Proteomics as the tool to search for lung disease markers in bronchoalveolar lavage
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TLDR
The significance of the use of proteome analysis of BAL fluid for the search for new lung disease marker proteins and for their simultaneous display and analysis in patients suffering from lung disorders has been examined.Abstract:
Most lung disorders are known to be associated to considerable modifications of surfactant composition Numerous of these abnormalities have been exploited in the past to diagnose lung diseases, allowing proper treatment and follow-up Diagnosis was then based on phospholipid content, surface tension and cytological features of the epithelial lining fluid (ELF), sampled by bronchoalveolar lavage (BAL) during fiberoscopic bronchoscopy Today, it appears that the protein content of ELF displays a remarkably high complexity, not only due to the wide variety of the proteins it contains but also because of the great diversity of their cellular origins The significance of the use of proteome analysis of BAL fluid for the search for new lung disease marker proteins and for their simultaneous display and analysis in patients suffering from lung disorders has been examinedread more
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Human body fluid proteome analysis
TL;DR: The proteomics technologies currently used for global identification and quantification of body fluid proteins are summarized, and the putative biomarkers discovered for a variety of human diseases through human body fluid proteome (HBFP) analysis are elaborate.
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Shui Qing Ye,Brett A. Simon,James P. Maloney,April Zambelli-Weiner,Li Gao,Audrey V. Grant,R. Blaine Easley,Bryan J. McVerry,Rubin M. Tuder,Theodore J. Standiford,Roy G. Brower,Kathleen C. Barnes,Joe G.N. Garcia +12 more
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Differential Proteomic Analysis of Bronchoalveolar Lavage Fluid in Asthmatics following Segmental Antigen Challenge
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