Journal ArticleDOI
Quinolinic acid: a potent endogenous excitant at amino acid receptors in CNS.
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This article is published in European Journal of Pharmacology.The article was published on 1981-07-10. It has received 716 citations till now. The article focuses on the topics: Quinolinic acid & Amino acid.read more
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A Meta-Analysis of Cytokines in Major Depression
Yekta Dowlati,Nathan Herrmann,Nathan Herrmann,Walter Swardfager,Walter Swardfager,Helena Liu,Lauren Sham,Elyse K. Reim,Krista L. Lanctôt,Krista L. Lanctôt +9 more
TL;DR: A meta-analysis of studies measuring cytokine concentration in patients with major depression reports significantly higher concentrations of the proinflammatory cytokines TNF-alpha and IL-6 in depressed subjects compared with control subjects, strengthening evidence that depression is accompanied by activation of the IRS.
Journal ArticleDOI
Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus.
TL;DR: Results indicate that the synaptic receptor in the Schaffer collateral‐commissural pathway may be of the kainate or quisqualate type and although NMA receptors do not appear to be involved in normal synaptic transmission in this pathway they may play a role in synaptic plasticity.
Journal ArticleDOI
Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain
TL;DR: Intracerebral injection of the neuroexcitatory tryptophan metabolite, quinolinic acid, has behavioral, neurochemical and neuropathological consequences reminiscent of those of exogenous excitotoxins, such as kainic and ibotenic acids.
Journal ArticleDOI
Kynurenines in the mammalian brain: when physiology meets pathology
TL;DR: With recently developed pharmacological agents, it is now possible to restore metabolic equilibrium and envisage novel therapeutic interventions on the basis of the kynurenine pathway.
Journal ArticleDOI
Pathways underlying neuroprogression in bipolar disorder : focus on inflammation, oxidative stress and neurotrophic factors
Michael Berk,Flávio Kapczinski,Ana Cristina Andreazza,Ana Cristina Andreazza,Olivia M Dean,Olivia M Dean,Francesco Giorlando,Francesco Giorlando,Michael Maes,Murat Yücel,Clarissa Severino Gama,Seetal Dodd,Seetal Dodd,Brian Dean,Brian Dean,Pedro Vieira da Silva Magalhães,Pedro Vieira da Silva Magalhães,G. Paul Amminger,Patrick D. McGorry,Gin S Malhi +19 more
TL;DR: Emerging data shows that these biomarkers may differ between early and late stages of BD in parallel with stage-related structural and neurocognitive alterations, which facilitates identification of rational therapeutic targets, and the development of novel treatment classes.
References
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Journal ArticleDOI
Phosphonate analogues of carboxylic acids as aminoacid antagonists on rat cortical neurones.
TL;DR: The results support the view that a distinct population of receptors exists which are preferentially activated by NMDA.
Journal ArticleDOI
Biosynthesis in vitro of homarine and pyridine carboxylic acids in marine shrimp.
J.C. Netherton rd,S. Gurin +1 more
TL;DR: Proper procedures have been developed for the satisfactory separation of N-methyl quinolinate from homarine in the in vitro system.