Pulmonary Toxicity Following an Intratracheal Instillation of Nickel Oxide Nanoparticle Agglomerates
Yasuo Morimoto,Masami Hirohashi,Akira Ogami,Takako Oyabu,Toshihiko Myojo,Masayoshi Hashiba,Yohei Mizuguchi,Tatsunori Kambara,Byeong Woo Lee,Etsushi Kuroda,Isamu Tanaka +10 more
Reads0
Chats0
TLDR
Pulmonary Toxicity Following an Intratracheal Instillation of Nickel Oxide Nanoparticle Agglomerates: Yasuo Morimoto, et al.Abstract:
Pulmonary Toxicity Following an Intratracheal Instillation of Nickel Oxide Nanoparticle Agglomerates: Yasuo M ori M oto , et al. Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan— Objective: We examined the pulmonary toxicity of nickel oxide nanoparticle agglomerates in the rat lung following an intratracheal instillation. Methods: The weighted average surface primary diameter of nickel oxide nanoparticles was 8.41 nm, and the count median diameter of nickel oxide nanoparticle agglomerates suspended in saline was 1.34 µm. Male Wistar rats were exposed to 1 mg (3.3 mg/kg) of nickel oxide nanoparticles intratracheally. The control group received intratracheal instillation of saline. Rats were dissected 3 days, 1 wk, 1 mo, 3 mo, and 6 mo after the instillation. Cytokine-induced neutrophil chemoattractant (CINC)- 2αβ in the lung tissue was determined by quantitative measurement of protein by ELISA. Results: The total cell count in bronchoalveolar lavage fluid (BALF) was increased persistently from 3 days to 6 mo. The neutrophil counts in BALF were also increased at 3 days, 1 wk, 3 mo, and 6 mo. In the lung tissue, infiltration of mainly neutrophils and alveolar macrophages was observed in alveoli from 3 days to 6 mo. The CINC-2αβ concentration was elevated from 3 days to 6 mo in the lung tissue. Conclusions: These results showed that micron-sized nickel oxide nanoparticle agglomerates also induced a persistent inflammatory response. (J Occup Health 2011; 53: 293-295)read more
Citations
More filters
Journal ArticleDOI
Genotoxicity and carcinogenicity of cobalt-, nickel- and copper-based nanoparticles (Review)
TL;DR: This review intends to summarize the current knowledge on the genotoxic and carcinogenic potential of cobalt-, nickel- and copper-based nanoparticles indicated in in vitro and in vivo mammalian studies and include studies that have reported epigenetic factors involving these nanoparticles.
Journal ArticleDOI
Nickel oxide nanoparticles exert cytotoxicity via oxidative stress and induce apoptotic response in human liver cells (HepG2).
TL;DR: This is the first report demonstrating that NiO NPs caused cytotoxicity via ROS and induced apoptosis in HepG2 cells, which is likely to be mediated through bax/bcl-2 pathway.
Journal ArticleDOI
Nickel oxide nanoparticles induce inflammation and genotoxic effect in lung epithelial cells
TL;DR: Nickel oxide nanoparticles toxicity has been evaluated in the human pulmonary epithelial cell lines and their ability in inducing DNA damage responses has been demonstrated, confirming the cytotoxic and pro-inflammatory potential of NiONPs.
Journal ArticleDOI
Recent progress in studies of metallic nickel and nickel-based nanoparticles' genotoxicity and carcinogenicity.
Ruth Magaye,Jinshun Zhao +1 more
TL;DR: This mini-review intends to summarize the current knowledge on the genotoxicity and carcinogenicity potential of metallic nickel and nickel-based nanoparticles implicated in in vitro and in vivo mammalian studies.
Journal ArticleDOI
Magnetic nanovectors for drug delivery
TL;DR: This review will assess the most recent developments and current status of magnetically responsive nanoparticles (MNP) that are composed of one or more of the three elements that are ferromagnetic at physiological temperature: nickel, cobalt and iron.
References
More filters
Journal ArticleDOI
Comparative pulmonary toxicity study of nano-TiO2 particles of different sizes and agglomerations in rats: Different short- and long-term post-instillation results
TL;DR: Two intratracheal instillation experiments with nano-size titanium dioxide (TiO(2) particles of different sizes and agglomerations were conducted in rats to compare the biological responses induced by the different particles, indicating that both short- and long-term effects should be evaluated when assessing the toxicity of nanoparticles.
Journal ArticleDOI
Pathological features of different sizes of nickel oxide following intratracheal instillation in rats.
Akira Ogami,Yasuo Morimoto,Toshihiko Myojo,Takako Oyabu,Masahiro Murakami,Motoi Todoroki,Kenichiro Nishi,Chikara Kadoya,Makoto Yamamoto,Isamu Tanaka +9 more
TL;DR: Analysis of morphological and qualitative changes over time in the development of inflammation and collagen deposition in lung tissue after intratracheal instillation of two sizes of nickel oxide in rats suggested that submicrometer nano-nickel oxide is associated with greater toxicity, as for crystalline silica, than micrometer-sized nickel oxide.
Journal ArticleDOI
Hazard Assessments of Manufactured Nanomaterials
Yasuo Morimoto,Norihiro Kobayashi,Naohide Shinohara,Toshihiko Myojo,Isamu Tanaka,Junko Nakanishi +5 more
TL;DR: Hazard Assessments of Manufactured Nanomaterials: Yasuo Morimoto, et al.
Journal ArticleDOI
Expression of inflammation-related cytokines following intratracheal instillation of nickel oxide nanoparticles
Yasuo Morimoto,Akira Ogami,Motoi Todoroki,Makoto Yamamoto,Masahiro Murakami,Masami Hirohashi,Takako Oyabu,Toshihiko Myojo,Kenichiro Nishi,Chikara Kadoya,Sayumi Yamasaki,Hiroko Nagatomo,Katsuhide Fujita,Shigehisa Endoh,Kunio Uchida,Kazuhiro Yamamoto,Norihiro Kobayashi,Junko Nakanishi,Isamu Tanaka +18 more
TL;DR: It was suggested that nano-agglomerates of nickel oxide nanoparticles have a persistent inflammatory effect, and the transient increase in cytokine expression and persistent increases in CC chemokine were involved in the persistent pulmonary inflammation.
Journal ArticleDOI
Expression of cytokine-induced neutrophil chemoattractant in rat lungs by intratracheal instillation of nickel oxide nanoparticles.
Kenichiro Nishi,Yasuo Morimoto,Akira Ogami,Masahiro Murakami,Toshihiko Myojo,Takako Oyabu,Chikara Kadoya,Makoto Yamamoto,Motoi Todoroki,Masami Hirohashi,Sayumi Yamasaki,Katsuhide Fujita,Shigehisa Endo,Kunio Uchida,Kazuhiro Yamamoto,Junko Nakanishi,Isamu Tanaka +16 more
TL;DR: The results suggest that CINC was involved in lung injury by nickel oxide nanoparticles, and three chemokines in the lung tissue and bronchoalveolar lavage fluid were determined by quantitative measurement of protein by ELISA.