Journal ArticleDOI
Sibling cell fate in the Drosophila adult external sense organ lineage is specified by prospero function, which is regulated by Numb and Notch
G.V. Reddy,Veronica Rodrigues +1 more
TLDR
It is shown that the homeodomain transcription factor Prospero (Pros) acts as an intrinsic signal for the specification of cell fates within the mechanosensory lineage.Abstract:
Specification of cell fate in the adult sensory organs is known to be dependent on intrinsic and extrinsic signals. We show that the homeodomain transcription factor Prospero (Pros) acts as an intrinsic signal for the specification of cell fates within the mechanosensory lineage. The sensory organ precursors divide to give rise to two secondary progenitors - PIIa and PIIb. Pros is expressed in PIIb, which gives rise to the neuron and thecogen cells. Loss of Pros function affects the identity of PIIb and neurons fail to differentiate. Pros misexpression is sufficient for the transformation of PIIa to PIIb fate. The expression of Pros in the normal PIIb cell appears to be regulated by Notch signaling.read more
Citations
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Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancer
TL;DR: The relevance of asymmetric cell divisions in various stem cell systems is summarized and why defects in asymmetrical cell division can lead to the formation of tumors are discussed.
Journal ArticleDOI
Revisiting the Drosophila microchaete lineage: a novel intrinsically asymmetric cell division generates a glial cell.
TL;DR: It is proposed that mechanosensory organ glial cells, the origin of which was until now unknown, are generated by the asymmetric division of pIIb cells, which provides the basis for future studies on how polarity and fate are regulated in asymmetrically dividing cells.
Journal ArticleDOI
Peripheral glia direct axon guidance across the CNS/PNS transition zone.
TL;DR: Testing the Drosophila model system concluded that peripheral glia prefigure the CNS/PNS transition zone and guide axons as they traverse this region.
Journal ArticleDOI
The brain tumor gene negatively regulates neural progenitor cell proliferation in the larval central brain of Drosophila.
TL;DR: The results provide evidence that the tumour suppressor brat negatively regulates cell proliferation during larval central brain development of Drosophila, and suggest that Prospero acts as a key downstream effector of brat in cell fate specification and proliferation control.
Journal ArticleDOI
Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation
Cheng Yu Lee,Ryan O. Andersen,Clemens Cabernard,Laurina Manning,Khoa D. Tran,Marcus J. Lanskey,Arash Bashirullah,Chris Q. Doe +7 more
TL;DR: It is concluded that Aurora-A and Numb are novel inhibitors of neuroblast self-renewal and that spindle orientation regulates neuroblastSelf-Renewal.
References
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Journal ArticleDOI
Targeted gene expression as a means of altering cell fates and generating dominant phenotypes.
Andrea H. Brand,Norbert Perrimon +1 more
TL;DR: The GAL4 system, a system for targeted gene expression that allows the selective activation of any cloned gene in a wide variety of tissue- and cell-specific patterns, has been designed and used to expand the domain of embryonic expression of the homeobox protein even-skipped.
Book
The Genome of Drosophila Melanogaster
TL;DR: Chromosomes: Deficiencies, Inversions, and Transposable Elements.
Journal Article
Notch signaling : Signal transduction
TL;DR: The Notch/Lin-12/Glp-1 receptor family mediates the specification of numerous cell fates during development in Drosophila and Caenorhabditis elegans and putative components of the signaling cascade are identified, including a conserved family of extracellular ligands and two cellular factors that may associate with the Notch Intracellular domain.
Journal ArticleDOI
The FLP recombinase of yeast catalyzes site-specific recombination in the Drosophila genome.
Kent G. Golic,Susan Lindquist +1 more
TL;DR: The site-specific recombination system of the yeast 2 micron plasmid, the FLP recombinase and its recombination targets (FRTs), into the genome of Drosophila, producing white-eyed and dark-red-eyed progeny.
Journal ArticleDOI
Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells.
TL;DR: It is determined by immunocytochemistry that numb is a membrane-associated protein which localizes asymmetrically to one-half of the predivisional SOP cell, and functions to determine the fates of the secondary precursors.