Single-cell approaches to dissect adaptive immune responses involved in autoimmunity: the case of celiac disease.
TLDR
A review of single-cell studies providing information on adaptive immune cells and outline some future perspectives in the area of singlecell analysis in autoimmune diseases can be found in this article, where the authors discuss the use of single cell analysis in the diagnosis of celiac disease.About:
This article is published in Mucosal Immunology.The article was published on 2021-09-16 and is currently open access. It has received 3 citations till now. The article focuses on the topics: Immune system & Autoimmunity.read more
Citations
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Journal ArticleDOI
Immunopathogenesis and environmental triggers in coeliac disease
TL;DR: Demonstration that lymphomas complicating CD arise from IEL that have acquired gain-of-function JAK1 or STAT3 mutations stresses the key role of this pathway and explains how gluten-driven chronic inflammation may promote this rare but most severe complication.
Journal ArticleDOI
A transcriptome atlas and interactive analysis platform for autoimmune disease
Zhuo-zhi Shen,Minghao Fang,Wujianan Sun,Meifang Tang,Nianping Liu,Lin Zhu,Qian Liu,Bin Li,Ruoming Sun,Yu Shi,C.B. Guo,Jun Lin,Kun Qu +12 more
TL;DR: A user-friendly web database tool, Interactive Analysis and Atlas for Autoimmune disease (IAAA), which integrates bulk RNA-seq data of 929 samples of 10 autoimmune diseases and single-cell RNA- sequencing data of 783 203 cells in 96 samples of 6 autoimmune diseases is developed.
Journal ArticleDOI
Characterisation of T cell receptor repertoires in coeliac disease
Lik Wee Lee,Shahin Shafiani,Beryl Crossley,Ryan O. Emerson,David Williamson,Anna Bunin,J Vargas,Arnold Han,Ian Kaplan,Peter H.R. Green,Ilan R. Kirsch,Govind Bhagat +11 more
TL;DR: In this paper , the authors performed next-generation sequencing of complementarity-determining region 3 (CDR3) of rearranged T cell receptor β (TRB) and γ (TRG) genes using DNA extracted from intraepithelial cell (IEC) and lamina propria cell (LPC) fractions and a small subset of peripheral blood mononuclear cell (PBMC) samples obtained from CD and non-CD (control) patients.
References
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Phenotypic Analysis of Antigen-Specific T Lymphocytes
John D. Altman,Paul Moss,Philip J. R. Goulder,Dan H. Barouch,Michael G. McHeyzer-Williams,John I. Bell,Andrew J. McMichael,Mark M. Davis +7 more
TL;DR: Tetramers of human lymphocyte antigen A2 that were complexed with two different human immunodeficiency virus (HIV)-derived peptides or with a peptide derived from influenza A matrix protein bound to peptide-specific cytotoxic T cells in vitro and to T cells from the blood of HIV-infected individuals and correlated well with cytotoxicity assays.
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Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA
Stefan Bauer,Veronika Groh,Jun Wu,Alexander Steinle,Joseph H. Phillips,Lewis L. Lanier,Thomas Spies +6 more
TL;DR: An activating immunoreceptor-MHC ligand interaction that may promote antitumor NK and T cell responses is defined.
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Follicular Helper CD4 T Cells (TFH)
TL;DR: This review discusses recent progress and areas of uncertainty or disagreement in the literature, and debates the developmental relationship between T(FH) cells and other CD4 T cell subsets (Th1, Th2, Th17, iTreg).
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Identification of tissue transglutaminase as the autoantigen of celiac disease
Walburga Dieterich,Tobias Ehnis,Michael Bauer,Peter Donner,Umberto Volta,Ernst Otto Riecken,Detlef Schuppan +6 more
TL;DR: Tissue transglutaminase is identified as the unknown endomysial autoantigen of celiac disease, and gliadin is a preferred substrate for this enzyme, giving rise to novel antigenic epitopes.
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Simultaneous epitope and transcriptome measurement in single cells.
Marlon Stoeckius,Christoph Hafemeister,William Stephenson,Brian Houck-Loomis,Pratip K. Chattopadhyay,Harold Swerdlow,Rahul Satija,Peter Smibert +7 more
TL;DR: In this article, a method called cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq) is proposed, in which oligonucleotide-labeled antibodies are used to integrate cellular protein and transcriptome measurements into an efficient, single-cell readout.