Reduced Mycobacterium tuberculosis association with monocytes from diabetes patients that have poor glucose control
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TLDR
An altered route of entry of the pathogen in DM patients that may influence the downstream activation of signaling pathways in the monocyte and the survival of mycobacteria is suggested.About:
This article is published in Tuberculosis.The article was published on 2013-03-01 and is currently open access. It has received 83 citations till now.read more
Citations
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Journal ArticleDOI
Immunological mechanisms contributing to the double burden of diabetes and intracellular bacterial infections
Kelly A. Hodgson,Jodie L. Morris,Tahnee L. Bridson,Brenda Govan,Catherine M. Rush,Natkunam Ketheesan +5 more
TL;DR: The convergence of intracellular bacterial infections and diabetes poses new challenges for immunologists, providing the impetus for multidisciplinary research.
Journal ArticleDOI
Diabetes and immunity to tuberculosis.
Nuria Martinez,Hardy Kornfeld +1 more
TL;DR: In this article, the authors provide an update on the clinical and epidemiological features of tuberculosis in the diabetic population and relate them to recent advances in understanding the mechanistic basis of tuberculosis susceptibility and other complications of diabetes.
Journal ArticleDOI
Influence of diabetes mellitus on immunity to human tuberculosis.
Pavan Kumar Nathella,Subash Babu +1 more
TL;DR: Current findings regarding the alterations in the innate and adaptive immune responses and immunological mechanisms of susceptibility of patients with DM to M. tuberculosis infection and disease are summarized.
Journal ArticleDOI
Diabetes and Tuberculosis.
TL;DR: This chapter summarizes the current epidemiological, clinical, and immunological knowledge on TB and DM and their clinical and public health implications, including the underlying mechanisms for TB risk in DM patients and theirclinical and sociodemographic characteristics that distinguish them from TB patients without DM.
References
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Journal ArticleDOI
Standards of Medical Care in Diabetes—2010
TL;DR: These standards of care are intended to provide clinicians, patients, researchers, payors, and other interested individuals with the components of diabetes care, general treatment goals, and tools to evaluate the quality of care.
Journal ArticleDOI
Enhancing CD8 T-cell memory by modulating fatty acid metabolism.
Erika L. Pearce,Matthew C. Walsh,Paloma Cejas,Gretchen M. Harms,Hao Shen,Li-San Wang,Russell G. Jones,Yongwon Choi +7 more
TL;DR: It is shown that tumour necrosis factor (TNF) receptor-associated factor 6 (TRAF6), an adaptor protein in the TNF-receptor and interleukin-1R/Toll-like receptor superfamily, regulates CD8 TM-cell development after infection by modulating fatty acid metabolism.
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Diabetes Mellitus Increases the Risk of Active Tuberculosis: A Systematic Review of 13 Observational Studies
Christie Y. Jeon,Megan Murray +1 more
TL;DR: DM was associated with an increased risk of TB regardless of study design and population and efforts to diagnose, detect, and treat DM may have a beneficial impact on TB control.
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Tests of Glycemia in Diabetes
David E. Goldstein,Randie R. Little,Rodney A. Lorenz,John I. Malone,David M. Nathan,Charles M. Peterson,David B. Sacks +6 more
TL;DR: The purpose of this review is to summarize current knowledge about the tests used most widely in monitoring the glycemic status of people with diabetes, and it includes tests of urine glucose and ketones and tests of blood glucose and glycated proteins (hemoglobin and serum proteins).
Journal ArticleDOI
Molecular Organization and Function of the Complement System
TL;DR: The purpose of this presentation is to provide a chronology of events leading up to and including the creation of the C3 Convertase, as well as some of the key players in the development of the Convertase.
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Diabetes Mellitus Increases the Risk of Active Tuberculosis: A Systematic Review of 13 Observational Studies
Christie Y. Jeon,Megan Murray +1 more