Risk Factors for Diabetes Mellitus in Chronic Pancreatitis: A Cohort of 2011 Patients
Jun Pan,Lei Xin,Dan Wang,Zhuan Liao,Jin-Huan Lin,Bai-Rong Li,Ting-Ting Du,Bo Ye,Wen-Bin Zou,Hui Chen,Jun-Tao Ji,Zhao-Hong Zheng,Liang-Hao Hu,Zhao-Shen Li +13 more
TLDR
The risk of developing DM in patients with CP is not only influenced by the development of biliary stricture and steatorrhea indicating disease progression, and inherent nature of study subjects such as male sex, but also by modifiable factors including alcohol abuse and distal pancreatectomy.About:
This article is published in Medicine.The article was published on 2016-04-01 and is currently open access. It has received 83 citations till now. The article focuses on the topics: Hazard ratio.read more
Citations
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Journal ArticleDOI
Patient and Disease Characteristics Associated With the Presence of Diabetes Mellitus in Adults With Chronic Pancreatitis in the United States
Melena D. Bellin,David C. Whitcomb,Judah Abberbock,Stuart Sherman,Bimaljit S. Sandhu,Timothy B. Gardner,Michelle A. Anderson,Michele D. Lewis,Samer Alkaade,Vikesh K. Singh,John Baillie,Peter A. Banks,Darwin L. Conwell,Gregory A. Cote,Nalini M. Guda,Thiruvengadam Muniraj,Gong Tang,Randall E. Brand,Andres Gelrud,Stephen T. Amann,Chris E. Forsmark,C. Mel Wilcox,Adam Slivka,Dhiraj Yadav +23 more
TL;DR: In this large multicenter cohort of patients with CP, exocrine insufficiency, calcifications, and pancreas surgery conveyed higher odds of having DM, however, the traditional ‘type 2 DM’ risk factors of obesity and family history were similarly important in conveying risk for DM.
Journal ArticleDOI
PROspective Evaluation of Chronic Pancreatitis for EpidEmiologic and Translational StuDies: Rationale and Study Design for PROCEED From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer.
Dhiraj Yadav,Walter G. Park,Evan L. Fogel,Liang Li,Suresh T. Chari,Ziding Feng,William E. Fisher,Chris E. Forsmark,Christie Y. Jeon,Aida Habtezion,Phil A. Hart,Steven J. Hughes,Mohamed O. Othman,Jo Ann Rinaudo,Stephen J. Pandol,Temel Tirkes,Jose Serrano,Sudhir Srivastava,Stephen K. Van Den Eeden,David C. Whitcomb,Mark Topazian,Darwin L. Conwell +21 more
TL;DR: The established cohort and biorepository will facilitate numerous analyses, leading to new strategies for diagnosis, methods to monitor disease progression, and treatment of CP, and provide the most accurate and reliable estimates to date on progression.
Journal ArticleDOI
Incidence of and risk factors for pancreatic cancer in chronic pancreatitis: A cohort of 1656 patients.
Lu Hao,Xiang-Peng Zeng,Lei Xin,Dan Wang,Jun Pan,Ya-Wei Bi,Jun-Tao Ji,Ting-Ting Du,Jin-Huan Lin,Di Zhang,Bo Ye,Wen-Bin Zou,Hui Chen,Ting Xie,Bai-Rong Li,Zhao-Hong Zheng,Teng Wang,Hong-Lei Guo,Zhuan Liao,Zhao-Shen Li,Liang-Hao Hu +20 more
TL;DR: The risk of pancreatic cancer is markedly increased in chronic pancreatitis patients compared with the general population, especially in patients with an older age at onset and a >60 pack-year smoking history.
Journal ArticleDOI
International consensus guidelines for surgery and the timing of intervention in chronic pancreatitis.
Marinus A. Kempeneers,Yama Issa,U. Ahmed Ali,Ryan Baron,Marc G. Besselink,M.W. Büchler,Mert Erkan,C. Fernandez-del Castillo,S. Isaji,J. R. Izbicki,Jörg Kleeff,Johanna Laukkarinen,Andrea Sheel,Toru Shimosegawa,David C. Whitcomb,John A. Windsor,Y. Miao,John P. Neoptolemos,Marja A. Boermeester +18 more
TL;DR: This international expert consensus guideline provides evidenced-based statements concerning key aspects in surgery and timing of intervention in CP to guide clinical practitioners and surgeons in the treatment of patients with CP.
Journal ArticleDOI
Antidiabetic Medications and Mortality Risk in Individuals With Pancreatic Cancer-Related Diabetes and Postpancreatitis Diabetes: A Nationwide Cohort Study.
TL;DR: Metformin promotes a survival benefit in individuals with PPDM but not PCRD, and reverse causality may play a role in the association between insulin use and mortality in PCRD.
References
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Diagnosis and Classification of Diabetes Mellitus
TL;DR: The chronic hyperglycemia of diabetes is associated with long-term damage, dys-function, and failure of differentorgans, especially the eyes, kidneys, nerves, heart, and blood vessels.
Journal ArticleDOI
Chronic pancreatitis: Diagnosis, classification, and new genetic developments
Babak Etemad,David C. Whitcomb +1 more
TL;DR: It is concluded that an adequate pancreatic biopsy must be the gold standard against which all diagnostic approaches are judged and the roles of endoscopic retrograde pancreatography, endoscopic ultrasonography, and magnetic resonance imaging are considered.
Journal ArticleDOI
Norepinephrine and Epinephrine Release and Adrenergic Mediation of Smoking-Associated Hemodynamic and Metabolic Events
TL;DR: Since significant smoking-associated increments, in pulse rate, blood pressure and blood lactate/pyruvate ratio, preceded measurable increments in plasma catecholamine concentrations, but were adrenergically mediated, these changes should be attributed to norepinephrine released locally from adrenergic axon terminals within the tissues rather than to increments in circulating catechlamines.
Journal ArticleDOI
Insulin resistance and cigarette smoking
Gerald M. Reaven,Y-D. Ida Chen +1 more
TL;DR: The findings show that chronic cigarette smokers are insulin resistant, hyperinsulinaemic, and dyslipidaemic compared with a matched group of non-smokers, and may help to explain why smoking increases risk of coronary heart disease.
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