Journal ArticleDOI
Relation of central obesity and insulin resistance with high diabetes prevalence and cardiovascular risk in South Asians.
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TLDR
The results confirm the existence of an insulin resistance syndrome, prevalent in South Asian populations and associated with a pronounced tendency to central obesity in this group, and control of obesity and greater physical activity offer the best chances for prevention of diabetes and CHD.About:
This article is published in The Lancet.The article was published on 1991-02-16. It has received 1643 citations till now. The article focuses on the topics: Insulin resistance & Diabetes mellitus.read more
Citations
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Obesity as a medical problem
TL;DR: The global epidemic of obesity results from a combination of genetic susceptibility, increased availability of high-energy foods and decreased requirement for physical activity in modern society, and should be regarded as an epidemic that threatens global well being.
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Global Burden of Cardiovascular Diseases Part I: General Considerations, the Epidemiologic Transition, Risk Factors, and Impact of Urbanization
TL;DR: An overview of the global burden of atherothrombotic cardiovascular disease is provided and overarching factors influencing variations in CVD by ethnicity and region and the influence of urbanization are described.
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Physical illness in patients with severe mental disorders.I. Prevalence, impact of medications and disparities in health care
Marc De Hert,Christoph U. Correll,Julio Bobes,Marcelo Cetkovich-Bakmas,Dan Cohen,Itsuo Asai,Johan Detraux,S. Gautam,Hans-Jurgen Möller,David M. Ndetei,John W. Newcomer,Richard Uwakwe,Stefan Leucht +12 more
TL;DR: Prevalence rates of different physical illnesses as well as important individual lifestyle choices, side effects of psychotropic treatment and disparities in health care access, utilization and provision that contribute to these poor physical health outcomes are reported.
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In utero programming of chronic disease
TL;DR: This review examines the evidence linking these diseases to fetal undernutrition and provides an overview of previous studies in this area.
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Predicting cardiovascular risk in England and Wales: prospective derivation and validation of QRISK2.
Julia Hippisley-Cox,Carol Coupland,Yana Vinogradova,John Robson,Rubin Minhas,Aziz Sheikh,Peter Brindle +6 more
TL;DR: In this paper, the authors developed and validated version two of the QRISK cardiovascular disease risk algorithm (QRISK2) to provide accurate estimates of cardiovascular risk in patients from different ethnic groups in England and Wales and to compare its performance with the modified version of Framingham score recommended by the National Institute for Health and Clinical Excellence (NICE).
References
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Role of Insulin Resistance in Human Disease
TL;DR: The possibility is raised that resistance to insulin-stimulated glucose uptake and hyperinsulinemia are involved in the etiology and clinical course of three major related diseases— NIDDM, hypertension, and CAD.
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Relation of Body Fat Distribution to Metabolic Complications of Obesity
TL;DR: In women, the sites of fat predominance offer an important prognostic marker for glucose intolerance, hyperinsulinemia, and hypertriglyceridemia, may be related to the disparate morphology and metabolic behavior of fat cells associated with different body fat distributions.
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Distribution of adipose tissue and risk of cardiovascular disease and death: a 12 year follow up of participants in the population study of women in Gothenburg, Sweden.
TL;DR: The relation between the ratio of waist to hip circumference and the end points of myocardial infarction, angina pectoris, stroke, and death was stronger than for any other anthropometric variable studied.
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Central obesity and coronary heart disease in men
TL;DR: Central obese individuals are at increased risk of CHD, independent of BMI, because of the relationship between central body fat distribution and SSF.
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Diabetes incidence in Pima indians: contributions of obesity and parental diabetes.
TL;DR: In the Pimas, both obesity and diabetes have become more common during this century, perhaps as a result of rapid cultural and dietary changes in a population genetically susceptible to diabetes.