Open AccessJournal Article
Pulmonary toxicity of antineoplastic agents.
TLDR
Pulmonary parenchymal or pleural reactions to chemotherapeutic agents used in the management of patients with malignant diseases are being recognized with increasing frequency and appear to be direct toxic effects of the drugs.Abstract:
Pulmonary parenchymal or pleural reactions to chemotherapeutic agents used in the management of patients with malignant diseases are being recognized with increasing frequency. Alkylating agents, asparaginase, bleomycin, methotrexate and procarbazine have all been implicated. Some of the reactions, such as the rare procarbazine pleuritis and pneumonitis, represent hypersensitivity phenomena. Others, such as alkylating agent pulmonary toxicity, appear to be direct toxic effects of the drugs. The severity of the toxicity is variable. The appearance of these pulmonary changes must be differentiated from tumor progression or a variety of possible infections. The awareness of possible pulmonary toxicity is of great importance since early discontinuation of the agent following the first hint of pulmonary toxicity may allow partial or complete reversal of the process. Continued therapy in the face of drug-related pulmonary toxicity may enhance the likelihood of irreversible pulmonary compromise with respiratory failure and death.read more
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Methotrexate pneumonitis: review of the literature and histopathological findings in nine patients
TL;DR: It is important that all patients receiving methotrexate be educated concerning this potential adverse reaction and instructed to contact their physicians should significant new pulmonary symptoms develop while undergoing therapy, and if metotrexate pneumonitis is suspected, methotRexate should be discontinued.
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Pulmonary complications in survivors of childhood and adolescent cancer. A report from the Childhood Cancer Survivor Study.
Ann C. Mertens,Yutaka Yasui,Yan Liu,Marilyn Stovall,Ray Hutchinson,Jill P. Ginsberg,Charles A. Sklar,Leslie L. Robison +7 more
TL;DR: The Childhood Cancer Survivor Study is a resource that was designed to investigate long‐term effects among 5‐year survivors of childhood and adolescent malignancies.
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Education, employment, insurance, and marital status among 694 survivors of pediatric lower extremity bone tumors: a report from the childhood cancer survivor study.
Rajaram Nagarajan,M.P.H. Joseph P. Neglia M.D.,Denis R. Clohisy,Yutaka Yasui,Mark Greenberg,Melissa M. Hudson,Michael A. Zevon,Jean M. Tersak,Arthur Ablin,Leslie L. Robison +9 more
TL;DR: Psychosocial outcomes (education, employment, health insurance, and marriage) for survivors of pediatric lower extremity bone tumors are described.
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Chemotherapy-induced lung disease
TL;DR: The diagnosis of chemotherapy-associated lung disease remains an exclusionary process, particularly with respect to considering usual and atypical infections, as well as recurrence of the underlying neoplastic process in these immune compromised patients.
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Immunologic lung disease.
TL;DR: In 1972, McCombs published an elegant review of diseases due to immunologic reactions in the lungs, and intense interest in pulmonary immunology has provided new insights into the role of immunology.