Journal ArticleDOI
Renal denervation suppresses ventricular arrhythmias during acute ventricular ischemia in pigs
Dominik Linz,Klaus Wirth,Christian Ukena,Felix Mahfoud,Janine Pöss,Benedikt Linz,Michael Böhm,Hans-Ruprecht Neuberger +7 more
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TLDR
RDN reduced the occurrence of ventricular arrhythmias/fibrillation and attenuated the rise in LVEDP during left ventricular ischemia without affecting infarct size, changes in ventricular contractility, blood pressure, and reperfusion arrh rhythmias.About:
This article is published in Heart Rhythm.The article was published on 2013-10-01. It has received 207 citations till now. The article focuses on the topics: Ventricular pressure & Ventricular fibrillation.read more
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Patent
Renal neuromodulation methods and devices for treatment of polycystic kidney disease
TL;DR: In this paper, the authors proposed a method for treating polycystic kidney disease with therapeutic renal neuromodulation and associated systems and methods, which is directed to methods that at least partially inhibit sympathetic neural activity in nerves proximate a renal artery.
Patent
Catheters with enhanced flexibility and associated devices, systems, and methods
TL;DR: In this article, a neuromodulation catheter is configured to at least partially resist deformation in response to longitudinal compression and tension on the shaft and torsion of the shaft in both first and second opposite circumferential directions.
Journal ArticleDOI
Neuromodulation for the Treatment of Heart Rhythm Disorders
TL;DR: Modulation of autonomic nervous signaling holds significant promise for the prevention and treatment of cardiac arrhythmias and further clinical investigation is necessary to establish the efficacy and safety of autonomics modulatory therapies in reducing cardiac arrHythmias.
Journal ArticleDOI
Atrial Remodeling Following Catheter-Based Renal Denervation Occurs in a Blood Pressure– and Heart Rate–Independent Manner
Stephan H. Schirmer,Marwa M.Y.A. Sayed,Jan-Christian Reil,Daniel Lavall,Christian Ukena,Dominik Linz,Felix Mahfoud,Michael Böhm +7 more
TL;DR: There is a direct, partly BP-independent effect of RDN on cardiac remodeling and occurrence of premature atrial contractions in patients with resistant hypertension 6 months after RDN.
Patent
Neuromodulation and associated systems and methods for the management of pain
TL;DR: In this article, the authors present methods for treating and managing pain in a patient with therapeutic neuromodulation and associated systems and methods are disclosed, which are directed to methods that at least partially inhibit sympathetic neural activity in nerves proximate a target blood vessel of a diseased or damaged organ.
References
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Journal ArticleDOI
ATP-regulated K + channels in cardiac muscle
TL;DR: Application of the patch-clamp technique to CN-treated mammalian heart cells reveals specific K+ channels which are depressed by intracellular ATP (ATPi) at levels greater than 1 mM, which seems to be important for regulation of cellular energy metabolism in the control of membrane excitability.
Journal ArticleDOI
Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): A randomised controlled trial
Murray D. Esler,Henry Krum,Paul A. Sobotka,Markus P. Schlaich,Roland E. Schmieder,Michael Böhm,Felix Mahfoud,Horst Sievert,Nina Wunderlich,Lars Christian Rump,Oliver Vonend,Michael Uder,Mel Lobo,Mark J. Caulfield,Andrejs Erglis,Michel Azizi,Marc Sapoval,S. Thambar,Alexandre Persu,Jean Renkin,Heribert Schunkert,Joachim Weil,Uta C. Hoppe,Tony Walton,Dierk Scheinert,Thomas Binder,Andrzej Januszewicz,Adam Witkowski,Luis M. Ruilope,Robert Whitbourn,Heike Bruck,Mark Downes,Thomas F. Lüscher,Alan G. Jardine,Mark Webster,Thomas Zeller,Jerzy Sadowski,Krzysztof Bartus,Craig A. Straley,Neil C. Barman,David P. Lee,Ronald M. Witteles,Vivek Bhalla,Joseph M. Massaro +43 more
TL;DR: Catheter-based renal denervation can safely be used to substantially reduce blood pressure in treatment-resistant hypertensive patients and should be continued, according to the authors.
Journal ArticleDOI
Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study
Henry Krum,Markus P. Schlaich,Robert Whitbourn,Paul A. Sobotka,Jerzy Sadowski,Krzysztof Bartus,Bogusław Kapelak,Anthony Walton,Horst Sievert,S. Thambar,William T. Abraham,Murray D. Esler +11 more
TL;DR: In this article, a proof-of-principle trial of therapeutic renal sympathetic denervation in patients with resistant hypertension (i.e., systolic blood pressure ≥160 mm/hg on three or more antihypertensive medications, including a diuretic) was conducted to assess safety and blood-pressure reduction effectiveness.
Journal Article
Response to Letter to the Editor: Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of principle cohort study
TL;DR: Catheter-based renal denervation causes substantial and sustained blood-pressure reduction, without serious adverse events, in patients with resistant hypertension, in a proof-of-principle trial of therapeutic renal sympathetic denervation.
Journal ArticleDOI
The Lambeth Conventions: guidelines for the study of arrhythmias in ischaemia, infarction, and reperfusion
Michael J A Walker,Michael J. Curtis,D.J. Hearse,R W Campbell,Michiel J. Janse,Derek M. Yellon,S M Cobbe,S J Coker,J B Harness,D W Harron +9 more
TL;DR: The Lambeth Conventions are guidelines intended to be of practical value in the investigation of arrhythmias induced by ischaemia, infarction, and reperfusion and are encouraged to adopt in the hope that this will improve uniformity and interlaboratory comparisons.
Related Papers (5)
Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): A randomised controlled trial
Murray D. Esler,Henry Krum,Paul A. Sobotka,Markus P. Schlaich,Roland E. Schmieder,Michael Böhm,Felix Mahfoud,Horst Sievert,Nina Wunderlich,Lars Christian Rump,Oliver Vonend,Michael Uder,Mel Lobo,Mark J. Caulfield,Andrejs Erglis,Michel Azizi,Marc Sapoval,S. Thambar,Alexandre Persu,Jean Renkin,Heribert Schunkert,Joachim Weil,Uta C. Hoppe,Tony Walton,Dierk Scheinert,Thomas Binder,Andrzej Januszewicz,Adam Witkowski,Luis M. Ruilope,Robert Whitbourn,Heike Bruck,Mark Downes,Thomas F. Lüscher,Alan G. Jardine,Mark Webster,Thomas Zeller,Jerzy Sadowski,Krzysztof Bartus,Craig A. Straley,Neil C. Barman,David P. Lee,Ronald M. Witteles,Vivek Bhalla,Joseph M. Massaro +43 more