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Risk for breast cancer development determined by mammographic parenchymal pattern.

John N. Wolfe
- 01 May 1976 - 
- Vol. 37, Iss: 5, pp 2486-2492
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TLDR
A classification of risk for developing breast cancer has been devised based solely on the appearance of the breast parenchyma by mammography by reviewing the mammograms of all women over the age of 30 who had been examined at Hutzel Hospital, Detroit.
Abstract
A classification of risk for developing breast cancer has been devised based solely on the appearance of the breast parenchyma by mammography. Four groups of patients were isolated. The study encompassed a five-year period and was done by reviewing the mammograms of all women over the age of 30 who had been examined at Hutzel Hospital, Detroit. The average time of followup would be approximately 2 1/2 years. Four groups had an incidence of developing breast cancer of 0.1, 0.4, 1.7, and 2.2. These parenchymal patterns are described and criteria for their identification are given.

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Journal ArticleDOI

Mammographic Density and the Risk and Detection of Breast Cancer

TL;DR: Extensive mammographic density is strongly associated with the risk of breast cancer detected by screening or between screening tests, and a substantial fraction of breast cancers can be attributed to this risk factor.
Journal ArticleDOI

Breast Density and Parenchymal Patterns as Markers of Breast Cancer Risk: A Meta-analysis

TL;DR: This review explains some of the heterogeneity in associations of breast density with breast cancer risk and shows that, in well-conducted studies, this is one of the strongest risk factors for breast cancer.
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A Tense Situation: Forcing Tumour Progression

TL;DR: The changing force that cells experience needs to be considered when trying to understand the complex nature of tumorigenesis.
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Extracellular Matrix Degradation and Remodeling in Development and Disease

TL;DR: Understanding the mechanisms of ECM remodeling and its regulation is essential for developing new therapeutic interventions for diseases and novel strategies for tissue engineering and regenerative medicine.
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Diagnostic Performance of Digital versus Film Mammography for Breast-Cancer Screening

TL;DR: The overall diagnostic accuracy of digital and film mammography as a means of screening for breast cancer is similar, but digital mammography is more accurate in women under the age of 50 years, women with radiographically dense breasts, and premenopausal or perimenopausal women.
References
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Journal ArticleDOI

A Study of Breast Parenchyma by Mammography In the Normal Woman and Those with Benign and Malignant Disease

John N. Wolfe
- 01 Aug 1967 - 
TL;DR: There is a difference of only a slight degree between the woman with clinically apparent mammary dysplasia such as adenosis and fibrocystic disease and the “normal” and that the abnormalities are developmental, with their highest incidence in the late teens and early twenties.
Journal ArticleDOI

Mammography: Ducts as a Sole Indicator of Breast Carcinoma1

John N. Wolfe
- 01 Aug 1967 - 
TL;DR: The purpose of this article is to describe and illustrate those cases in which abnormal ducts can lead to a correct diagnosis of breast cancer.
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