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Reply to "Comment on: Pathological features of 11,337 patients with primary ductal carcinoma in situ (DCIS) and subsequent events: results from the UK Sloane Project".
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This article is published in British Journal of Cancer.The article was published on 2021-02-16. It has received 1 citations till now. The article focuses on the topics: Ductal carcinoma in situ (DCIS).read more
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The presentation, management and outcome of patients with ductal carcinoma in situ (DCIS) with microinvasion (invasion ≤1 mm in size)—results from the UK Sloane Project
Abeer M Shaaban,Bridget Hilton,Karen Clements,David Dodwell,Nisha Sharma,Cliona C. Kirwan,Elinor J. Sawyer,Anthony J. Maxwell,Matthew G. Wallis,Hilary Stobart,Senthurun Mylvaganam,J.C. Litherland,Samantha Brace-McDonnell,Joanna Dulson-Cox,Olive Kearins,Elena Provenzano,Ian O. Ellis,Sarah E Pinder,Alastair M. Thompson +18 more
TL;DR: In this paper , the outcomes of patients with DCIS with and without micro-invasion diagnosed between 2003 and 2012 within the Sloane project were analyzed, with a considerable variation in reported incidence among screening units (0-25%), with microinvasion associated with high grade DCIS, larger DCIS size, comedo necrosis and solid, cribriform architecture.
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The natural history of low-grade ductal carcinoma in situ of the breast in women treated by biopsy only revealed over 30 years of long-term follow-up.
TL;DR: The biopsies in the current study were originally examined, small DCIS was not diagnosed and, by default, these women were treated by biopsy only, so the proclivity for local recurrence in the original site was underestimated.
Journal ArticleDOI
Pathological features of 11,337 patients with primary ductal carcinoma in situ (DCIS) and subsequent events: results from the UK Sloane Project
Abeer M Shaaban,Bridget Hilton,Karen Clements,Elena Provenzano,S. Cheung,Matthew G. Wallis,Elinor J. Sawyer,Jeremy Thomas,Andrew M. Hanby,Sarah E Pinder,Alastair M. Thompson +10 more
TL;DR: Ipsilateral DCIS events lessened after 5 years, while the risk of ipsilateral invasive cancer remained consistent to beyond 10 years, highlighting the need for prolonged follow-up of screen-detected DCIS.
Journal ArticleDOI
Estrogen-receptor status and risk of contralateral breast cancer following DCIS.
Natasha K. Stout,Angel M. Cronin,Hajime Uno,Elissa M. Ozanne,Michael J. Hassett,Elizabeth S. Frank,Caprice C. Greenberg,Rinaa S. Punglia +7 more
TL;DR: This finding suggests that ER+ DCIS may represent a field effect that confers increased propensity for developing cancer across breast tissue, regardless of laterality.
Proceedings ArticleDOI
Abstract P4-07-04: Genomic analysis of paired DCIS and subsequent recurrence to assess clonal relatedness in screen detected DCIS
Vandna Shah,Anargyros Megalios,Rana Shami,Mathini Sridharan,Carolina Salinas de Souza,Tapsi Kumar,Karen Clements,Andrew Futreal,Sarah E Pinder,Alastair M. Thompson,Elinor J. Sawyer +10 more
TL;DR: This study shows synchronous DCIS and IDC are clonally related as is DCIS that recurs as DCIS in the majority of cases, but it remains to be seen whether exome sequencing of the unrelated lesions would reveal evidence of relatedness or whether they are truly new primaries.
Journal ArticleDOI
Comment on: “Pathological features of 11,337 patients with primary ductal carcinoma in situ (DCIS) and subsequent events: results from the UK Sloane Project”
Mieke R. Van Bockstal,Mieke R. Van Bockstal,Louis Libbrecht,Louis Libbrecht,Louis Libbrecht,Christine Galant,Christine Galant +6 more