Role of mucosal injury in initiating recurrent aphthous stomatitis.
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TLDR
It is confirmed that mechanically induced injury of the oral mucosa may cause ulceration in people susceptible to aphthous stomatitis and such a procedure may therefore be helpful in identifying subsets of patients.Abstract:
The buccal mucosa of 30 patients with recurrent aphthous stomatitis and 15 healthy controls was injured by suture and penetration with a tenaculum and a hypodermic needle and each of the six puncture wounds produced monitored for up to seven days for the development of ulcers. Altogether 26 lesions were induced in 13 patients, whereas none occurred in the controls (p less than 0.001). Sutures caused most of the lesions (15), and those so induced had a mean maximum diameter of 2.3 mm and lasted for an average of four days. Ulcers induced mechanically were clinically indistinguishable from those usually seen in the patients, except that they were generally smaller and healed more quickly. These findings confirm that mechanically induced injury of the oral mucosa may cause ulceration in people susceptible to aphthous stomatitis. Such a procedure may therefore be helpful in identifying subsets of patients.read more
Citations
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Journal ArticleDOI
Recurrent Aphthous Stomatitis
TL;DR: A detailed review of the current knowledge of the etiology, pathogenesis, and managment of RAS is provided.
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Recurrent aphthous ulcers today: a review of the growing knowledge
Sirajedin S. Natah,Sirajedin S. Natah,Yrjö T. Konttinen,Nabil Enattah,Nureddin Ashammakhi,Keith A. Sharkey,Ritva Häyrinen-Immonen +6 more
TL;DR: Different aetiologies and mechanisms might be operative in the aetiopathogenesis of aphthous ulceration, but pain, recurrence, self-limitation of the condition, and destruction of the epithelium seem to be the ultimate outcomes.
Journal ArticleDOI
Number VI Recurrent aphthous stomatitis
TL;DR: Treatment of RAS remains unsatisfactory, as most therapies only reduce the severity of the ulceration and do not stop recurrence, but drugs, especially non-steroidal anti-inflammatory drugs and nicorandil can often control RAS.
Journal ArticleDOI
Oral mucosal disease: recurrent aphthous stomatitis.
Crispian Scully,Stephen Porter +1 more
TL;DR: Diagnosis is on clinical grounds alone, and must be differentiated from other causes of recurrent ulceration, particularly Behçet disease - a systemic disorder in which aphthous-like ulcers are associated with genital ulcers, and eye disease (particularly posterior uveitis).
Journal ArticleDOI
Recurrent aphthous stomatitis : an update
TL;DR: Management of this condition depends on the clinical presentation and symptoms and includes analgesic, antimicrobial, and immunomodulatory drugs.
References
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Journal ArticleDOI
Recurrent aphthous stomatitis. Clinical, therapeutic, histopathologic, and hypersensitivity aspects
TL;DR: Recurrent aphthae is often erroneously confused with herpes simplex infection and it may have clinical and histological aspects in common with Behcet's, Stevens-Johnson, and Reiter's syndrome.
Journal ArticleDOI
Autoimmunity in oral diseases, with special reference to recurrent oral ulceration.
TL;DR: This concept admits the possibility that antibodies can be stimulated not only by foreign substances, e.g. bacteria, but also by the body's own substances or 'self-antigens'.
Journal ArticleDOI
Bronchial Epithelium in Former Smokers
TL;DR: The most significant changes short of invasive carcinoma are lesions composed entirely of such atypical cells with cilia absent, and large numbers of such lesions occurred in the bronchial epithelium of men who had died of lung cancer, and almost as many were found in the lungs of heavy cigarette smokers.