Journal ArticleDOI
Resistance to Schistosoma mansoni in Humans: Influence of the IgE/IgG4 Balance and IgG2 in Immunity to Reinfection after Chemotherapy
TLDR
The hypothesis of an association between human resistance to reinfection by the parasite Schistosoma mansoni and anti-larval immunoglobulin isotypes was tested by logistic regression in the presence of the explicative variables water contact, age, and sex as discussed by the authors.Abstract:
The hypothesis of an association between human resistance to reinfection by the parasite Schistosoma mansoni and anti-larval immunoglobulin isotypes was tested by logistic regression in the presence of the explicative variables water contact, age, and sex. Of the seven isotypes tested (IgM, IgG1, IgG2, IgG3, IgG4, IgA, and IgE), only IgE, IgG4, and IgG2 showed an association (positive for IgE and negative for IgG2 and IgG4) with resistance to reinfection after chemotherapy. The opposite effects of IgE and IgG4 were undissociable in the analysis, indicating that these isotypes probably antagonize each other in protection. The negative association of IgG2 with resistance is consistent with the view that anti-carbohydrate antibodies may facilitate reinfection. Finally, epidemiologic and immunologic studies support the view that there is a progressive but slow development of acquired immunity in children and adolescents.read more
Citations
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Journal ArticleDOI
The immunobiology of schistosomiasis
TL;DR: Advances in the understanding of the immunology of schistosomiasis are summarized, with the bulk of the review reflecting the experimental focus on Schistosoma mansoni infection in mice.
Journal ArticleDOI
Genetic localization of a locus controlling the intensity of infection by Schistosoma mansoni on chromosome 5q31-q33
Sandrine Marquet,Laurent Abel,Dominique Hillaire,Hélia Dessein,Jorge Kalil,Josué Feingold,Jean Weissenbach,Alain Dessein +7 more
TL;DR: To localize this gene, referred to as SM1, a genome-wide study on 142 Brazilian subjects belonging to 11 informative families showed a linkage to only one region, on chromosome 5q31–q33, with maximum two-point lod scores, indicating a close proximity to CSF1R as the most likely location of SM1.
Journal ArticleDOI
Schistosomiasis in the People's Republic of China: Prospects and Challenges for the 21st Century
Allen G. Ross,Adrian Sleigh,Yuesheng Li,George M. Davis,Gail M. Williams,Zheng Jiang,Zheng Feng,Donald P. McManus +7 more
TL;DR: An overview of the biology, epidemiology, clinical features, and prospects for control of oriental schistosomiasis in the People's Republic of China is provided.
Journal ArticleDOI
Immunology of human schistosomiasis.
TL;DR: There is a wealth of immunologic studies that have been carried out in experimental and human schistosomiasis that can be classified into three main areas: immunopathogenesis, resistance to reinfection and diagnostics, which contribute to the public health response to humanSchistosome infections.
Journal ArticleDOI
Suppression of TH2-type allergic reactions by helminth infection.
TL;DR: Harnessing current mechanistic studies for translational research into helminth infections and atopy might have potential for the identification of novel biomarkers, and even therapeutics, in allergic diseases.
References
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Book
Applied Logistic Regression
David W. Hosmer,Stanley Lemeshow +1 more
TL;DR: Hosmer and Lemeshow as discussed by the authors provide an accessible introduction to the logistic regression model while incorporating advances of the last decade, including a variety of software packages for the analysis of data sets.
Book
Principles and Practice of Infectious Diseases
TL;DR: This updated and expanded edition now offers 297 chapters that cover the basic principles of diagnosis and management, major clinical syndromes, all important pathogenic microbes and the diseases they cause, plus a number of specialised topics useful to the practitioner.
Journal ArticleDOI
Human IgE, IgG4 and resistance to reinfection with Schistosoma haematobium
TL;DR: The results support the hypothesis that the slow build-up of IgE to high levels and the early production of IgG4 antibodies, which may block IgE pathways, are responsible for delaying the development of protective immunity to S. haematobium.
Journal ArticleDOI
Studies on human antibodies : vi. selective variations in subgroup composition and genetic markers
TL;DR: The composition of various isolated antibodies was determined by quantitative analyses for heavy chain subgroups and light chain types, and one anti-levan antibody studied was uniquely homogeneous, consisting exclusively of γG2-heavy chains and kappa light chains.