Journal ArticleDOI
Serum Somatomedin Activity after Hypophysectomy and during Parturition in Fetal Lambs
M. W. Brinsmead,G. C. Liggins +1 more
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Somatomedins, detectable by sulfation factor activity (SFA) and/or somatomedin-like receptor activity (SmLRA), were measured in the serum of 72 normal fetal lambs of varying gestational ages and in 12 fetuses before and after hypophysectomy.Abstract:
Somatomedins, detectable by sulfation factor activity (SFA) and/or somatomedin-like receptor activity (SmLRA), were measured in the serum of 72 normal fetal lambs of varying gestational ages and in 12 fetuses before and after hypophysectomy. Three hypophysectomized fetal lambs were infused with GH and/or insulin. Three intact fetal lambs were infused with glucose. Parturition was induced by infusion of synthetic ACTH into 5 fetal lambs. SmLRA and SFA were compared to a pool of adult sheep serum arbitrarily designated 1.00 U/ml. Serum SmLRA correlated significantly with gestational age (r = 0.65; P P > 0.05). Serum SmLRA and SFA were unchanged by hypophysectomy of the fetus and GH infusion but were reduced by insulin infusion. Plasma SmLRA correlated negatively with plasma insulin during glucose infusion (r = -0.67; P < 0.05). ...read more
Citations
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Journal ArticleDOI
Insulin as a Growth Factor
David J. Hill,R. D. G. Milner +1 more
TL;DR: It can be concluded that insulin functions as a growth factor in both normal and abnormal development.
Journal ArticleDOI
4 Insulin and insulin-like growth factors/ somatomedins in fetal and neonatal development
TL;DR: This presentation has attempted to review the status of knowledge of the hormonal regulation of fetal and neonatal growth, and has placed particular emphasis on the roles of insulin and somatomedin in fetal growth.
Book ChapterDOI
Regulation of Fetal Growth
Peter D. Gluckman,G. C. Liggins +1 more
TL;DR: In the first half of pregnancy, genetic control is dominant and gives rise to relatively narrow limits of variability of patterns of fetal growth; in the second half ofregnancy, constraints and stimuli become increasingly important and give rise to greater variability of growth and of maturational milestones.
Journal ArticleDOI
The effects of biosynthetic insulin-like growth factor-1 supplementation on somatic growth, maturation, and erythropoiesis on the neonatal rat
Anthony F Philipps,Bengt Persson,Kerstin Hall,Mats Lake,Anna Skottner,Truls Sanengen,Vicki R. Sara +6 more
TL;DR: It is suggested that nutritional sufficiency may also be necessary for the full expression of somatomedin effects, as shown in the first demonstration in vivo of the anabolic effects of IGF-1 in rapidly growing neonatal rats.
Journal ArticleDOI
Endocrine regulation of fetal and postnatal meat animal growth.
Terry D. Etherton,R.S. Kensinger +1 more
TL;DR: Evidence is discussed which indicates that nutrient partitioning between muscle and adipose tissue can be altered by growth hormone administration in meat animals and that manipulation of systemic hormone concentrations and tissue sensitivity to hormones involved in growth and differentiation may result in means to manipulate fetal and postnatal growth and development.
References
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Journal ArticleDOI
Some Studies of the Protein-Binding of Steroids and Their Application to the Routine Micro and Ultramicro Measurement of Various Steroids in Body Fluids by Competitive Protein-Binding Radioassay
TL;DR: A 100-fold increase in sensitivity has now been achieved by using tritiated steroids in place of 14C-labeled steroids, by utilizing the CBG's of species other than man, and by using adsorption in Place of dialysis or gel filtration.
Journal ArticleDOI
Use of Polyethylene Glycol to Separate Free and Antibody-Bound Peptide Hormones in Radioimmunoassays†
TL;DR: A method of separation has been developed and applied to radioimmunoassays of insulin, parathyroid hormone, growth hormone and arginine vasopressin, which provides several advantages over the double-antibody precipitation method.
Book ChapterDOI
The mechanism of initiation of parturition in the ewe.
TL;DR: In this article, the authors discuss the mechanism of initiation of parturition in the ewe and describe a study that has been carried out on sheep to determine the extent to which the lamb shares in the mechanisms of initiation, to elucidate the means of its participation, and to unravel the intricate endocrine relationship between the conceptus and the mother.