Journal ArticleDOI
Remission of metastatic lesions following cryosurgery in prostatic cancer: immunologic considerations.
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This article is published in The Journal of Urology.The article was published on 1970-07-01. It has received 183 citations till now. The article focuses on the topics: Cryosurgery & Cancer.read more
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Thermal ablation of tumours: biological mechanisms and advances in therapy.
Katrina F. Chu,Damian E. Dupuy +1 more
TL;DR: The mechanisms of tumour cell death that are induced by the most common thermoablative techniques are examined and the rapidly developing areas of research in the field are discussed, including combinatorial ablation and immunotherapy, synergy with conventional chemotherapy and radiation, and the development of a new ablation modality in irreversible electroporation.
Journal ArticleDOI
In Situ Tumor Ablation Creates an Antigen Source for the Generation of Antitumor Immunity
Martijn H. den Brok,Roger P.M. Sutmuller,Robbert van der Voort,Erik Bennink,Carl G. Figdor,Theo J.M. Ruers,Gosse J. Adema +6 more
TL;DR: It is demonstrated that following RFA, a weak but detectable immune response develops, directed against OVA, but also against a broader range of B16 antigens, and this strongly enhanced antitumor immunity, resulting in long-lasting tumor protection.
Journal ArticleDOI
Cryo-immunology: a review of the literature and proposed mechanisms for stimulatory versus suppressive immune responses.
TL;DR: The existing evidence regarding tumor cryo-immunology is reviewed and hypotheses regarding patient, tumor and technical factors that may influence the resultant immune response and warrant further investigation are put forward.
Journal ArticleDOI
Potent Induction of Tumor Immunity by Combining Tumor Cryoablation with Anti–CTLA-4 Therapy
Rebecca Waitz,Stephen B. Solomon,Elena N. Petre,Anne E. Trumble,Marcella Fasso,Larry Norton,James P. Allison +6 more
TL;DR: Although cryoablation is currently used to treat a targeted tumor nodule, the results suggest that combination therapy with CTLA-4 blockade will augment antitumor immunity and rejection of tumor metastases in this setting.
Journal ArticleDOI
Experimental cryosurgery investigations in vivo.
TL;DR: In vivo experiments with major organs, including wound healing, the putative immunological response following thawing, and the use of cryoadjunctive strategies to enhance cancer cell sensitivity to freezing, are described.
References
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Journal ArticleDOI
Microtechnical Demonstration of Phosphatase in Tissue Sections.
TL;DR: Preliminary experiments have shown that phosphatase is not destroyed either by alcohol or by exposure to 56°C in completely dehydrated state, and a useable technic has been worked out on the basis of this principle.
Journal Article
Studies in cryo-immunology. I. The production of antibodies to urogenital tissue in consequence of freezing treatment.
TL;DR: Alarge number of rabbits subjected todestructive freezing exhibited the development of arapid antibody response, achieving amaximum antibody response in7-10 days, followed by a decline.
Journal ArticleDOI
Carcinoma of the prostate.
TL;DR: In this paper, the results of palliative treatment of prostatic carcinoma were observed in 1,249 patients followed for five years or more, and 30 out of 100 patients without elevated acid phosphatase levels in the blood or evidence of bone involvement.