Journal ArticleDOI
Release mechanisms in gelforming sustained release preparations
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TLDR
In this paper, a system consisting of quinidine sulfate, excipient and gum (in various concentrations) was tested in tablet form and the release mechanism was established as being limited by the rate of water penetration and back diffusion of the dissolved substance.About:
This article is published in International Journal of Pharmaceutics.The article was published on 1979-06-01. It has received 246 citations till now. The article focuses on the topics: Excipient & Quinidine Sulfate.read more
Citations
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Mechanisms of solute release from porous hydrophilic polymers
TL;DR: In this article, the role of dynamic swelling and the dissolution of the polymer matrix on the release mechanism was discussed, as well as the effect of the tracer/excipient ratio on the poly(vinyl alcohol) release profile.
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Natural Gums and Modified Natural Gums as Sustained-Release Carriers
TL;DR: In this review, recent developments in the area of natural gums and their derivatives as carriers in the sustained release of drugs are explored.
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Mechanisms of Potassium Chloride Release from Compressed, Hydrophilic, Polymeric Matrices: Effect of Entrapped Air
TL;DR: The release of potassium chloride from hydroxypropyl methylcellulose matrices was investigated for tablets prepared with several different compression forces and it was determined that the release kinetics for these systems deviates significantly from the classical t1/2 dependence.
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Gastroretentive drug delivery system of ranitidine hydrochloride: Formulation and in vitro evaluation
TL;DR: The results of the full factorial design indicated that a low amount of citric acid and a high amount of stearic acid favors sustained release of ranitidine hydrochloride from a gastroretentive formulation, indicating that the proper balance between a release rate enhancer and aRelease rate retardant can produce a drug dissolution profile similar to a theoretical dissolution profile.
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pH-independent release of a weakly basic drug from water-insoluble and -soluble matrix tablets
TL;DR: The release of verapamil hydrochloride from tablets composed of ethylcellulose or HPMC and organic acids was found to be pH-independent, and the micro-environmental conditions for the dissolution and diffusion of the weakly basic drug were almost kept constant.
References
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Journal ArticleDOI
Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.
Journal ArticleDOI
Statistical Analysis in Chemistry and the Chemical Industry
TL;DR: Bennett and Franklin this article conducted a statistical analysis in chemistry and the chemical industry and found that statistical analysis of chemistry and chemical industry can be classified into two categories: quantitative analysis and qualitative analysis.
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Influence of shape factors on kinetics of drug release from matrix tablets. I. Theoretical.
TL;DR: An expression having a basic cubic form was derived to describe the in vitro release of drugs from slow-release tablets formulated with a homogeneous insoluble matrix and it was shown that the rate constants may be described in terms of the physicochemical properties of the tablet constituents and the degree of compression.
Related Papers (5)
Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
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