Journal ArticleDOI
Regulation of phosphofructokinase by phosphocreatine and phosphorylated glycolytic intermediates.
TLDR
Evidence found in the literature suggests that inhibition in vitro of P-fructokinase by these compounds plays a role in regulation of glycolysis.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 1969-03-31. It has received 132 citations till now. The article focuses on the topics: Phosphofructokinase & Glycolysis.read more
Citations
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ATP and brain function
Maria Erecińska,Ian A. Silver +1 more
TL;DR: In the brain, the brain is one of the organs that is particularly sensitive to lack of oxygen and in humans at rest is responsible for 20% of total O2 consumption, even though it accounts for only 2% of the body weight.
Journal ArticleDOI
Brain lactate metabolism: the discoveries and the controversies.
TL;DR: Most evidence supports glucose as the major fuel for normal, activated brain, and Synaptosomes from the adult brain and many preparations of cultured neurons have high capacities to increase glucose transport, glycolysis, and glucose-supported respiration, and pathway rates are stimulated by glutamate and compounds that enhance metabolic demand.
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Cerebral carbohydrate metabolism during acute hypoxia and recovery.
TL;DR: Levels of ATP, ADP, AMP and phosphocreatine were normal or near normal even when convulsions and respiratory collapse appeared imminent and Glycogen decreased and lactate rose markedly in hypoxia.
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Skeletal muscle metabolism during short duration high-intensity exercise: influence of creatine supplementation
TL;DR: Seven male subjects performed repeated bouts of high-intensity exercise, on a cycle ergometer, before and after 6 d of creatine supplementation (20 g Cr H2O day-1) and there was no change in jump performance as a result of the creatine supplementation.
References
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Journal ArticleDOI
Effect of Ischemia on Known Substrates and Cofactors of the Glycolytic Pathway in Brain
TL;DR: This is a record of the concentrations of the nonenzyme components of the Embden-Meyerhof system in mouse brain measured at brief intervals after the production of complete ischemia by decapitation, which resulted in increases in glycolytic rates of at least 4to 7-fold in different experimental groups of mice.
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Citrate as an Intermediary in the Inhibition of Phosphofructokinase in Rat Heart Muscle by Fatty Acids, Ketone Bodies, Pyruvate, Diabetes and Starvation
TL;DR: Observations suggest that anoxia and uncouplers of respiratory chain phosphorylation increase the rate of the phosphofructokinase reaction in muscle (and hence of glycolysis) by increasing the concentrations of 5′ AMP, ADP and inorganic phosphate and diminishing that of ATP.
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Kinetic evidence for multiple binding sites on phosphofructokinase.
TL;DR: The kinetic findings have been interpreted to indicate the presence of not less than seven substrate, inhibitor, and deinhibitor sites (and possibly as many as 12) in the formulation of P-fructokinase, and it would appear that these sites are so arranged that the addition of one inhibitor (ATP) makes it easier to add the other
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Regulatory Mechanisms in Carbohydrate Metabolism VII. HEXOKINASE AND PHOSPHOFRUCTOKINASE
Kosaku Uyeda,Efraim Racker +1 more