Open AccessJournal Article
Quantitative assay of 5,5-diphenylhydantoin (Dilantin) and 5-(p-hydroxyphenyl)-5-phenylhydantoin by gas-liquid chromatography.
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This article is published in Journal of Laboratory and Clinical Medicine.The article was published on 1970-01-01 and is currently open access. It has received 88 citations till now.read more
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Quantitative estimation of diphenylhydantoin, primidone and phenobarbital in plasma by gas-liquid chromatography.
TL;DR: A gas-liquid Chromatographic method for the simultaneous determination of phenobarbital, primidone and diphenylhydantoin in human plasma following therapeutic doses has been developed and has the advantages of specificity, sensitivity and simple derivative formation.
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Usefulness of Blood Levels of Antiepileptic Drugs
TL;DR: Monitoring the blood levels of anti-epileptic drugs has increased the efficiency and safety of drug therapy in epilepsy, and facilitates individualization of dosage regimen, reveals irregular drug intake, and identifies the responsible agent in intoxicated patients on multiple drug therapy.
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Valproic acid in epilepsy: clinical and pharmacological effects.
TL;DR: The antiepileptic drug valproic acid was studied in an open clinical trial as adjunct medication for 23 patients with uncontrolled seizures of a generalized or partial type and two‐thirds of the patients experienced reduction in seizure frequency.
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Effect of diphenylhydantoin on insulin secretion in man.
TL;DR: It is demonstrated that DPH, known to inhibit insulin release in vitro, also diminished insulin response to an intensive and sustained glucose stimulation in man, and should be used with special caution in patients who have a risk of diabetes.
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Diphenylhydantoin elimination kinetics in overdosed children.
TL;DR: The time of onset of D PH toxicity in the children was related to the magnitude by which the rate of DPH administration exceeded the Vmax values, and patients with higher V max values had greater urinary excretion rates of HPPH which, at high serum levels of DP H, were relatively constant except jor an apparent diurnal rhythm.