Open AccessJournal Article
Relationship between radiographic features and bone mineral density in elderly men.
TLDR
The radiographic features of lumbar disc degeneration, anterior osteophytes, and end plate sclerosis were associated with an increase in BMD at the spine, and there was a strong negative correlation in terms of age at the femoral neck, though not at the backbone.Abstract:
Lumbar disc degeneration is characterised radiologically by the presence of osteophytes, endplate sclerosis, and disc space narrowing. Our study was designed to assess anterior lumbar osteophytes, disc space narrowing, end plate sclerosis, and bone mineral density (BMD) in the lumbar vertebrae and femoral neck of elderly men. A total of 1000 men, aged between 71 and 90 years, were invited to participate in the study. BMD was assessed at the spine and femoral neck using dual energy X-ray absorptiometry (DXA). We examined the relationship with the degree of lumbar spinal and femoral neck deformity by using the Z-score. Lateral and anterioposterior spinal radiographs were evaluated for features of lumbar disc degeneration. The observers consisted of a consultant physical therapist, a radiologist, and anatomists who together studied the series of radiographs. Anterior lumbar osteophytes (grade 0-3), end-plate sclerosis, and disc space narrowing (grade 0-2) were evaluated. The Pearson correlation test was used to determine the association between radiographic features, the lumbar mineral density (LBMD), and femoral neck mineral density (FNBMD). In all, 90.6% of lumbar vertebral levels showed evidence of anterior osteophytes, 87.5% showed evidence of end plate sclerosis, and 68.2% of disc space narrowing. Additionally, there was a strong negative correlation in terms of age at the femoral neck, though not at the spine. On the other hand, there was a significant correlation between osteophyte grade and end plate sclerosis at the spine. In our study, the radiographic features of lumbar disc degeneration, anterior osteophytes, and end plate sclerosis were associated with an increase in BMD at the spine.read more
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Manual therapy regulates oxidative stress in aging rat lumbar intervertebral discs through the SIRT1/FOXO1 pathway
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Divergent Significance of Bone Mineral Density Changes in Aging Depending on Sites and Sex Revealed through Separate Analyses of Bone Mineral Content and Area
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References
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Journal Article
A longitudinal study of the effect of spinal degenerative disease on bone density in the elderly.
TL;DR: Bone density at the femoral neck was much less affected by spinal degenerative disease, which suggests that this site may be more efficacious for both monitoring response to treatment and determining fracture risk in the elderly.
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Impact of degenerative spinal diseases on bone mineral density of the lumbar spine in elderly women
Shigeyuki Muraki,Seizo Yamamoto,Hideaki Ishibashi,Toshiyuki Horiuchi,Takayuki Hosoi,Hajime Orimo,Kozo Nakamura +6 more
TL;DR: Femoral neck BMD may be more appropriate than lumbar spine BMD in evaluating osteoporosis in elderly women, as multiple regression analysis indicated that the scores for osteophyte formation, bone sclerosis, and disk space narrowing were independently correlated with lumbr spine B MD.
Journal ArticleDOI
Allelic variation in the vitamin D receptor, lifestyle factors and lumbar spinal degenerative disease.
TL;DR: Both genetic and lifestyle factors were associated with the presence and severity of spinal degenerative disease in this elderly sample of 110 men and 172 women over 60 years of age.
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Association of transforming growth factor β1 genotype with spinal osteophytosis in Japanese women
Yoshiji Yamada,Hiroyasu Okuizumi,Akimitsu Miyauchi,Yasuyuki Takagi,Kyoji Ikeda,Atsushi Harada +5 more
TL;DR: The T29-->C polymorphism of the TGFbeta1 gene exhibited inverse patterns of association with genetic susceptibility to spinal osteophytosis and with osteoporosis, although radiographic evaluation of osteophytes might not reflect the actual disease severity.
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Inverse relation between osteoporosis and spondylosis in postmenopausal women as evaluated by bone mineral density and semiquantitative scoring of spinal degeneration.
TL;DR: On the basis of the finding that spondylotic changes in postmenopausal women exhibit positive correlations not only with the lumbar bone mineral density, but also with the remote-site bone mineraldensity, this study supports the view that osteoporosis has an inverse relation with spondYLosis.