Journal ArticleDOI
Scleroderma-like lesions and the carcinoid syndrome.
TLDR
Patients with scleroderma-like lesions secondary to metastatic secreting carcinoid tumors are different in several ways from patients with progressive systemic sclerosis, and differences in end-organ (skin) response to exogenous serotonin creatinine sulfate suggest metabolic differences as well.Abstract:
Patients with scleroderma-like lesions secondary to metastatic secreting carcinoid tumors are different in several ways from patients with progressive systemic sclerosis. Scleroderma resulting from a carcinoid does not have an acrosclerotic distribution but develops first in dependent regions of the body following pronounced pitting edema. Raynaud's phenomenon is absent. Results of serological tests are negative. The typical internal organ changes of systemic sclerosis are not seen. Differences in end-organ (skin) response to exogenous serotonin creatinine sulfate suggest metabolic differences as well. It is probable that scleroderma arises by a different mechanism when associated with the carcinoid syndrome than when seen independently, and that this mechanism involves capillary permeability and tissue edema induced by serotonin or other active tumor metabolites.read more
Citations
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Platelet-derived serotonin links vascular disease and tissue fibrosis
Clara Dees,Alfiya Akhmetshina,Pawel Zerr,Nicole Reich,Katrin Palumbo,Angelika Horn,Astrid Jüngel,Christian Beyer,Gerhard Krönke,Jochen Zwerina,Rudolf Reiter,Natalia Alenina,Luc Maroteaux,Georg Schett,Oliver Distler,Jörg H W Distler +15 more
TL;DR: Blocking 5-HT2B receptor provides a therapeutic target for fibrotic diseases caused by activated platelet release of serotonin during vascular damage.
Journal ArticleDOI
Cancer in systemic sclerosis.
TL;DR: The frequency of cancer is increased in patients with SSc, and older age at diagnosis of SSc was a significant risk factor for cancer.
Journal ArticleDOI
Association of malignancy with diseases causing interstitial pulmonary changes.
TL;DR: A number of studies have shown a high incidence of lung cancer in patients with idiopathic pulmonary fibrosis compared to control subjects, and this trend occurs in other entities that affect the interstitial lung compartment, such as systemic sclerosis and sarcoidosis.
Clinical and laboratory studies
Tor-Øivind Gabrielsen,Inge Dale,Per Brandtzaeg,Per S. Hoel,Magne K Dr Fagerhol,Tore Eeg Larsen,Per Thune +6 more
Journal ArticleDOI
Development of a Scleroderma-like Illness during Therapy with L-5-Hydroxytryptophan and Carbidopa
E. M. Sternberg,Van Woert Mh,Simon N. Young,Magnussen I,H. Baker,S. Gauthier,C. K. Osterland +6 more
TL;DR: The data and studies in the literature suggest that two factors may be important in the pathogenesis of some scleroderma-like illness: high plasma serotonin and the abnormality associated with elevated kynurenine.
References
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Journal ArticleDOI
Systemic scleroderma, A clinical study of 727 cases.
TL;DR: A longterm clinical study of scleroderma is believed to be unique in the extremely large number of patients observed, and to add to knowledge of a poorly understood entity.
Journal ArticleDOI
Correlation of kynurenine excretion with liver tryptophan pyrrolase levels in disease and after hydrocortisone induction.
Kurt Altman,Olga Greengard +1 more
Journal ArticleDOI
Raynaud's disease, Raynaud's phenomenon, and serotonin.
Alfred Halpern,Paul H. Kuhn,Herbert E. Shaftel,Saul S. Samuels,Norman Shaftel,David Selman,Herbert G. Birch +6 more
TL;DR: Raynaud felt that the absence of any appreciable vascular obstacle was a common denominator, Beck in 1912 wrote that there is no vestige of a doubt that the direct, most active factor in Raynaud’s disease is the obliterating endarteritis.
Journal ArticleDOI
Dermal Fibrosis Following Subcutaneous Injections of Serotonin Creatinine Sulphate.
TL;DR: The present findings appear to lend some support to the hypothesis that serotonin causes the cardiac valvular fibrosis observed in patients with the carcinoid syndrome.