Journal ArticleDOI
Radiolysis of tetrachloromethane
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TLDR
In this article, a mechanism for the radiolysis of tetrachloromethane is proposed, based on spin-traps, which can detect the formation of radical adducts.Abstract:
Electron spin resonance studies of tetrachloromethane after exposure to 60Co γ-rays at 77 K reveal the formation of ·CCl3 and CCl˙+4 radicals. On warming in the presence of spin-traps, or on irradiating fluid solutions, nitroxide radical adducts have been detected that are characteristic of ·CCl3 and chlorine atom adducts. In the light of this evidence and that of other investigators a mechanism for the radiolysis of tetrachloromethane is postulated.In the presence of oxygen, ·CCl3 radicals are converted into Cl3COO· radicals. The use of spin-traps to detect these radicals is described and evaluated.read more
Citations
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Journal ArticleDOI
Spin trapping: ESR parameters of spin adducts.
TL;DR: In this article, the electron spin resonance hyperfine splitting constants of spin adducts of interest in this area are tabulated and a brief comment on the source of the radical trapped is given.
Journal ArticleDOI
Biochemical studies on the metabolic activation of halogenated alkanes.
TL;DR: The experimental approaches that are used to establish that halogenated alkanes are metabolized in animal tissues to reactive free radicals are described.
Book ChapterDOI
Nitroxide Radical Adducts in Biology: Chemistry, Applications, and Pitfalls
Carolyn Mottley,Ronald P. Mason +1 more
TL;DR: Spin trapping is a technique in which a reactive free radical reacts with a double bond of a diamagnetic compound, the spin trap, to form a less reactive freeradical.
Journal ArticleDOI
Applications of electron spin resonance spectroscopy to the identification of radicals produced during lipid peroxidation.
TL;DR: This review examines a variety of different xenobiotic systems and tissues and summarises the information obtained from these studies, with particular reference to the elucidation of the nature of the radicals involved in the initiation and propagation of lipid peroxidation.
Journal ArticleDOI
Mechanism of the lethal interaction of chlordecone and CCl4 at non-toxic doses
TL;DR: A model where prior exposure to non-toxic levels of the pesticide Kepone (chlordecone) results in a 67-fold amplification of CCl4 lethality in experimental animals is developed and a novel hypothesis for the mechanism of chlordecones amplification of halomethane toxicity and lethality is proposed.