Ophir D. Klein

TL;DR: It is found that complete loss of the Lgr5-expressing cells did not perturb homeostasis of the epithelium, indicating that other cell types can compensate for the elimination of this population, and that in the absence of these cells, Bmi1- expressing cells can serve as an alternative stem cell pool.

TL;DR: This work presents the complete three-dimensional branching pattern and lineage of the mouse bronchial tree, reconstructed from an analysis of hundreds of developmental intermediates, and proposes that each mode of branching is controlled by a genetically encoded subroutine, a series of local patterning and morphogenesis operations, which are themselvescontrolled by a more global master routine.

TL;DR: It is shown that HLOs are remarkably similar to human fetal lung based on global transcriptional profiles, suggesting that HL Os are an excellent model to study human lung development, maturation and disease.

TL;DR: The Collaborative Cross Consortium reports here on the development of a unique genetic resource population, a multiparental recombinant inbred panel derived from eight laboratory mouse inbred strains, which shows that founder haplotypes are inherited at the expected frequency.

TL;DR: It is demonstrated that MSCs originate from periarterial cells and are regulated by Shh secretion from an NVB, which is found that NVB sensory nerves secrete Shh protein, which activates Gli1 expression in periartersia that contribute to all mesenchymal derivatives.