Journal ArticleDOI
Risk Factors for Disseminated or Fatal Histoplasmosis: Analysis of a Large Urban Outbreak
Lawrence J. Wheat,Thomas G. Slama,James A. Norton,Richard B. Kohler,Hal E. Eitzen,Morris L. V. French,Boonmee Sathapatayavongs +6 more
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TLDR
An outbreak of histoplasmosis in Indianapolis involving 488 clinically recognized cases including 60 patients with disseminated or fatal infection permitted statistical analysis of risk factors.Abstract:
An outbreak of histoplasmosis in Indianapolis involving 488 clinically recognized cases including 60 patients with disseminated or fatal infection permitted statistical analysis of risk factors. Being male, white, under 5 years of age, having chronic obstructive lung disease, and living near the presumed source of the outbreak were not risk factors for fatal or disseminated histoplasmosis. Age greater than 54 years and immunosuppression were the only risk factors for disseminated or fatal infection. Dissemination should be excluded in patients with histoplasmosis who are immunosuppressed or older than 54 years. Specific antifungal treatment is more likely to be required in those two groups rather than in patients without risk factors.read more
Citations
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Journal ArticleDOI
Histoplasmosis in the acquired immune deficiency syndrome
TL;DR: Dseminated histoplasmosis is a major opportunistic infection in patients with AIDS from endemic areas and AIDS should be strongly considered in otherwise healthy persons with disseminated Histoplasma serologic tests, especially if risk factors for AIDS are present.
Journal ArticleDOI
Systemic histoplasmosis: a 15-year retrospective institutional review of 111 patients.
TL;DR: Systemic histoplasmosis should be suspected in patients who have lived in endemic areas with fever, bone marrow suppression, and elevated hepatic enzymes, particularly if they are immunocompromised, and Evaluation including a combination of Histoplasma serologic screening, urine antigen assay, and fungal culture will secure the diagnosis in most cases.
Journal ArticleDOI
Progressive disseminated histoplasmosis in patients with acquired immunodeficiency syndrome
Philip C. Johnson,Philip C. Johnson,Nancy Khardor,Nancy Khardor,Amjad F. Najjar,Amjad F. Najjar,Faheem Butt,Faheem Butt,Peter W. A. Mansell,Peter W. A. Mansell,George A. Sarosi,George A. Sarosi +11 more
TL;DR: Progressive disseminated histoplasmosis is often the first sign of immunodeficiency in patients with AIDS, and the diagnosis of this condition is most often established by bone marrow biopsy and culture.
Journal ArticleDOI
Dimorphism in Histoplasma capsulatum: a model for the study of cell differentiation in pathogenic fungi.
Bruno Maresca,G. S. Kobayashi +1 more
TL;DR: This review describes the work done in the last several years at the biochemical and molecular levels on the mechanisms involved in the mycelium to yeast phase transition and speculates on possible models of regulation of morphogenesis in dimorphic pathogenic fungi.
Journal ArticleDOI
Fungal infections in patients with AIDS and AIDS-related complex.
TL;DR: The most common life-threatening fungal infection experienced by AIDS patients is cryptococcosis, a disease occurring among 6% of American AIDS patients and having a mortality rate of 17% during initial infections and 75-100% on relapse.
References
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Journal ArticleDOI
Disseminated histoplasmosis: clinical and pathologic correlations.
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The Effect of Aging on Susceptibility to Infection
TL;DR: There appears to be a network of factors in the aging body, including degenerative changes and the declining immune response, that interact with and compound each other to markedly increase susceptibility to infection.
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Histoplasmosis in immunosuppressed patients
TL;DR: Infection with Histoplasma capsulatum in 58 patients whose immune responses were suppressed (Immunosuppressed patients) was analyzed, and the response to amphotericin B therapy was excellent in those patients in whom the diagnosis was established early and in whom a full course of antifungal therapy could be given.
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Histoplasmosis in Man: report of seven cases and a review of seventy-one cases.
TL;DR: The purpose of this paper is to report the 5 cases of histoplasmosis which have been observed at the University of Michigan Hospital, 1 case that originated in Ohio but was diagnosed in the Department of Pathology of theUniversity of Michigan, and1 case that was diagnosed by Dr. Paul Steiner of.
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The course and prognosis of histoplasmosis
TL;DR: An analysis of 123 culturally proved cases of histoplasmosis is presented, finding that this infection characteristically progresses gradually over several years, although remissions and exacerbations may occur.