Journal ArticleDOI
Anemia of Chronic Disease
TLDR
Advances in knowledge of the causes and management of the anemia of chronic disease are discussed.Abstract:
New therapeutic strategies have emerged along with our understanding that disturbances of iron homeostasis, impaired proliferation of erythroid progenitor cells, and blunted erythropoietin response occur in anemia of chronic disease. This review discusses advances in our knowledge of the causes and management of the condition.read more
Citations
More filters
Journal ArticleDOI
Advances in metal-induced oxidative stress and human disease
Klaudia Jomová,Marian Valko +1 more
TL;DR: An overview of redox and non-redox metal-induced formation of free radicals and the role of oxidative stress in toxic action of metals is provided.
Journal ArticleDOI
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
Elizabeta Nemeth,Seth Rivera,Victoria Gabayan,Charlotte Keller,Sarah Taudorf,Bente Klarlund Pedersen,Tomas Ganz +6 more
TL;DR: These studies in human liver cell cultures, mice, and human volunteers indicate that IL-6 is the necessary and sufficient cytokine for the induction of hepcidin during inflammation and that the IL- 6-hepcid in axis is responsible for the hypoferremia of inflammation.
Journal ArticleDOI
Dissecting racial bias in an algorithm used to manage the health of populations
TL;DR: It is suggested that the choice of convenient, seemingly effective proxies for ground truth can be an important source of algorithmic bias in many contexts.
Journal ArticleDOI
Acute Skeletal Muscle Wasting in Critical Illness
Zudin Puthucheary,J Rawal,Mark J. W. McPhail,Mark J. W. McPhail,Bronwen Connolly,Bronwen Connolly,Gamunu Ratnayake,Pearl Chan,Nicholas S Hopkinson,Rahul Phadke,Tracy Dew,Paul S. Sidhu,Cristiana P. Velloso,John Seymour,Chibeza C. Agley,Anna Selby,Marie C. Limb,Lindsay M. Edwards,Kenneth Smith,Anthea Rowlerson,Michael J. Rennie,John Moxham,John Moxham,Stephen D. R. Harridge,Nicholas Hart,Nicholas Hart,Hugh Montgomery +26 more
TL;DR: A comprehensive prospective characterization of skeletal muscle wasting, defining the pathogenic roles of altered protein synthesis and breakdown was performed and skeletal muscle loss was determined through serial ultrasound measurement.
Journal ArticleDOI
The CRIT Study: Anemia and blood transfusion in the critically ill--current clinical practice in the United States.
Howard L. Corwin,Andrew Gettinger,Ronald G. Pearl,Mitchell P. Fink,Mitchell M. Levy,Edward Abraham,Neil R. MacIntyre,M. Michael Shabot,Mei-Sheng Duh,Marc J. Shapiro +9 more
TL;DR: The number of RBC transfusions a patient received during the study was independently associated with longer ICU and hospital lengths of stay and an increase in mortality and a nadir hemoglobin level of <9 g/dL was a predictor of increased mortality and length of stay.
References
More filters
Journal ArticleDOI
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
Elizabeta Nemeth,Seth Rivera,Victoria Gabayan,Charlotte Keller,Sarah Taudorf,Bente Klarlund Pedersen,Tomas Ganz +6 more
TL;DR: These studies in human liver cell cultures, mice, and human volunteers indicate that IL-6 is the necessary and sufficient cytokine for the induction of hepcidin during inflammation and that the IL- 6-hepcid in axis is responsible for the hypoferremia of inflammation.
Journal ArticleDOI
The effects of normal as compared with low hematocrit values in patients with cardiac disease who are receiving hemodialysis and epoetin.
Anatole Besarab,W K Bolton,J K Browne,Joan C. Egrie,Allen R. Nissenson,D M Okamoto,Steve J. Schwab,David A. Goodkin +7 more
TL;DR: In patients with clinically evident congestive heart failure or ischemic heart disease who are receiving hemodialysis, administration of epoetin to raise their hematocrit to 42 percent is not recommended.
Journal ArticleDOI
Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein.
Larry W. Moreland,Scott Baumgartner,Michael Schiff,Elizabeth A. Tindall,Roy Fleischmann,Arthur L. Weaver,Robert E. Ettlinger,Stanley Cohen,William J. Koopman,Kendall Mohler,Michael B. Widmer,Consuelo M. Blosch +11 more
TL;DR: In this three-month trial TNFR:Fc was safe, well tolerated, and associated with improvement in the inflammatory symptoms of rheumatoid arthritis.
Journal ArticleDOI
Anemia and blood transfusion in critically ill patients.
Jean Louis Vincent,Konrad Reinhart,Luciano Gattinoni,Lambert Thijs,A. R. Webb,Andreas Meier-Hellmann,Guy Nollet,Daliana Peres-Bota +7 more
TL;DR: This multicenter observational study reveals the common occurrence of anemia and the large use of blood transfusion in critically ill patients and provides evidence of an association between transfusions and diminished organ function as well as between transfusion and mortality.
Journal ArticleDOI
Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia
TL;DR: Older persons with anemia are common, albeit not severe, in the older population, and a substantial proportion of anemia is of indeterminate cause, which must be further investigated in older persons.