Journal ArticleDOI
Semistarvation-induced hyperactivity compensates for decreased norepinephrine and dopamine turnover in the mediobasal hypothalamus of the rat.
TLDR
The combined influence of semistarvation and hyperactivity on central catecholamine turnover in the rat is discussed as an animal model for the effects of malnutrition and heavy exercise often observed in anorexia nervosa.Abstract:
Male Wistar rats were housed in running wheel cages and were restricted in their food intake, in order to reduce the initial body weight by 30% within 10 days. Rats increased their daily running up to distances between 7 and 11 km compared to the maximum 2.5 km in controls fed ad libitum. The hypothalamic noradrenaline (NE) turnover, as estimated by the concentration of the major metabolite MHPG, was significantly decreased in semistarved sedentary rats compared to controls. Hyperactivity resulted in marked elevation of NE turnover at all time points examined. Semistarvation-induced decreases of dopamine (DA) turnover as estimated by the concentrations of its major metabolite DOPAC, could also be compensated by hyperactivity. The circadian pattern of NE turnover parallels the pattern of running activity. MHPG levels at times of high activity were even higher than in controls fed ad libitum (p<0.01). The availability of the precursor tyrosine, as indicated by the ratio of plasma tyrosine to the large neutral amino acids, was significantly decreased in semistarvation (p<0.0001); hyperactivity caused a further decrease (p<0.001), indicating that tyrosine availability is not, under these conditions, a limiting factor for noradrenaline turnover. The combined influence of semistarvation and hyperactivity on central catecholamine turnover in the rat is discussed as an animal model for the effects of malnutrition and heavy exercise often observed in anorexia nervosa.read more
Citations
More filters
Journal ArticleDOI
Reinforcement value and substitutability of sucrose and wheel running: implications for activity anorexia
TL;DR: The results suggested that food-deprived rats were sensitive to qualitative changes in food supply (sucrose concentration) while continuing to defend a level of physical activity (wheel running), and the implications of the interrelationships of sucrose and wheel running for an understanding of activity anorexia.
Journal ArticleDOI
Exercise in food-restricted rats produces 2DG feeding and metabolic abnormalities similar to anorexia nervosa.
TL;DR: As predicted, 2DG reduced food intake in animals subjected to the phenomenon and this effect was related to reductions in plasma glucose and insulin under the conditions that prevailed at the time of injection.
Journal ArticleDOI
Activation of α2-adrenoceptors suppresses excessive wheel running in the semistarvation-induced hyperactive rat
TL;DR: It is concluded that semistarvation-induced hyperactivity can be blocked by alpha 2-agonists.
Journal ArticleDOI
Interacting Neural Processes of Feeding, Hyperactivity, Stress, Reward, and the Utility of the Activity-Based Anorexia Model of Anorexia Nervosa.
TL;DR: The basic neurobiology of feeding and hyperactivity seen in both ABA and AN are described, and the research on the role that stress-response and reward pathways play in modulating the homeostatic drive to eat and to expend energy are compiles.
Journal ArticleDOI
Neurotransmitter and hormonal background of hostility in anorexia nervosa.
Francesca Brambilla,Laura Bellodi,Cinzia Arancio,Daniela Limonta,Ettore Ferrari,Bruno Solerte +5 more
TL;DR: W hostility is higher than normal in anorexics, and its severity seems to be linked to the secretion of FT and not to the alterations in the 5-HT function.
References
More filters
Journal Article
Precursor control of neurotransmitter synthesis.
TL;DR: This relationship allows precursor administration to produce selective physiologic effects by enhancing neurotransmitter release from some but not all of the neurons potentially capable of utilizing the precursor for this purpose, and allows the investigator to predict when administering the precursor might be useful for amplifying a physiologic process, or for treating a pathologic state.
Journal ArticleDOI
Fasting, Feeding and Regulation of the Sympathetic Nervous System
Lewis Landsberg,James B. Young +1 more
TL;DR: The role of catecholamines in the regulation of metabolic processes has been recognized for over 50 years and they are known to influence metabolism in two major ways: they increase the rate of cel...
Journal ArticleDOI
Self-starvation of rats living in activity wheels on a restricted feeding schedule.
Journal ArticleDOI
Metabolism of normetanephrine-H3 in rat brain--identification of conjugated 3-methoxy-4-hydrophenylglycol as the major metabolite
TL;DR: It is suggested that deamination, reduction, and subsequent conjugation with sulfate is the primary route of metabolism of normetanephrine in rat brain and that norepinephrine is also metabolized to this sulfate conjugate.