Journal ArticleDOI
Regional functional recovery after acute myocardial infarction: a cardiac magnetic resonance long-term study
Agnes Mayr,Kathrin Pedarnig,Gert Klug,Michael Schocke,Otmar Pachinger,Werner Jaschke,Bernhard Metzler +6 more
TLDR
Improvement of SWT occurred exclusively within the first 4 months after acute myocardial infarction and remained unchanged thereafter and is related to rapid revascularization of the infarct-related artery and the absence of microvascular obstruction.Abstract:
We sought to analyze the trend of functional recovery after successful reperfused ST-elevation myocardial infarction (STEMI) in an optimally treated patient group over a 14 month follow-up in relation to ischemia-time and the presence of microvascular obstruction (MVO). First-pass perfusion-, cine- and late enhancement (LE)- cardiac MR were performed in 40 patients (33 male and 7 female, 54.8 ± 12.3 years) within 6 days as well as 4 and 14 months after successful primary percutaneous coronary intervention for STEMI. Significant recovery of segmental wall thickening (SWT %) occurred exclusively in infarcted segments reperfused within 4 h after symptom onset (group 1 with pain-to-balloon time <2 h: 59 ± 4 to 70 ± 4%; P < 0.02) (group 2 with pain-to-balloon-time 2–4 h: 51 ± 4 to 59 ± 3%, P < 0.05) during the first 4 months, whereas changes thereafter were not significant (P = NS). Infarcted segments with MVO showed lowest regional myocardial function at any time of assessment (all P < 0.001) and a lack of significant recovery during the study period. Significant recovery of regional myocardial function is related to rapid revascularization of the infarct-related artery and the absence of MVO. Improvement of SWT occurred exclusively within the first 4 months after acute myocardial infarction and remained unchanged thereafter.read more
Citations
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Journal ArticleDOI
Prognostic value at 5 years of microvascular obstruction after acute myocardial infarction assessed by cardiovascular magnetic resonance
Gert Klug,Agnes Mayr,Sonja Schenk,Regina Esterhammer,Michael Schocke,Michael Nocker,Werner Jaschke,Otmar Pachinger,Bernhard Metzler +8 more
TL;DR: Early MVO, as assessed by first-pass CMR, is an independent long-term prognosticator for morbidity after AMI.
Journal ArticleDOI
Assessing myocardial recovery following ST-segment elevation myocardial infarction: short- and long-term perspectives using cardiovascular magnetic resonance
Gert Klug,Bernhard Metzler +1 more
TL;DR: The currently available data on the use of CMR after acute STEMI is discussed, a brief look at developing new methods currently under investigation are taken and more specific methods such as magnetic resonance relaxometry, myocardial tagging, 4D phase-contrast imaging and novel superparamagnetic contrast agents are emerging.
Journal ArticleDOI
Prognosis-based definition of left ventricular remodeling after ST-elevation myocardial infarction
Martin Reindl,Sebastian J. Reinstadler,Christina Tiller,Hans-Josef Feistritzer,Markus Kofler,Alexandra Brix,Agnes Mayr,Gert Klug,Bernhard Metzler +8 more
TL;DR: Following revascularized STEMI, %∆LVEDV ≥ 10% showed strongest association with clinical outcome, suggesting this criterion as preferred CMR-based definition of post-STEMI LV remodeling.
Journal ArticleDOI
Role of Cardiac Magnetic Resonance to Improve Risk Prediction Following Acute ST-Elevation Myocardial Infarction.
TL;DR: An overview of the current impact of CMR imaging on optimized risk assessment soon after acute ST-elevation myocardial infarction is provided.
References
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Standardized Myocardial Segmentation and Nomenclature for Tomographic Imaging of the Heart A Statement for Healthcare Professionals From the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association
Manuel D. Cerqueira,Neil J. Weissman,Vasken Dilsizian,Alice K. Jacobs,Sanjiv Kaul,Warren K. Laskey,Dudley J. Pennell,John A. Rumberger,Thomas J. Ryan,Mario S. Verani +9 more
TL;DR: Attempts to standardize options for all cardiac imaging modalities should be based on the sound principles that have evolved from cardiac anatomy and clinical needs, and selection of standardized methods must bebased on the following criteria.
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Myocardial infarction redefined--a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction.
Elliott M. Antman,Jean-Pierre Bassand,Werner Klein,Magnus Ohman,José Luis López Sendón,Lars Rydén,Maarten L. Simoons,Michal Tendera +7 more
TL;DR: In this paper, the authors defined the definition of MI and established the following criteria for acute, evolving or recent MI: 1) Typical rise and gradual fall (troponin) or more rapid rise and fall (CK-MB) of biochemical markers of myocardial necrosis with at least one of the following: a) ischemic symptoms; b) development of pathologic Qwaves on the ECG; c) ECG changes indicative of ischemia (ST segment elevation or depression); or d) coronary artery intervention (e.g., coronary ang
Journal ArticleDOI
Standardized Myocardial Segmentation and Nomenclature for Tomographic Imaging of the Heart
Manuel D. Cerqueira,Neil J. Weissman,Vasken Dilsizian,Alice K. Jacobs,Sanjiv Kaul,Warren K. Laskey,Dudley J. Pennell,John A. Rumberger,Thomas J. Ryan,Mario S. Verani +9 more
TL;DR: A remarkable committee was convened: The American Heart Association Writing Group on Myocardial Segmentation and Registration for Cardiac Imaging came to an agreement upon all aspects of nomenclature and anatomic descriptions of the heart.
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The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction.
Raymond J. Kim,Edwin Wu,Allen Rafael,Enn-Ling Chen,Michele Parker,Orlando P. Simonetti,Francis J. Klocke,Robert O. Bonow,Robert M. Judd +8 more
TL;DR: Reversible myocardial dysfunction can be identified by contrast-enhanced MRI before coronary revascularization and is strongly related to the degree of improvement in the global mean wall-motion score and the ejection fraction after Revascularization.
Journal ArticleDOI
Myocardial infarction redefined - A consensus document of the Joint European Society of Cardiology/American College of Cardiology committee for the redefinition of myocardial infarction
Joseph S. Alpert,Elliott M. Antman,Fred S. Apple,Paul W. Armstrong,J. P. Bassand,A. B. De Luna,George A. Beller,Günter Breithardt,Bernard R. Chaitman,Peter Clemmensen,Erling Falk,Michael C. Fishbein,Marcello Galvani,A Jr Garson,Cindy L. Grines,Christian W. Hamm,B. Nauheim,Uta C. Hoppe,Allan S. Jaffe,Hugo A. Katus,J. Kjeksus,Werner Klein,P. Klootwijk,C. Lenfant,Daniel Levy,R. I. Levy,Russell V. Luepker,F. Marcus,Ulf Näslund,Magnus Ohman,O. Pahlm,P. A. Poole-Wilson,R. Popp,Kalevi Pyörälä,Jan Ravkilde,N. Rehnquist,W. Roberts,Robert Roberts,J. Roelandt,Lars Rydén,Susana Sans,M. L. Simoons,Kristian Thygesen,Hugh Tunstall-Pedoe,Richard Underwood,Barry F. Uretsky,F. Van de Werf,L. M. Voipio-Pulkki,Galen S. Wagner,Lars Wallentin,William Wijns,David R. Wood +51 more
TL;DR: Biochemical markers of myocardial necrosis may have normalized, depending on the length of time that has passed since the infarct developed, and one of the following criteria satisfies the diagnosis for established MI: development of new pathologic Q waves on serial ECGs.