Significance of Circulating Tumor Cells Detected by the CellSearch System in Patients with Metastatic Breast Colorectal and Prostate Cancer.
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TLDR
Comparing the outcomes from three prospective multicenter studies investigating the use of CTC to monitor patients undergoing treatment for metastatic breast, colorectal, or prostate cancer is compared and the CTC definition used in these studies is reviewed.Abstract:
The increasing number of treatment options for patients with metastatic carcinomas has created a concomitant need for new methods to monitor their use. Ideally, these modalities would be noninvasive, be independent of treatment, and provide quantitative real-time analysis of tumor activity in a variety of carcinomas. Assessment of circulating tumor cells (CTCs) shed into the blood during metastasis may satisfy this need. We developed the CellSearch System to enumerate CTC from 7.5 mL of venous blood. In this review we compare the outcomes from three prospective multicenter studies investigating the use of CTC to monitor patients undergoing treatment for metastatic breast (MBC), colorectal (MCRC), or prostate cancer (MPC) and review the CTC definition used in these studies. Evaluation of CTC at anytime during the course of disease allows assessment of patient prognosis and is predictive of overall survival.read more
Citations
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Proceedings ArticleDOI
Detection, isolation, and capture of circulating breast cancer cells with photoacoustic flow cytometry
Kiran Bhattacharyya,Martin Njoroge,Benjamin S. Goldschmidt,Brian Gaffigan,Kyle Rood,John A. Viator +5 more
TL;DR: This method can not only be used to determine the disease state of the patient and the response to therapy, it can also be used for genetic testing and in vitro drug trials since the circulating cell can be captured and studied.
Dissertation
Exploring Markov modeling approaches for the health economic assessment of circulating tumor cells in the management of metastatic prostate cancer patients
TL;DR: Although, an indication that CTC-trap is a probable technology to use in the diagnostic pathway of prostate cancer, the evidence to substantiate this claim is difficult to obtain via Markov modeling, the results demonstrate the difficulty of Markov modeled approaches in early HTA in personalized (cancer) care.
Book ChapterDOI
Microfluidic Technologies for Deformability-Based Cell Sorting
TL;DR: The role of deformability in circulating cells, including erythrocytes, leukocytes, and CTCs, is discussed and a recently developed method to sort cells based on deformability using the microfluidic ratchet mechanism is described.
Journal ArticleDOI
Detection, manipulation and post processing of circulating tumor cells using optical techniques
TL;DR: Optical methods that have been used for CTC detection, manipulation and post processing are described and microfluidic systems seem to be more attractive for researchers due to their numerous advantages.
Proceedings ArticleDOI
Magnetic trapping with simultaneous photoacoustic detection of molecularly targeted rare circulating tumor cells
Chen-Wei Wei,Jinjun Xia,Ivan Pelivanov,Ivan Pelivanov,Xiaoge Hu,Xiaohu Gao,Matthew O'Donnell +6 more
TL;DR: Preliminary results show that the cells accumulate rapidly in the presence of an externally applied magnetic field produced by a dual magnet system, which appears promising for future preclinical studies on a small animal model and ultimate clinical detection of rare CTCs in the vasculature.
References
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The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited
TL;DR: It is now known that the potential of a tumour cell to metastasize depends on its interactions with the homeostatic factors that promote tumour-cell growth, survival, angiogenesis, invasion and metastasis.
Journal ArticleDOI
Circulating Tumor Cells, Disease Progression, and Survival in Metastatic Breast Cancer
Massimo Cristofanilli,G. Thomas Budd,Matthew J. Ellis,Alison Stopeck,Jeri Matera,M. Craig Miller,James M. Reuben,Gerald V. Doyle,W. Jeffrey Allard,Leon W.M.M. Terstappen,Daniel F. Hayes +10 more
TL;DR: The number of circulating tumor cells before treatment is an independent predictor of progression-free survival and overall survival in patients with metastatic breast cancer.
Journal ArticleDOI
Isolation of rare circulating tumour cells in cancer patients by microchip technology.
Sunitha Nagrath,Lecia V. Sequist,Shyamala Maheswaran,Daphne W. Bell,Daphne W. Bell,Daniel Irimia,Lindsey Ulkus,Matthew R. Smith,Eunice L. Kwak,Subba R. Digumarthy,Alona Muzikansky,Paula D. Ryan,Ulysses J. Balis,Ulysses J. Balis,Ronald G. Tompkins,Daniel A. Haber,Mehmet Toner +16 more
TL;DR: The CTC-chip successfully identified CTCs in the peripheral blood of patients with metastatic lung, prostate, pancreatic, breast and colon cancer in 115 of 116 samples, with a range of 5–1,281CTCs per ml and approximately 50% purity.
Journal ArticleDOI
Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases.
W. Jeffrey Allard,Jeri Matera,M. Craig Miller,Madeline Repollet,Mark Connelly,Chandra Rao,Arjan G.J. Tibbe,Jonathan W. Uhr,Leon W.M.M. Terstappen +8 more
TL;DR: The CellSearch system can be standardized across multiple laboratories and may be used to determine the clinical utility of CTCs, which are extremely rare in healthy subjects and patients with nonmalignant diseases but present in various metastatic carcinomas with a wide range of frequencies.
Journal ArticleDOI
Circulating Tumor Cells Predict Survival Benefit from Treatment in Metastatic Castration-Resistant Prostate Cancer
Johann S. de Bono,Howard I. Scher,R. Bruce Montgomery,Chris Parker,M. Craig Miller,H. Tissing,Gerald V. Doyle,Leon W.W.M. Terstappen,Kenneth J. Pienta,Derek Raghavan +9 more
TL;DR: CTC are the most accurate and independent predictor of OS in CRPC, and this data led to Food and Drug Administration clearance of this assay for the evaluation of CRPC.