Journal ArticleDOI
Selective induction of DNA synthesis in T and B lymphocytes
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It is suggested that Con A-activated T cells can influence B cells to respond to Con A; whereas B cells by themselves cannot be activated by Con A, suggesting that LPS exerts a non-specific stimulatory effect on B cells.About:
This article is published in Cellular Immunology.The article was published on 1972-08-01. It has received 383 citations till now. The article focuses on the topics: Cytotoxic T cell & CD40.read more
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Book ChapterDOI
The interactions of lectins with animal cell surfaces.
TL;DR: This chapter discusses the interactions of lectins with animal cell surfaces, which have proven to be quite useful for clinical blood typing and structural studies of blood group substances, in analysis of the surface structure of normal and tumor cells, and so on.
Journal ArticleDOI
Potentiation of the t-lymphocyte response to mitogens ii. the cellular source of potentiating mediator(s)
Igal Gery,Byron H. Waksman +1 more
TL;DR: It is concluded that LAF stimulates both central and peripheral T lymphocytes and enhances their responses to other stimulants.
Book ChapterDOI
Bacterial endotoxins and host immune responses
David C. Morrison,John L. Ryan +1 more
TL;DR: This chapter discusses the nature of endotoxins and their interactions with cells of the immune system, leading to direct interaction of endotoxin with B lymphocytes leading to the formation of antibodies to endotoxin as well as a spectrum of other immunoglobulin molecules.
Journal ArticleDOI
Risk assessment in immunotoxicology. I. Sensitivity and predictability of immune tests.
Michael I. Luster,Christopher J. Portier,D. Gayla Pait,Kimber L. White,Chris Gennings,Albert E. Munson,Gary J. Rosenthal +6 more
TL;DR: It is indicated that the performance of only two or three immune tests are sufficient to predict immunotoxic compounds in rodents (greater than 90% concordance) and the tests that showed the highest association with immunotoxicity were the splenic antibody plaque forming cell response and cell surface marker analysis.
Journal ArticleDOI
Development of a testing battery to assess chemical-induced immunotoxicity: National toxicology program's guidelines for immunotoxicity evaluation in mice
Michael I. Luster,Albert E. Munson,Peter T. Thomas,Michael P. Holsapple,James D. Fenters,Kimber L. White,L.D. Lauer,Dori R. Germolec,Gary J. Rosenthal,Jack H. Dean +9 more
References
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Journal ArticleDOI
Plaque formation and isolation of pure lines with poliomyelitis viruses.
Renato Dulbecco,Marguerite Vogt +1 more
TL;DR: Pure virus lines were established by isolating the virus population produced in single plaques, which had the same morphological, serological, and pathogenic properties as the parent strain.
Journal ArticleDOI
A Theory of Self- Nonself Discrimination.
Peter A. Bretscher,Melvin Cohn +1 more
TL;DR: The foregoing requirements provide an explanation for self-nonself discrimination, which involves a specific deletion in the activity of both the humoral- and the carrier-antigen-sensitive cells.
Journal Article
The mitogenic effects of endotoxin and staphylococcal enterotoxin b on mouse spleen cells and human peripheral lymphocytes.
TL;DR: The effects of Salmonella endotoxin and staphylococcal enterotoxin B were examined in vitro on mouse and human lymphocyte populations from unsensitized subjects and attempts to detect stimulation of human lymphoid cells by endotoxin using various mammalian sera as augmentors were unsuccessful.
Journal ArticleDOI
Evidence for thymus-independent humoral antibody production in mice against polyvinylpyrrolidone and E. coli lipopolysaccharide
Birger Andersson,Henric Blomgren +1 more
TL;DR: It is concluded that thymus cells do not act as antigen-concentrating cells and that they play no detectable role for humoral antibody formation in the systems here examined, and that E. coli LPS could specifically enhance the antibody response of thymectomized mice against antigen-coated sheep erythrocytes.