Role of optic nerve imaging in glaucoma clinical practice and clinical trials.
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TLDR
Although optic disk stereophotography represents the standard for documentation of glaucomatous structural damage in practice and research trials, advances in computerized imaging technology provide useful measures that assist the clinician inglaucoma diagnosis and monitoring and offer considerable opportunity for use as efficacy endpoints in clinical trials.About:
This article is published in American Journal of Ophthalmology.The article was published on 2008-04-01 and is currently open access. It has received 88 citations till now. The article focuses on the topics: Optic disk & Stereophotography.read more
Citations
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Optical coherence tomography of the retina and optic nerve - a review
TL;DR: The spectral domain OCT became available, a new technique that allowed major improvements particularly regarding image acquisition speed and image resolution, and future studies will address how these major technological advances will impact the use of the OCT in research and clinical practice.
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Sensitivity and specificity of time-domain versus spectral-domain optical coherence tomography in diagnosing early to moderate glaucoma.
TL;DR: The sensitivity and specificity of various RNFL parameters using the Cirrus OCT for glaucoma with early to moderate visual field defects are excellent and are equivalent to Stratus OCT.
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Macular versus Retinal Nerve Fiber Layer Parameters for Diagnosing Manifest Glaucoma:A Systematic Review of Diagnostic Accuracy Studies
Francesco Oddone,Ersilia Lucenteforte,Manuele Michelessi,Stanislao Rizzo,Simone Donati,Mariacristina Parravano,Gianni Virgili +6 more
TL;DR: With the use of OCT, RNFL parameters are still preferable to macular parameters for diagnosing manifest glaucoma, but the differences are small, and direct comparative or randomized studies of OCT devices or OCT parameters and diagnostic strategies are essential.
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Diagnostic Ability of Fourier-Domain vs Time-Domain Optical Coherence Tomography for Glaucoma Detection
TL;DR: Cross-sectional peripapillary RNFL thickness measurements obtained using FD-O CT generated with the RTVue are greater than those obtained with TD-OCT and have similar diagnostic performance for glaucoma detection.
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The glaucoma research community and FDA look to the future: a report from the NEI/FDA CDER Glaucoma Clinical Trial Design and Endpoints Symposium.
TL;DR: The National Eye Institute (NEI), of the National Institutes of Health (NIH), and the Food and Drug Administration Center for Drug Evaluation and Research (FDA CDER) held a Symposium to discuss the possible use of new structural and functional endpoints for evaluating glaucoma therapies in clinical trials as discussed by the authors.
References
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The Ocular Hypertension Treatment Study: A Randomized Trial Determines That Topical Ocular Hypotensive Medication Delays or Prevents the Onset of Primary Open-Angle Glaucoma
Michael A. Kass,Dale K. Heuer,Eve J. Higginbotham,Chris A. Johnson,John L. Keltner,J. Philip Miller,Richard K. Parrish,M. Roy Wilson,Mae O. Gordon +8 more
TL;DR: Topical ocular hypotensive medication was effective in delaying or preventing the onset of POAG in individuals with elevated IOP, and clinicians should consider initiating treatment for individuals with ocular hypertension who are at moderate or high risk for developing POAG.
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The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma.
Mae O. Gordon,Julia A. Beiser,James D. Brandt,Dale K. Heuer,Eve J. Higginbotham,Chris A. Johnson,John L. Keltner,J. Philip Miller,Richard K. Parrish,M. Roy Wilson,Michael A. Kass +10 more
TL;DR: Baseline age, vertical and horizontal cup-disc ratio, pattern standard deviation, and intraocular pressure were good predictors for the onset of POAG in the OHTS and central corneal thickness was found to be a powerful predictor for the development ofPOAG.
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Comparison of glaucomatous progression between untreated patients with normal-tension glaucoma and patients with therapeutically reduced intraocular pressures
TL;DR: Intraocular pressure is part of the pathogenic process in normal-tension glaucoma and therapy that is effective in lowering intraocular pressure and free of adverse effects would be expected to be beneficial in patients who are at risk of disease progression.
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Ocular hypertension treatment study: Baseline factors that predict the onset of primary open-angle glaucoma
TL;DR: Baseline age, vertical and horizontal cup-disc ratio, pattern standard deviation, and intraocular pressure were good predictors for the onset of POAG in the OHTS and central corneal thickness was found to be a powerful predictor for the development ofPOAG.
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Optic Nerve Damage in Human Glaucoma: III. Quantitative Correlation of Nerve Fiber Loss and Visual Field Defect in Glaucoma, Ischemic Neuropathy, Papilledema, and Toxic Neuropathy
TL;DR: The pattern of atrophy in examples of toxic amblyopia, ischemic optic neuropathy and chronic papilledema differ from that of glaucoma, suggesting different mechanisms of damage in these conditions.