Journal ArticleDOI
Regulation of tissue architecture and stem cell dynamics to sustain homeostasis and repair in the skin epidermis.
TLDR
In this article, a review on the skin epidermis is presented, focusing on how tissue architecture is generated during development, maintained through adult life, and re-established during regeneration.About:
This article is published in Seminars in Cell & Developmental Biology.The article was published on 2021-09-23. It has received 1 citations till now. The article focuses on the topics: Biology & Stem cell.read more
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Book ChapterDOI
Parallels in signaling between development and regeneration in ectodermal organs.
TL;DR: In this article , the development and morphogenesis of ectodermal organs are regulated by a set of common signaling pathways, such as Shh, Wnt, Bmp, Notch, Tgf-β, and Eda.
References
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Journal ArticleDOI
Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing.
TL;DR: Tumors of epithelioma are composed of two discrete but interdependent compartments: the malignant cells themselves and the stroma that they induce and in which they are dispersed.
Journal ArticleDOI
High burden and pervasive positive selection of somatic mutations in normal human skin
Inigo Martincorena,Amit Roshan,Moritz Gerstung,Peter R. Ellis,Peter Van Loo,Peter Van Loo,Peter Van Loo,Stuart McLaren,David C. Wedge,Anthony Fullam,Ludmil B. Alexandrov,Jose M. C. Tubio,Lucy Stebbings,Andrew Menzies,Sara Widaa,Michael R. Stratton,Philip H. Jones,Peter J. Campbell,Peter J. Campbell +18 more
TL;DR: Across 234 biopsies of sun-exposed eyelid epidermis from four individuals, the burden of somatic mutations averaged two to six mutations per megabase per cell, similar to that seen in many cancers, and exhibited characteristic signatures of exposure to ultraviolet light.
Journal ArticleDOI
Three clonal types of keratinocyte with different capacities for multiplication
Yann Barrandon,Howard Green +1 more
TL;DR: Colony-forming human epidermal cells are heterogeneous in their capacity for sustained growth and the incidence of the different clonal types is affected by aging, since cells originating from the epidermis of older donors give rise to a lower proportion of holoclones and a higher proportion of paraclones.
Journal ArticleDOI
Permanent Coverage of Large Burn Wounds with Autologous Cultured Human Epithelium
G. Gregory Gallico,G. Gregory Gallico,Nicholas E. O'Connor,Nicholas E. O'Connor,Carolyn C. Compton,Carolyn C. Compton,Olaniyi Kehinde,Olaniyi Kehinde,Howard Green,Howard Green +9 more
TL;DR: A new source of autograft must be found to provide wound coverage in burns when burns are so extensive that skin grafts obtainable from remaining donor sites are insufficient to provide wounds coverage.
Journal ArticleDOI
Epidermal homeostasis: a balancing act of stem cells in the skin.
Cédric Blanpain,Elaine Fuchs +1 more
TL;DR: Interestingly, the basic mechanisms and signalling pathways that orchestrate epithelial morphogenesis in the skin are reused during adult life to regulate skin homeostasis.