D
Davorka Messmer
Researcher at University of California, San Diego
Publications - 56
Citations - 3876
Davorka Messmer is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Chronic lymphocytic leukemia & CD40. The author has an hindex of 27, co-authored 56 publications receiving 3634 citations. Previous affiliations of Davorka Messmer include North Shore-LIJ Health System & New York University.
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Journal ArticleDOI
In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells.
Bradley T. Messmer,Davorka Messmer,Steven L. Allen,Steven L. Allen,Jonathan E. Kolitz,Jonathan E. Kolitz,Prasad Kudalkar,Prasad Kudalkar,Denise Cesar,Elizabeth Murphy,Prasad Koduru,Prasad Koduru,Manlio Ferrarini,Simona Zupo,Giovanna Cutrona,Rajendra N. Damle,Rajendra N. Damle,Tarun Wasil,Tarun Wasil,Kanti R. Rai,Kanti R. Rai,Marc K. Hellerstein,Marc K. Hellerstein,Nicholas Chiorazzi,Nicholas Chiorazzi +24 more
TL;DR: B-CLL is not a static disease that results simply from accumulation of long-lived lymphocytes, Rather, it is a dynamic process composed also of cells that proliferate and die, often at appreciable levels, the extent to which this turnover occurs has not been previously appreciated.
Journal ArticleDOI
Multiple Distinct Sets of Stereotyped Antigen Receptors Indicate a Role for Antigen in Promoting Chronic Lymphocytic Leukemia
Bradley T. Messmer,Emilia Albesiano,Dimitar G. Efremov,Fabio Ghiotto,Fabio Ghiotto,Steven L. Allen,Jonathan E. Kolitz,Robin Foà,Rajendra N. Damle,Franco Fais,Davorka Messmer,Kanti R. Rai,Kanti R. Rai,Manlio Ferrarini,Nicholas Chiorazzi +14 more
TL;DR: Five sets of patients with strikingly similar B cell antigen receptors arising from the use of common H and L chain V region gene segments are described, implying a much more striking degree of structural restriction of the entire BCR and a much higher frequency of receptor sharing among patients than appreciated previously.
Journal ArticleDOI
High Mobility Group Box Protein 1: An Endogenous Signal for Dendritic Cell Maturation and Th1 Polarization
Davorka Messmer,Huan Yang,Huan Yang,Gloria Telusma,Faye Knoll,Jianhua Li,Jianhua Li,Bradley T. Messmer,Kevin J. Tracey,Kevin J. Tracey,Nicholas Chiorazzi +10 more
TL;DR: It is shown that HMGB1, via its B box domain, induced phenotypic maturation of DCs, as evidenced by increased CD83, CD54, CD80, CD40, CD58, and MHC class II expression and decreased CD206 expression.
Journal ArticleDOI
High-mobility group box 1 (HMGB1) protein: Friend and foe
Luis Ulloa,Davorka Messmer +1 more
TL;DR: The immuno-regulatory role of HMGB1 and its contribution to infectious and inflammatory disorders are focused on.
Journal ArticleDOI
ISO-1 Binding to the Tautomerase Active Site of MIF Inhibits Its Pro-inflammatory Activity and Increases Survival in Severe Sepsis
Yousef Al-Abed,Darrin Dabideen,Bayan Aljabari,Aline Valster,Davorka Messmer,Mahendar Ochani,Mahira Tanovic,Kanta Ochani,Michael Bacher,Ferdinando Nicoletti,Christine N. Metz,Valentin A. Pavlov,Edmund J Miller,Kevin J. Tracey +13 more
TL;DR: The results identify ISO-1 as the first small molecule inhibitor of MIF proinflammatory activities with therapeutic implications and indicate the potential of the MIF active site as a novel target for therapeutic interventions in human sepsis.