Risk Factors for Steatorrhea in Chronic Pancreatitis: A Cohort of 2,153 Patients
Bai-Rong Li,Jun Pan,Ting-Ting Du,Zhuan Liao,Bo Ye,Wen-Bin Zou,Hui Chen,Jun-Tao Ji,Zhao-Hong Zheng,Dan Wang,Jin-Huan Lin,Shou-Bin Ning,Liang-Hao Hu,Zhao-Shen Li +13 more
TLDR
Analysis of both retrospectively and prospectively acquired database for CP patients admitted to the authors' center from January 2000 to December 2013 concluded that male gender, adult, diabetes, alcohol abuse and pancreaticoduodenectomy lead to increased risk of steatorrhea in CP patients.Abstract:
This study aimed to investigate the occurrence of and determine the risk factors for steatorrhea in chronic pancreatitis (CP). It was based on analysis of both retrospectively and prospectively acquired database for CP patients admitted to our center from January 2000 to December 2013. Demographic data, course of disease, medical history and follow-up evaluations of patients were documented in detail. Cumulative rate of steatorrhea was calculated by using the Kaplan–Meier method. For risk factor analysis, multivariate analysis by Cox proportional hazards regression model was performed. A total of 2,153 CP patients were included with a mean follow-up duration of 9.3 years. Approximately 14% (291/2,153) of CP patients presented with steatorrhea at diagnosis of CP. Cumulative rates of steatorrhea at 1, 5, 10 and 20 years after diagnosis of CP were 4.27% (95% CI: 3.42%–5.34%), 12.53% (95% CI: 10.74%–14.59%), 20.44% (95% CI: 17.37%–23.98%) and 30.82% (95% CI: 20.20%–45.21%), respectively. Male gender (HR = 1.771, p = 0.004), diabetes (HR = 1.923, p < 0.001), alcohol abuse (HR = 1.503, p = 0.025) and pancreaticoduodenectomy (HR = 2.901, p < 0.001) were independent risk factors for steatorrhea while CP in adolescents (HR = 0.433, p = 0.009) was a protective factor. In conclusion, male gender, adult, diabetes, alcohol abuse and pancreaticoduodenectomy lead to increased risk of steatorrhea in CP patients.read more
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Diagnosis and Management of Chronic Pancreatitis: A Review.
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References
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Journal ArticleDOI
Relations between pancreatic enzyme outputs and malabsorption in severe pancreatic insufficiency.
TL;DR: To investigate the functioning reserve capacity of the exocrine pancreas, the relations of steatorrhea and creatorrhea to lipase and trypsin outputs in 17 patients with chronic pancreatic cancer are studied.
Journal Article
Course and outcome of chronic pancreatitis. Longitudinal study of a mixed medical-surgical series of 245 patients.
TL;DR: In both groups lasting relief from pain was correlated with the duration of the disease and was associated with marked pancreatic dysfunction; the 50% survival time in alcoholic chronic pancreatitis was 20-24 yr (after onset), thus markedly shorter than in nonalcoholic pancreatitis.
Journal ArticleDOI
Colorectal polypectomy and endoscopic mucosal resection (EMR): European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline
Monika Ferlitsch,Alan C. Moss,Cesare Hassan,Pradeep Bhandari,Jean-Marc Dumonceau,Gregorios A. Paspatis,Rodrigo Jover,Cord Langner,Maxime E. S. Bronzwaer,Kumanan Nalankilli,Paul Fockens,Rawi Hazzan,Ian M. Gralnek,Michael Gschwantler,Elisabeth Waldmann,Philip Jeschek,D Penz,D. Heresbach,Leon M G Moons,Arnaud Lemmers,Konstantina D. Paraskeva,Juergen Pohl,Thierry Ponchon,Jaroslaw Regula,Alessandro Repici,Matthew D. Rutter,Nicholas G. Burgess,Nicholas G. Burgess,Michael J. Bourke,Michael J. Bourke +29 more
TL;DR: ESGE recommends that the goals of endoscopic mucosal resection (EMR) are to achieve a completely snare-resected lesion in the safest minimum number of pieces, with adequate margins and without need for adjunctive ablative techniques.
Journal ArticleDOI
The different courses of early- and late-onset idiopathic and alcoholic chronic pancreatitis.
Peter Layer,Hironori Yamamoto,Ludwig Kalthoff,Jonathan E. Clain,Linda J. Bakken,Eugene P. DiMagno +5 more
TL;DR: There are two distinct forms of idiopathic chronic pancreatitis, both of which have initially and thereafter a long course of severe pain but slowly develop morphological and functional pancreatic damage, whereas patients with late-onset pancreatitis have a mild and often a painless course.
Journal ArticleDOI
Clinical and genetic characteristics of hereditary pancreatitis in Europe
Nathan Howes,Markus M. Lerch,William Greenhalf,Deborah D. Stocken,Ian O. Ellis,Peter Simon,Kaspar Truninger,Rudi Ammann,Giorgio Cavallini,Richard Charnley,Generoso Uomo,Miriam Delhaye,Julius Spicak,Brendan Drumm,Jan B.M.J. Jansen,Roger Mountford,David C. Whitcomb,John P. Neoptolemos +17 more
TL;DR: Symptoms in hereditary pancreatitis start in younger patients and endpoints take longer to be reached compared with other forms of chronic pancreatitis but the cumulative levels of exocrine and endocrine failure are much higher.