" for the Berthelot reaction are examined in detail in detail as mentioned in this paper, and a new procedure for ammonia analysis which is superior in both sensitivity and precision to the other published procedures is presented.
Book ChapterDOI
The Micronucleus Test for Cytogenetic Analysis
TL;DR: Micronuclei originate from chromatin which for different reasons has been lagging in anaphase, and in the course of telophase this material is included into one or the other daughter cell where it either can fuse with the main nucleus or form one or several secondary nuclei.