Journal ArticleDOI
Risk Factors for Clostridium difficile Carriage and C. difficile-Associated Diarrhea in a Cohort of Hospitalized Patients
Reads0
Chats0
TLDR
In this paper, a prospective cohort study of 399 consecutive patients in a single ward over an 11-month period was conducted to identify risk factors for nosocomial C. difficile colonization and diarrhea.Abstract:
A prospective cohort study of 399 consecutive patients in a single ward over an 11-month period was conducted to identify risk factors for nosocomial C. difficile colonization and diarrhea. The incidence of asymptomatic carriage was 13.0/100 patient admissions and the incidence of C. difficile-associated diarrhea was 7.8/100 patient admissions. Increased age and more severe underlying illness were associated with increased risk of C. difficile carriage and diarrhea. Multivariate models adjusting for age and severity of underlying disease associated two risk factors with asymptomatic C. difficile carriage: stool softeners (relative risk [RR] = 2.04) and antacids (RR = 1.80). Five risk factors were associated with C. difficile-associated diarrhea: cephalosporin use (RR = 2.07), penicillin use (RR = 3.41), enemas (RR = 3.26), gastrointestinal stimulants (RR = 3.06), and stool softeners (RR = 1.74). C. difficile was a common nosocomial infection on this ward, resulting in asymptomatic carriage more often than diarrhea and accounting for one-fifth of all cases of nosocomial diarrhea.read more
Citations
More filters
Journal ArticleDOI
Clinical Practice Guidelines for Clostridium difficile Infection in Adults: 2010 Update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA)
Stuart H. Cohen,Dale N. Gerding,Stuart Johnson,Ciaran P. Kelly,Vivian G. Loo,L. Clifford McDonald,Jacques Pépin,Mark H. Wilcox +7 more
TL;DR: This guideline updates recommendations regarding epidemiology, diagnosis, treatment, and infection control and environmental management of Clostridium difficile.
Journal ArticleDOI
A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality.
Vivian G. Loo,Louise Poirier,Mark A. Miller,Matthew Oughton,Michael Libman,Sophie Michaud,Anne-Marie Bourgault,Tuyen Nguyen,Charles Frenette,Mirabelle Kelly,Anne Vibien,Paul Brassard,Susan Fenn,Ken Dewar,Thomas J. Hudson,Ruth Horn,Pierre René,Yury Monczak,Andre Dascal +18 more
TL;DR: A strain of C. difficile that was resistant to fluoroquinolones and had binary toxin and a partial deletion of the tcdC gene was responsible for this outbreak ofC.difficile-associated diarrhea.
Journal ArticleDOI
Clostridium difficile Infection
TL;DR: This article reviews the pathogenesis, epidemiology, diagnosis, and treatment of this nosocomial and potentially fatal infectious diarrhea, as well as the associated risk factors.
Journal ArticleDOI
Guidelines for Diagnosis, Treatment, and Prevention of Clostridium difficile Infections
Christina M. Surawicz,Lawrence J. Brandt,David G. Binion,Ashwin N. Ananthakrishnan,Scott R. Curry,Peter H. Gilligan,Lynne V. McFarland,Mark Mellow,Brian S. Zuckerbraun +8 more
TL;DR: Treatment of patients with CDI should be stratified depending on whether they have mild-to-moderate, severe, or complicated disease, and a classification of disease severity is proposed to guide therapy that is useful for clinicians.
References
More filters
Journal Article
Statistical methods in cancer research. Volume II--The design and analysis of cohort studies.
N. E. Breslow,N. E. Day +1 more
TL;DR: What do you do to start reading statistical methods in cancer research vol ii the design and analysis of cohort studies?
Journal ArticleDOI
Nosocomial acquisition of Clostridium difficile infection
TL;DR: Nosocomial C. difficile infection, which was associated with diarrhea in about one third of cases, is frequently transmitted among hospitalized patients and that the organism is often present on the hands of hospital personnel caring for such patients.
Journal ArticleDOI
Clostridium difficile Colitis
TL;DR: Clostridium difficile, the agent that causes pseudomembranous colitis associated with antibiotic therapy, has been identified in recent years as a common nosocomial pathogen.
Journal Article
Epidemiologic Analysis with a Programmable Calculator
Journal ArticleDOI
Binomial regression in glim: estimating risk ratios and risk differences
TL;DR: Macros for use with the program GLIM provide a simple method to compute parameters other than the odds ratio while adjusting for confounding factors.