Sex Difference in Cue Strategy in a Modified Version of the Morris Water Task: Correlations between Brain and Behaviour
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TLDR
The study revealed that males outperformed females overall during training trials, relied on the geometric cue when the platform was moved and showed significant correlations between entorhinal cortex thickness and spatial memory performance.Abstract:
Background
Sex differences in spatial memory function have been reported with mixed results in the literature, with some studies showing male advantages and others showing no differences. When considering estrus cycle in females, results are mixed at to whether high or low circulating estradiol results in an advantage in spatial navigation tasks. Research involving humans and rodents has demonstrated males preferentially employ Euclidean strategies and utilize geometric cues in order to spatially navigate, whereas females employ landmark strategies and cues in order to spatially navigate.read more
Citations
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Sex differences in cognitive impairment and Alzheimer's disease
Rena Li,Meharvan Singh +1 more
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Sex differences in hippocampal cognition and neurogenesis.
Shunya Yagi,Liisa A.M. Galea +1 more
TL;DR: This review discusses sex differences in pattern separation, pattern completion, spatial learning, and links between adult neurogenesis and these cognitive functions of the hippocampus, and emphasizes the importance of including both sexes when studying genomic, cellular, and structural mechanisms of the hippocampal function.
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Sex Differences in Context Fear Generalization and Recruitment of Hippocampus and Amygdala during Retrieval
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Sex differences in behavioral outcome following neonatal hypoxia ischemia: Insights from a clinical meta-analysis and a rodent model of induced hypoxic ischemic brain injury
TL;DR: In this article, the authors examined published clinical studies from the past 20 years where long-term IQ outcome scores for matched groups of male and female premature infants were reported separately (IQ being the most common outcome measure).
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Age and gender-related differences in a spatial memory task in humans.
TL;DR: The results support that spatial memory becomes less accurate as the authors age and gender is an important factor influencing spatial orientation skills.
References
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Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat.
TL;DR: To the knowledge, this is the first demonstration of such short-term steroid-mediated synaptic plasticity occurring naturally in the adult mammalian brain.
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Gender differences in way-finding strategies: relationship to spatial ability and spatial anxiety
TL;DR: This article found that women were more likely to report attending to instructions on how to get from place to place and maintaining a sense of their own position in relation to environmental reference points than men.
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Variations in sex-related cognitive abilities across the menstrual cycle ☆
TL;DR: The results provide qualified support for the hypothesis that the high levels of gonadal steroids present at the luteal phase of the cycle may facilitate skills favoring females, but be detrimental to skills favoring males.
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Males and females use different distal cues in a virtual environment navigation task.
TL;DR: A computer-generated virtual environment is used to study sex differences in human spatial navigation and reveals that females rely predominantly on landmark information, while males more readily use both landmark and geometric information.
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Meta-analysis of sex differences in rodent models of learning and memory: a review of behavioral and biological data
TL;DR: The reliability of male advantages in spatial working and reference memory for rats across strains, protocols, ages and rearing environments is established and an important species dichotomy between rats and mice should be considered when transitioning from rat to mouse models.