Journal ArticleDOI
Remarkable Amplification of the Self‐Disproportionation of Enantiomers on Achiral‐Phase Chromatography Columns
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This article is published in Angewandte Chemie.The article was published on 2006-01-23. It has received 197 citations till now. The article focuses on the topics: Disproportionation.read more
Citations
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Fluorine in pharmaceutical industry: fluorine-containing drugs introduced to the market in the last decade (2001-2011).
Jiang Wang,María Sánchez-Roselló,José Luis Aceña,Carlos del Pozo,Alexander E. Sorochinsky,Alexander E. Sorochinsky,Alexander E. Sorochinsky,Santos Fustero,Vadim A. Soloshonok,Vadim A. Soloshonok,Hong Liu +10 more
TL;DR: Introduced to the Market in the Last Decade (2001−2011) Jiang Wang,† María Sańchez-Rosello,́‡,§ Jose ́ Luis Aceña, Carlos del Pozo,‡ and Hong Liu.
Journal ArticleDOI
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
Yu Zhou,Jiang Wang,Zhanni Gu,Shuni Wang,Wei Zhu,José Luis Aceña,Vadim A. Soloshonok,Kunisuke Izawa,Hong Liu +8 more
TL;DR: Compounds Currently in Phase II−III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas is presented.
Journal ArticleDOI
Synthetic Methods for Compounds Having CF3–S Units on Carbon by Trifluoromethylation, Trifluoromethylthiolation, Triflylation, and Related Reactions
Journal ArticleDOI
Recent advances in the trifluoromethylation methodology and new CF3-containing drugs
Wei Zhu,Jiang Wang,Shuni Wang,Zhanni Gu,José Luis Aceña,Kunisuke Izawa,Hong Liu,Vadim A. Soloshonok,Vadim A. Soloshonok +8 more
TL;DR: A brief assessment of the methodological field of trifluoromethylation and its possible impact on the development of new CF 3 -containing pharmaceuticals is provided in this paper.
Journal ArticleDOI
Construction of Axial Chirality by Rhodium‐Catalyzed Asymmetric Dehydrogenative Heck Coupling of Biaryl Compounds with Alkenes
Jun Zheng,Shu-Li You +1 more
TL;DR: Novel axially chiral biaryls were synthesized by the direct C-H bond olefination of biaryl compounds, using a chiral [Cp*Rh(III)] catalyst, in good to excellent yields and enantioselectivities.
References
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Journal ArticleDOI
Nonlinear effects in asymmetric synthesis. Examples in asymmetric oxidations and aldolization reactions.
TL;DR: L'oxydation asymetrique du methyl p-tolyl sulfure ou l'epoxydative du geraniol en presence of divers complexes chiraux du titane, ainsi que la reaction Hajos-Parrish catalysee par the proline, sont etudiees en detail.
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Quantitative Analysis of the Chiral Amplification in the Amino Alcohol-Promoted Asymmetric Alkylation of Aldehydes with Dialkylzincs
TL;DR: In this paper, the authors investigated the nonlinear properties of the asymmetric reaction of dimethylzinc and benzaldehyde in the presence of (2S)-3-exo-(dimethylamino)isoborneol [(2S]-DAIB] and showed that the enantiomeric purity of the product is much higher than that of the chiral source, DAIB, while the rate of enantioselective catalysis decreases considerably.
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Synthesis, Absolute Configuration, and Enantiomeric Enrichment of a Cruciferous Oxindole Phytoalexin, (S)-(−)-Spirobrassinin, and Its Oxazoline Analog
Mojmír Suchý,P. Kutschy,Kenji Monde,Hitoshi Goto,Nobuyuki Harada,Mitsuo Takasugi,Milan Dzurilla,Eva Balentova +7 more
TL;DR: No significant dependence of antifungal activity against the fungus Bipolaris leersiae was revealed and absolute configuration of the stereogenic center in natural (S)-(-)-4 was derived from the exciton, calculated via CD methods, and unequivocally confirmed by X-ray crystallographic analyses.
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Unexpected pehnomenon in the high-performance liquid chromatographic anlaysis of racemic 14C-labelled nicotine: Separation of enantiomers in a totally achiral system
K.C. Cundy,Peter A. Crooks +1 more
TL;DR: Experiments were performed which demonstrate that the two 14 C peaks observed are due to the separated enantiomers of the radiolabelled material, which provides a facile method for the isolation of the pure enantiomes of 14 C-labelled nicotine, on a totally achiral system.