Serum transferrin receptor and its ratio to serum ferritin in the diagnosis of iron deficiency.
TLDR
In anemic patients, TfR measurement is a valuable noninvasive tool for the diagnosis of iron depletion, and offers an attractive alternative to more conventional laboratory tests in the detection of depleted iron stores.About:
This article is published in Blood.The article was published on 1997-02-01 and is currently open access. It has received 828 citations till now. The article focuses on the topics: Ferritin & Soluble transferrin receptor.read more
Citations
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Journal ArticleDOI
Anemia of Chronic Disease
TL;DR: Advances in knowledge of the causes and management of the anemia of chronic disease are discussed.
Journal ArticleDOI
Iron deficiency anaemia
TL;DR: The clinical presentation, epidemiology, pathophysiology, diagnosis, and acute management of iron deficiency anaemia, and outstanding research questions for treatment are discussed.
Journal ArticleDOI
Biomarkers of Nutrition for Development (BOND)-Iron Review.
Sean Lynch,Christine M. Pfeiffer,Michael K. Georgieff,Gary M. Brittenham,Susan J. Fairweather-Tait,Richard F. Hurrell,Harry J. McArdle,Daniel J Raiten +7 more
TL;DR: A full appreciation of folate's history as a public health issue, its biology, and an overview of available biomarkers and their interpretation across a range of clinical and population-based uses are provided.
Journal ArticleDOI
The quantitative assessment of body iron.
TL;DR: In this article, a method for estimating body iron based on the ratio of the serum transferrin receptor to serum ferritin was described, which is useful clinically for monitoring iron status in those who are highly susceptible to iron deficiency.
Journal ArticleDOI
Guidelines for the management of iron deficiency anaemia
TL;DR: In this article, the lower limit of the normal range for the laboratory performing the test should be used to define anaemia and any level of anaemia should be investigated in the presence of iron deficiency.
References
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The meaning and use of the area under a receiver operating characteristic (ROC) curve.
TL;DR: A representation and interpretation of the area under a receiver operating characteristic (ROC) curve obtained by the "rating" method, or by mathematical predictions based on patient characteristics, is presented and it is shown that in such a setting the area represents the probability that a randomly chosen diseased subject is (correctly) rated or ranked with greater suspicion than a random chosen non-diseased subject.
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Serum transferrin receptor: a quantitative measure of tissue iron deficiency
TL;DR: The studies indicate that the serum receptor measurement is of particular value in identifying mild iron deficiency of recent onset and was a more sensitive and reliable guide to the degree of functional iron deficiency than either the FEP or MCV.
Journal Article
The use of relative operating characteristic (ROC) curves in test performance evaluation.
TL;DR: The construction and statistical uses of ROC analysis are demonstrated, its published applications in clinical pathology are reviewed, and its role in the decision analytic framework in laboratory medicine is commented on.
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The physiology of transferrin and transferrin receptors.
H A Huebers,C A Finch +1 more
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Laboratory diagnosis of iron-deficiency anemia: an overview.
Gordon H. Guyatt,Andrew D Oxman,Mahmoud A. M. Ali,Andrew R. Willan,William McIlroy,Christopher Patterson +5 more
TL;DR: Serum ferritin radioimmunoassay is an extremely powerful test for the diagnosis of iron-deficiency anemia and, appropriately interpreted, can be applied to the complete range of patients.