Journal ArticleDOI
Response to: "Some considerations about γδ and CD8+ T-cell responses in blood after gluten challenge in treated celiac disease".
Louise Fremgaard Risnes,Linn M Eggesbø,Asbjørn Christophersen,Ludvig M. Sollid,Ludvig M. Sollid +4 more
About:
This article is published in Mucosal Immunology.The article was published on 2021-06-09. It has received 4 citations till now. The article focuses on the topics: Gluten & Cytotoxic T cell.read more
Citations
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Journal ArticleDOI
Single-cell approaches to dissect adaptive immune responses involved in autoimmunity: the case of celiac disease.
TL;DR: A review of single-cell studies providing information on adaptive immune cells and outline some future perspectives in the area of singlecell analysis in autoimmune diseases can be found in this article, where the authors discuss the use of single cell analysis in the diagnosis of celiac disease.
Journal ArticleDOI
Single-cell approaches to dissect adaptive immune responses involved in autoimmunity: the case of celiac disease
TL;DR: A review of single-cell studies providing information on adaptive immune cells and outline some future perspectives in the area of singlecell analysis in autoimmune diseases can be found in this article , where the authors discuss the use of single cell analysis in the diagnosis of celiac disease.
Journal ArticleDOI
Activated gut-homing CD8+ T cells for coeliac disease diagnosis on a gluten-free diet.
F Fernández-Bañares,Natalia López-Palacios,María Corzo,Beatriz Arau,Mercedes Galindo Rubio,Marta Fernández-Prieto,Eva Tristán,Mar Pujals,Sergio Farrais,Saúl Horta,Juana María Hernández,Marta Gomez-Perosanz,Pedro A. Reche,Maria Esteve,Concepción Núñez +14 more
TL;DR: In this paper, the diagnostic accuracy of activated gut-homing CD8+ and TCRγδ+ T cells in blood after a 3-day gluten challenge and to compare it with the performance of IFN-γ ELISPOT in a HLA-DQ2.5 subsample.
Book ChapterDOI
Assessment of activated gut-homing CD8+ T cells in blood by flow cytometry during a 3-day gluten challenge
TL;DR: In this paper , the authors developed an accurate but simple method that requires only a 3-day gluten challenge and circumvents the main limitations of previously suggested proposals such as requirement of specific peptides and unusual specialized lab facilities or high cost.
References
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Journal ArticleDOI
Dietary gluten triggers concomitant activation of CD4+ and CD8+ αβ T cells and γδ T cells in celiac disease
Arnold Han,Evan W. Newell,Jacob Glanville,Nielsen Fernandez-Becker,Chaitan Khosla,Yueh-hsiu Chien,Mark M. Davis +6 more
TL;DR: A previously unappreciated role of antigen is revealed in the induction of CD8+ αβ and γδ T cells in celiac disease and a coordinated response by all three of the major types of T cells is demonstrated.
Journal ArticleDOI
HLA-DQ:gluten tetramer test in blood gives better detection of coeliac patients than biopsy after 14-day gluten challenge
Vikas Kumar Sarna,Gry Irene Skodje,Henrik M. Reims,Louise Fremgaard Risnes,Shiva Dahal-Koirala,Ludvig M. Sollid,Knut E.A. Lundin +6 more
TL;DR: A 14-day gluten challenge was not enough to establish significant mucosal architectural changes in majority of patients with coeliac disease, but an increase in CD4+ effector-memory gut-homing HLA-DQ:gluten tetramer-binding T cells in blood 6 days after gluten challenge is a more sensitive and less invasive biomarker that should be validated in a larger study.
Journal ArticleDOI
Evaluating Responses to Gluten Challenge: A Randomized, Double-Blind, 2-Dose Gluten Challenge Trial.
Maureen M. Leonard,Jocelyn A. Silvester,Jocelyn A. Silvester,Jocelyn A. Silvester,Daniel A. Leffler,Daniel A. Leffler,Alessio Fasano,Ciaran P. Kelly,Ciaran P. Kelly,Suzanne K. Lewis,Jeff Goldsmith,Jeff Goldsmith,Elliot Greenblatt,William W. Kwok,William J. McAuliffe,Kevin Galinsky,Jenifer Siegelman,I-Ting Chow,John A. Wagner,Anna Sapone,Glennda Smithson +20 more
TL;DR: Modern biomarkers are sensitive and responsive to gluten exposure, potentially allowing less invasive, lower-dose, shorter-duration gluten ingestion and providing a preliminary framework for rational design of gluten challenge for CeD research.
Journal ArticleDOI
Evaluation of T cells in blood after a short gluten challenge for coeliac disease diagnosis.
Natalia López-Palacios,Virginia Pascual,Mercedes Castaño,Andrés Bodas,Marta Fernández-Prieto,Laura Espino-Paisán,Eva Martínez-Ojinaga,Isabel Salazar,Raquel Martínez-Curiel,Enrique Rey,Lourdes Estrada,Magdalena Molero-Abraham,Pedro A. Reche,Romina Dieli-Crimi,Concepción Núñez +14 more
TL;DR: A short three-day gluten challenge elicits the activation of CD103+ β7hi CD8+ T cells in CD, which can be detected by flow cytometry in peripheral blood, opening new possibilities for CD diagnosis in individuals on a GFD.
Journal ArticleDOI
In Well‐Treated Celiac Patients Low‐Level Mucosal Inflammation Predicts Response to 14‐day Gluten Challenge
Jorunn Stamnaes,Jorunn Stamnaes,Daniel Stray,Daniel Stray,Maria Stensland,Vikas Kumar Sarna,Tuula A. Nyman,Knut E.A. Lundin,Knut E.A. Lundin,Ludvig M. Sollid,Ludvig M. Sollid +10 more
TL;DR: In this paper, proteome analysis of total tissue or isolated epithelial cell compartment from formalin-fixed paraffin embedded biopsies collected before and after 14-day gluten challenge demonstrates that patients with strong mucosal response to challenge have signs of ongoing tissue inflammation already before challenge.