Journal ArticleDOI
Selective grignard-type carbonyl addition of alkenyl halides mediated by chromium(II) chloride
TLDR
Alkenyl iodide (or bromide) is readily reduced with CrCl2 is N,N-dimethylformamide at 25°C to gice the corresponding organochromium species which adds selectively to an aldehyde moiety without affecting the coexisting ketone or cyano group of the substrate.About:
This article is published in Tetrahedron Letters.The article was published on 1983-01-01. It has received 264 citations till now. The article focuses on the topics: Grignard reaction & Chromium(II) chloride.read more
Citations
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Large-scale applications of transition metal-catalyzed couplings for the synthesis of pharmaceuticals.
Javier Magano,Joshua R. Dunetz +1 more
Journal ArticleDOI
Carbon−Carbon Bond Formations Involving Organochromium(III) Reagents
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Tetrahydrofuran-containing macrolides: a fascinating gift from the deep sea.
TL;DR: Deep Sea Adriana Lorente,‡ Janire Lamariano-Merketegi,§,# and Mercedes Álvarez*,‡,⊥ †Institute for Research in Biomedicine, Barcelona Science Park, University of Barcelona, Baldiri Reixac 10, 08028 Barcelona, Spain
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Catalytic asymmetric synthesis of allylic alcohols and derivatives and their applications in organic synthesis.
TL;DR: The plethora of methods developed for the catalytic asymmetric synthesis of enantioenriched allylic alcohols, including dynamic kinetic resolution (DKR/DKAT), nucleophilic 1,2-addition to carbonyl groups, allylic substitution, oxidation of C-H bonds, and the addition of O nucleophiles to π systems are summarized.
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Bimetallic catalysis using transition and Group 11 metals: an emerging tool for C-C coupling and other reactions.
TL;DR: This Review gathers together these usually isolated topics in order to stimulate synergy between the bimetallic research coming from more basic organometallic studies and the more synthetic organic approaches to this chemistry.
References
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Journal ArticleDOI
Thermal decomposition of vinylic copper(I) and silver(I) organometallic compounds
TL;DR: In this paper, it was shown that free propenyl radicais are not intermediates in these thermal coupling re-ttctions, when interpreted in light of the known rate of inversion of configuration of vinylradicirls.
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Highly Selective Carbon-Carbon Bond Forming Reactions Mediated by Chromium(II) Reagents
TL;DR: A low valent chromium reagent is generated from chromium(III) chloride and a half mol of lithium aluminum hydride in tetrahydrofuran as mentioned in this paper, which behaves similarly to anhydrous chromium (II) chloride, which is commercially available, and reduces allylic halides to produce unisolable allylchromium species which add efficiently to aldehydes or ketones with high degree of stereo and chemoselectivity.
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Brom/Lithium-Austausch an Vinylbromiden mit 2 Moläquivv. tert-Butyllithium. Umsetzungen von Vinyllithiumverbindungen mit Hetero- und Kohlenstoff-Elektrophilen
Helmut Neumann,Dieter Seebach +1 more
TL;DR: In this paper, the authors discuss the usefulness of these reactions in the synthesis of carbonyl compounds and compare their usefulness with that of alternative recent methods, such as alkylation, silylation, sulfenylation, and oxygenation.