Journal ArticleDOI
Relation of frequency and severity of mitral regurgitation to survival among patients with left ventricular systolic dysfunction and heart failure.
Benjamin H. Trichon,G. Michael Felker,Linda K. Shaw,Christopher H. Cabell,Christopher M. O'Connor +4 more
TLDR
MR was found to be an independent predictor of mortality after multivariable analysis and present in those with ischemic and nonischemic cardiomyopathies who underwent cardiac catheterization between 1986 and 2000.Abstract:
The goal of this study was to examine the frequency of mitral regurgitation (MR) in patients with left ventricular (LV) systolic dysfunction and to relate its presence and severity to long-term survival Remodeling of the left ventricle after myocyte injury leads to a progressive change in LV size and shape, and it may lead to the development of MR The frequency of MR and its relation to survival in patients with LV systolic dysfunction has not been completely characterized We analyzed the histories, coronary anatomy, and degree of MR in patients with symptomatic heart failure and LV ejection fraction <40% who underwent cardiac catheterization between 1986 and 2000 Cox's proportional hazards modeling was used to assess the independent effect of MR on survival Two thousand fifty-seven patients met study criteria; MR was common in this cohort (562%) Of patients with MR, 811 (701%) had mild (grades 1+ or 2+) and 345 (298%) had moderate or severe (grades 3+ or 4+) regurgitation Survival rates at 1, 3, and 5 years were significantly lower in patients with moderate to severe MR versus those with mild or no MR (p <0001) MR was found to be an independent predictor of mortality after multivariable analysis (hazards ratio 123, 95% confidence interval 113 to 134, p = 00001) This relation of MR and survival was present in those with ischemic and nonischemic cardiomyopathies MR is common in patients with LV systolic dysfunction and heart failure After adjusting for other clinical variables, the presence of MR independently predicted worsened survivalread more
Citations
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2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease
Rick A. Nishimura,Catherine M Otto,Robert O. Bonow,Blase A. Carabello,John P. Erwin,Robert A. Guyton,Patrick T. O'Gara,Carlos E. Ruiz,Nikolaos J. Skubas,Paul Sorajja,Thoralf M. Sundt,James D. Thomas +11 more
TL;DR: The medical profession should play a central role in evaluating evidence related to drugs, devices, and procedures for detection, management, and prevention of disease.
Journal ArticleDOI
Guidelines on the management of valvular heart disease The Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology
Alec Vahanian,Helmut Baumgartner,Jeroen J. Bax,Butchart Eg,Robert Dion,Gerasimos Filippatos,Frank A. Flachskampf,Roger Hall,Bernard Iung,Jarosław D. Kasprzak,Patrick Nataf,Pilar Tornos,Lucia Torracca,Arnold Wenink,Silvia G. Priori,Jean-Jacques Blanc,Andrzej Budaj,John Camm,Veronica Dean,Jaap W. Deckers,Kenneth Dickstein,John Lekakis,Keith McGregor,Marco Metra,João Morais,Ady Osterspey,Juan Tamargo,José Luis Zamorano,Annalisa Angelini,Manuel J. Antunes,Miguel Ángel García Fernández,Christa Gohlke-Baerwolf,Gilbert Habib,John J.V. McMurray,Catherine M Otto,Luc Pierard,José L. Pomar,Bernard Prendergast,Raphael Rosenhek,Miguel Sousa Uva +39 more
TL;DR: Guidelines and Expert Consensus Documents aim to present management recommendations based on all of the relevant evidence on a particular subject in order to help physicians select the best possible management strategies for the individual patient suffering from a specific condition, taking into account the impact on outcome and also the risk–benefit ratio of a particular diagnostic or therapeutic procedure.
Journal ArticleDOI
Guidelines on the management of valvular heart disease (version 2012)
Alec Vahanian,Ottavio Alfieri,Felicita Andreotti,Manuel J. Antunes,Gonzalo Barón-Esquivias,Helmut Baumgartner,Michael A. Borger,Thierry Carrel,Michele De Bonis,Arturo Evangelista,Volkmar Falk,Bernard Iung,Patrizio Lancellotti,Luc Pierard,Susanna Price,Hans-Joachim Schäfers,Gerhard Schuler,Janina Stępińska,Karl Swedberg,Johanna J.M. Takkenberg,Ulrich O. von Oppell,Stephan Windecker,José Luis Zamorano,Marian Zembala +23 more
TL;DR: Guidelines summarize and evaluate all evidence available on a particular issue with the aim of assisting physicians in selecting the best management strategies for an individual patient with a given condition, taking into account the impact on outcome.
Journal ArticleDOI
2017 AHA/ACC Focused Update of the 2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines
Rick A. Nishimura,Catherine M Otto,Robert O. Bonow,Blase A. Carabello,John P. Erwin,Lee A. Fleisher,Hani Jneid,Michael J. Mack,Christopher J. McLeod,Patrick T. O'Gara,Vera H. Rigolin,Thoralf M. Sundt,Annemarie Thompson +12 more
TL;DR: In this article, Levine and O'Gara proposed a new chairperson for FAHA, who was elected by a majority of the FAHA board members, including Birtcher, Bozkurt and Halperin.
Journal ArticleDOI
2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines
Rick A. Nishimura,Catherine M Otto,Robert O. Bonow,Blase A. Carabello,John P. Erwin,Robert A. Guyton,Patrick T. O'Gara,Carlos E. Ruiz,Nikolaos J. Skubas,Paul Sorajja,Thoralf M. Sundt,James D. Thomas +11 more
TL;DR: In this paper, Anderson and Halperin proposed a new FAHA chair, named Jeffrey L. Anderson, MD, FACC, FAHA, Chair-Elect, Nancy M. Albert and Biykem Bozkurt.
References
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Journal ArticleDOI
ACC/AHA Guidelines for the Management of Patients With Valvular Heart Disease A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Patients With Valvular Heart Disease)
RobertO. Bonow,Blase A. Carabello,AntonioC. de Leon,L. Henry Edmunds,BradleyJ. Fedderly,MichaelD. Freed,WilliamH. Gaasch,CharlesR. McKay,RickA. Nishimura,PatrickT. O’Gara,RobertA. O’Rourke,ShahbudinH. Rahimtoola,JamesL. Ritchie,MelvinD. Cheitlin,KimA. Eagle,TimothyJ. Gardner,Arthur Garson,R. J. Gibbons,RichardO. Russell,ThomasJ. Ryan,SidneyC. Smith +20 more
TL;DR: It is important that the medical profession play a significant role in critically evaluating the use of diagnostic procedures and therapies in the management or prevention of disease states.
Journal Article
ACC/AHA Guidelines for the Management of Patients With Valvular Heart Disease. Executive Summary. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Patients With Valvular Heart Disease).
Robert O. Bonow,Blase A. Carabello,A. C. de Leon,L. H. Edmunds,Bradley J. Fedderly,Michael D. Freed,William H. Gaasch,Charles R. McKay,Rick A. Nishimura,Patrick T. O'Gara,Robert A. O'Rourke,S.H. Rahimtoola,James L. Ritchie,Melvin D. Cheitlin,K. A. Eagle,Timothy J. Gardner,A. Garson,R. J. Gibbons,R. O. Russell,Thomas J. Ryan,Sidney C. Smith +20 more
Journal ArticleDOI
Regression Models in Clinical Studies: Determining Relationships Between Predictors and Response
TL;DR: This paper addresses the latter assumption of the distribution of the response variable by applying a direct and flexible approach, cubic spline functions, to two widely used models: the logistic regression model for binary responses and the Cox proportional hazards regression models for survival time data.
Journal ArticleDOI
Left retrograde cardioangiography in acquired cardiac disease: Technic, indications and interpretations in 700 cases∗
TL;DR: Application of retrograde left cardioangiography to 700 patients, both adults and children, with acquired valvular diseases is described, and the value of this information in the surgical management of many forms of cardiac disease is emphasized.
Journal ArticleDOI
Advantages and applications of the centerline method for characterizing regional ventricular function
Florence H. Sheehan,Edward L. Bolson,Harold T. Dodge,Detlef G. Mathey,Joachim Schofer,Hok-Wai Woo +5 more
TL;DR: The severity of hypokinesis at the site of acute myocardial infarction correlated better with infarct size estimated from creatine kinase release than did the ejection fraction or the circumferential extent of hypkinesis.