Journal ArticleDOI
Re: The Cumulative Burden of Surviving Childhood Cancer: An Initial Report from the St Jude Lifetime Cohort Study (SJLIFE).
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This article is published in The Journal of Urology.The article was published on 2018-06-01. It has received 119 citations till now. The article focuses on the topics: Cohort study.read more
Citations
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Journal ArticleDOI
Safety of combining radiotherapy with immune-checkpoint inhibition.
TL;DR: Data from numerous retrospective series and a handful of prospective studies provide burgeoning evidence that the combination of palliative radiotherapy and ICI is safe overall without a substantial site-specific increase in adverse events.
Journal ArticleDOI
Major Cardiac Events for Adult Survivors of Childhood Cancer Diagnosed Between 1970 and 1999: Report From the Childhood Cancer Survivor Study Cohort
Daniel A. Mulrooney,Geehong Hyun,Kirsten K. Ness,Matthew J. Ehrhardt,Yutaka Yasui,Daniel Duprez,Rebecca M. Howell,Wendy M. Leisenring,Louis S. Constine,Emily S. Tonorezos,Todd M. Gibson,Leslie L. Robison,Kevin C. Oeffinger,Melissa M. Hudson,Gregory T. Armstrong +14 more
TL;DR: Historical reductions in exposure to cardiac radiation have been associated with a reduced risk of coronary artery disease among adult survivors of childhood cancer, particularly among survivors of Hodgkin lymphoma.
Journal ArticleDOI
Broad Spectrum Activity of the Checkpoint Kinase 1 Inhibitor Prexasertib as a Single Agent or Chemopotentiator Across a Range of Preclinical Pediatric Tumor Models
Caitlin D. Lowery,Michele Dowless,Matthew Renschler,Wayne Blosser,Alle B VanWye,Jennifer R. Stephens,Philip W. Iversen,Aimee Bence Lin,Richard P. Beckmann,Kateryna Krytska,Kristina A. Cole,John M. Maris,Douglas S. Hawkins,Brian P. Rubin,Raushan T. Kurmasheva,Peter J. Houghton,Richard Gorlick,E. Anders Kolb,Min H. Kang,C. Patrick Reynolds,Stephen W. Erickson,Beverly A. Teicher,Malcolm A. Smith,Louis Stancato +23 more
TL;DR: Pediatric sarcoma cell lines were highly sensitive to prexasertib treatment in vitro, resulting in activation of the DNA damage response, and concurrent administration with chemotherapy was sufficient to overcome innate resistance or prevent acquired resistance toPrex asertib in preclinical models of neuroblastoma, osteosarcoma, and Ewing sarcomA, or alveolar rhabdomyosar coma.
Journal ArticleDOI
Mechanisms of Anthracycline-Induced Cardiotoxicity: Is Mitochondrial Dysfunction the Answer?
TL;DR: How anthracyclines affect cardiac mitochondria and how these organelles contribute to AIC is described and how drugs specifically targeting mitochondrial dysfunction and/or mitochondria-targeted drugs could be therapeutically exploited to treat AIC are discussed.
Journal ArticleDOI
Fertility preservation options in pediatric and adolescent patients with cancer
TL;DR: A review examines the indications for consultation, male and female FP options both in the prepubertal patient and adolescent patient, and the unique ethical issues surrounding FP in this vulnerable population of survivors of childhood cancer.
References
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Journal ArticleDOI
Safety of combining radiotherapy with immune-checkpoint inhibition.
TL;DR: Data from numerous retrospective series and a handful of prospective studies provide burgeoning evidence that the combination of palliative radiotherapy and ICI is safe overall without a substantial site-specific increase in adverse events.
Journal ArticleDOI
Major Cardiac Events for Adult Survivors of Childhood Cancer Diagnosed Between 1970 and 1999: Report From the Childhood Cancer Survivor Study Cohort
Daniel A. Mulrooney,Geehong Hyun,Kirsten K. Ness,Matthew J. Ehrhardt,Yutaka Yasui,Daniel Duprez,Rebecca M. Howell,Wendy M. Leisenring,Louis S. Constine,Emily S. Tonorezos,Todd M. Gibson,Leslie L. Robison,Kevin C. Oeffinger,Melissa M. Hudson,Gregory T. Armstrong +14 more
TL;DR: Historical reductions in exposure to cardiac radiation have been associated with a reduced risk of coronary artery disease among adult survivors of childhood cancer, particularly among survivors of Hodgkin lymphoma.
Journal ArticleDOI
Broad Spectrum Activity of the Checkpoint Kinase 1 Inhibitor Prexasertib as a Single Agent or Chemopotentiator Across a Range of Preclinical Pediatric Tumor Models
Caitlin D. Lowery,Michele Dowless,Matthew Renschler,Wayne Blosser,Alle B VanWye,Jennifer R. Stephens,Philip W. Iversen,Aimee Bence Lin,Richard P. Beckmann,Kateryna Krytska,Kristina A. Cole,John M. Maris,Douglas S. Hawkins,Brian P. Rubin,Raushan T. Kurmasheva,Peter J. Houghton,Richard Gorlick,E. Anders Kolb,Min H. Kang,C. Patrick Reynolds,Stephen W. Erickson,Beverly A. Teicher,Malcolm A. Smith,Louis Stancato +23 more
TL;DR: Pediatric sarcoma cell lines were highly sensitive to prexasertib treatment in vitro, resulting in activation of the DNA damage response, and concurrent administration with chemotherapy was sufficient to overcome innate resistance or prevent acquired resistance toPrex asertib in preclinical models of neuroblastoma, osteosarcoma, and Ewing sarcomA, or alveolar rhabdomyosar coma.
Journal ArticleDOI
Mechanisms of Anthracycline-Induced Cardiotoxicity: Is Mitochondrial Dysfunction the Answer?
TL;DR: How anthracyclines affect cardiac mitochondria and how these organelles contribute to AIC is described and how drugs specifically targeting mitochondrial dysfunction and/or mitochondria-targeted drugs could be therapeutically exploited to treat AIC are discussed.
Journal ArticleDOI
Fertility preservation options in pediatric and adolescent patients with cancer
TL;DR: A review examines the indications for consultation, male and female FP options both in the prepubertal patient and adolescent patient, and the unique ethical issues surrounding FP in this vulnerable population of survivors of childhood cancer.