BookDOI
Resistance to Immunotoxins in Cancer Therapy
TLDR
This volume is a guide to understanding resistance against targeted therapeutic approaches for cancer using immunotoxins and includes an in-depth description of the molecular and cellular mechanisms involved in cancer resistance and several novel methods to overcome resistance.Abstract:
This volume is a guide to understanding resistance against targeted therapeutic approaches for cancer using immunotoxins. It contains a detailed review of the history and development of targeted therapy. As well, it includes an in-depth description of the molecular and cellular mechanisms involved in cancer resistance and several novel methods to overcome resistance. Each chapter discusses different aspects of resistance and covers all the factors that may contribute to resistance in cancer cells. Finally, this volume highlights the recent findings and advances associated with tackling cancer resistanceread more
Citations
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Site-specific mutagenesis reveals differences in the structural bases for tight binding of RNase inhibitor to angiogenin and RNase A
TL;DR: The structural basis for the recognition of two RI ligands, human angiogenin (Ang) and bovine RNase A, has been investigated by site-specific mutagenesis of human RI and Ang.
Journal ArticleDOI
Transcriptional drug repositioning and cheminformatics approach for differentiation therapy of leukaemia cells.
Yasaman KalantarMotamedi,Fatemeh Ejeian,Faezeh Sabouhi,Faezeh Sabouhi,Leila Bahmani,Alireza Shoaraye Nejati,Aditya M. Bhagwat,Ali Mohammad Ahadi,Ali Mohammad Ahadi,Azita Parvaneh Tafreshi,Mohammad Hossein Nasr-Esfahani,Andreas Bender +11 more
TL;DR: In this paper, a novel transcriptional drug repositioning approach based on both bioinformatics and cheminformatics components was proposed to identify small molecules for differentiation therapy in cancer.
References
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Journal ArticleDOI
Reshaping human antibodies for therapy.
TL;DR: A human IgGI antibody has been reshaped for serotherapy in humans by introducing the six hypervariable regions from the heavy- and light-chain variable domains of a rat antibody directed against human lymphocytes.
Journal ArticleDOI
Fc RECEPTOR BIOLOGY
TL;DR: In this paper, a review of membrane Fc receptors (FcR) of the immunoglobulin superfamily is presented, focusing on the mechanisms by which FcR trigger and regulate biological responses of cells on which they are expressed.
Journal ArticleDOI
Isolation and characterization of angiogenin, an angiogenic protein from human carcinoma cells
James W. Fett,Daniel J. Strydom,Roy R. Lobb,Edward M. Alderman,J. Lemuel Bethune,James F. Riordan,Bert L. Vallee +6 more
TL;DR: The first human tumor derived protein with in vivo angiogenic activity to be obtained in pure form has been isolated from serum-free supernatants of an established human adenocarcinoma cell line (HT-29) and named angiogenin.
Journal ArticleDOI
Efficacy and Safety of Gemtuzumab Ozogamicin in Patients With CD33-Positive Acute Myeloid Leukemia in First Relapse
Eric L. Sievers,Richard A. Larson,Edward A. Stadtmauer,Elihu H. Estey,Bob Löwenberg,Hervé Dombret,Chatchada Karanes,Matthias Theobald,John M. Bennett,Matthew L. Sherman,Mark S. Berger,Catharine B. Eten,Michael R. Loken,Jacques J. M. Van Dongen,Irwin D. Bernstein,Frederick R. Appelbaum +15 more
TL;DR: Administration of the antibody-targeted chemotherapy agent Mylotarg to patients with CD33-positive acute myeloid leukemia in first relapse induces complete remissions with what appears to be a favorable safety profile.
Journal ArticleDOI
A simple physical model for binding energy hot spots in protein-protein complexes.
Tanja Kortemme,David Baker +1 more
TL;DR: The results test the understanding of the dominant contributions to the free energy of protein–protein interactions, can guide experiments aimed at the design of protein interaction inhibitors, and provide a stepping-stone to important applications such as interface redesign.