Open AccessJournal Article
Relationship between radiographic features and bone mineral density in elderly men.
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TLDR
The radiographic features of lumbar disc degeneration, anterior osteophytes, and end plate sclerosis were associated with an increase in BMD at the spine, and there was a strong negative correlation in terms of age at the femoral neck, though not at the backbone.Abstract:
Lumbar disc degeneration is characterised radiologically by the presence of osteophytes, endplate sclerosis, and disc space narrowing. Our study was designed to assess anterior lumbar osteophytes, disc space narrowing, end plate sclerosis, and bone mineral density (BMD) in the lumbar vertebrae and femoral neck of elderly men. A total of 1000 men, aged between 71 and 90 years, were invited to participate in the study. BMD was assessed at the spine and femoral neck using dual energy X-ray absorptiometry (DXA). We examined the relationship with the degree of lumbar spinal and femoral neck deformity by using the Z-score. Lateral and anterioposterior spinal radiographs were evaluated for features of lumbar disc degeneration. The observers consisted of a consultant physical therapist, a radiologist, and anatomists who together studied the series of radiographs. Anterior lumbar osteophytes (grade 0-3), end-plate sclerosis, and disc space narrowing (grade 0-2) were evaluated. The Pearson correlation test was used to determine the association between radiographic features, the lumbar mineral density (LBMD), and femoral neck mineral density (FNBMD). In all, 90.6% of lumbar vertebral levels showed evidence of anterior osteophytes, 87.5% showed evidence of end plate sclerosis, and 68.2% of disc space narrowing. Additionally, there was a strong negative correlation in terms of age at the femoral neck, though not at the spine. On the other hand, there was a significant correlation between osteophyte grade and end plate sclerosis at the spine. In our study, the radiographic features of lumbar disc degeneration, anterior osteophytes, and end plate sclerosis were associated with an increase in BMD at the spine.read more
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Journal ArticleDOI
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TL;DR: Specific vitamin D receptor alleles were associated with intervertebral disc degeneration as measured by T2‐weighted signal intensity, demonstrating for the first time the existence of genetic susceptibility to this progressive, age‐related degenerative process.
Journal ArticleDOI
The impact of osteophytic and vascular calcifications on vertebral mineral density measurements in men.
TL;DR: Osteophytic calcification exerted an important influence on the measurement of spinal bone density in men, and this effect should be considered in both clinical and research applications of integral vertebral density measures.
Journal ArticleDOI
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TL;DR: This study led to the identification of a novel common genetic risk factor for LDD, confirming that genetic risk factors likely play a significant role in LDD.
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Effect of osteoarthritis in the lumbar spine and hip on bone mineral density and diagnosis of osteoporosis in elderly men and women
TL;DR: Lumbar spine ostoephytes affect most subjects over the age of 60 years, and contribute substantially to lumbar spinal BMD measured in the anteroposterior position by DXA, which is largely direct by virtue of osteophytes being included in the BMD measurement.