Significance of Circulating Tumor Cells Detected by the CellSearch System in Patients with Metastatic Breast Colorectal and Prostate Cancer.
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TLDR
Comparing the outcomes from three prospective multicenter studies investigating the use of CTC to monitor patients undergoing treatment for metastatic breast, colorectal, or prostate cancer is compared and the CTC definition used in these studies is reviewed.Abstract:
The increasing number of treatment options for patients with metastatic carcinomas has created a concomitant need for new methods to monitor their use. Ideally, these modalities would be noninvasive, be independent of treatment, and provide quantitative real-time analysis of tumor activity in a variety of carcinomas. Assessment of circulating tumor cells (CTCs) shed into the blood during metastasis may satisfy this need. We developed the CellSearch System to enumerate CTC from 7.5 mL of venous blood. In this review we compare the outcomes from three prospective multicenter studies investigating the use of CTC to monitor patients undergoing treatment for metastatic breast (MBC), colorectal (MCRC), or prostate cancer (MPC) and review the CTC definition used in these studies. Evaluation of CTC at anytime during the course of disease allows assessment of patient prognosis and is predictive of overall survival.read more
Citations
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Journal ArticleDOI
Inertial Focusing for Tumor Antigen–Dependent and –Independent Sorting of Rare Circulating Tumor Cells
Emre Ozkumur,Ajay Shah,Jordan C. Ciciliano,Benjamin L. Emmink,David T. Miyamoto,Elena F. Brachtel,Min Yu,Min Yu,Pin-i Chen,Bailey Morgan,Julie Trautwein,Anya Kimura,Sudarshana Sengupta,Shannon L. Stott,Nezihi Murat Karabacak,Tom Barber,John R. Walsh,Kyle C. Smith,Philipp S. Spuhler,James P. Sullivan,Richard T. Lee,David T. Ting,Xi Luo,Xi Luo,Alice T. Shaw,Aditya Bardia,Lecia V. Sequist,David N. Louis,Shyamala Maheswaran,Ravi Kapur,Daniel A. Haber,Daniel A. Haber,Mehmet Toner +32 more
TL;DR: A multistage microfluidic device that is capable of sorting rare circulating tumor cells (CTCs) that are either positive or negative for the surface antigen epithelial cell adhesion molecule (EpCAM) and could be a promising addition to current diagnostic tools used in the clinic is developed.
Journal ArticleDOI
Evaluation and Prognostic Significance of Circulating Tumor Cells in Patients With Non–Small-Cell Lung Cancer
Matthew G Krebs,Robert Sloane,Lynsey Priest,Lee Lancashire,Jian-Mei Hou,Alastair Greystoke,Timothy H Ward,Roberta Ferraldeschi,Andrew Hughes,Glen Clack,Malcolm R Ranson,Caroline Dive,Fiona H Blackhall +12 more
TL;DR: CTCs are detectable in patients with stage IV NSCLC and are a novel prognostic factor for this disease, and further validation is warranted before routine clinical application.
Journal ArticleDOI
Size-selective collection of circulating tumor cells using Vortex technology
Elodie Sollier,Derek E. Go,James Che,Daniel R. Gossett,Sean O'Byrne,Westbrook M. Weaver,Nicolas Kummer,Matthew Rettig,Jonathan H. Goldman,Nicholas G. Nickols,Susan McCloskey,Rajan P. Kulkarni,Dino Di Carlo +12 more
TL;DR: This Vortex approach offers significant advantages over existing technologies, especially in terms of processing time, sample concentration, applicability to various cancer types, cell integrity and purity, and widespread adoption by clinicians and biologists who desire to enumerate CTCs.
Journal ArticleDOI
Circulating tumor cell technologies
TL;DR: As the understanding of CTC biology matures, CTC technologies will need to evolve, and some of the present challenges facing the field are discussed in light of recent data encompassing epithelial‐to‐mesenchymal transition, tumor‐initiating cells, and CTC clusters.
Journal ArticleDOI
Analysis of circulating tumor cells in patients with non-small cell lung cancer using epithelial marker-dependent and -independent approaches.
Matthew G Krebs,Jian-Mei Hou,Robert Sloane,Lee Lancashire,Lynsey Priest,Daisuke Nonaka,Timothy H Ward,Alison Backen,Glen Clack,Andrew Hughes,Andrew Hughes,Malcolm R Ranson,Fiona H Blackhall,Caroline Dive,Caroline Dive +14 more
TL;DR: In this paper, the authors compared an epithelial marker-dependent (CellSearch) and a marker-independent (isolation by size of epithelial tumor cells [ISET]) technology platform for the ability to identify CTCs.
References
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Journal ArticleDOI
Relationship of Circulating Tumor Cells to Tumor Response, Progression-Free Survival, and Overall Survival in Patients With Metastatic Colorectal Cancer
Steven J. Cohen,Cornelis J A Punt,Nicholas Iannotti,B. H. Saidman,Kert D. Sabbath,Nashat Y. Gabrail,Joel Picus,Michael A. Morse,Edith P. Mitchell,M. Craig Miller,Gerald V. Doyle,H. Tissing,Leon W.M.M. Terstappen,Neal J. Meropol +13 more
TL;DR: The number of CTCs before and during treatment is an independent predictor of PFS and OS in patients with metastatic colorectal cancer and Baseline and follow-up CTC levels remained strong predictors of P FS and OS after adjustment for clinically significant factors.
Journal ArticleDOI
Detection of Circulating Tumor Cells in Peripheral Blood of Patients with Metastatic Breast Cancer: A Validation Study of the CellSearch System
Sabine Riethdorf,Herbert A. Fritsche,Volkmar Müller,Thomas Rau,Christian Schindlbeck,Brigitte Rack,Wolfgang Janni,Cornelia Coith,Katrin Beck,Fritz Jänicke,S. Jackson,Terrie G. Gornet,Massimo Cristofanilli,Klaus Pantel +13 more
TL;DR: The CellSearch system enables the reliable detection of CTCs in blood and is suitable for the routine assessment of metastatic breast cancer patients in the clinical laboratory.
Journal ArticleDOI
Circulating Tumor Cells at Each Follow-up Time Point during Therapy of Metastatic Breast Cancer Patients Predict Progression-Free and Overall Survival
Daniel F. Hayes,Massimo Cristofanilli,G. Thomas Budd,Matthew J. Ellis,A. Stopeck,M. Craig Miller,Jeri Matera,W. Jeffrey Allard,Gerald V. Doyle,Leon W.W.M. Terstappen +9 more
TL;DR: In this paper, the authors reported that ≥5 circulating tumor cells (CTC) in 7.5 mL blood at baseline and at first follow-up in 177 patients with metastatic breast cancer (MBC) were associated with poor clinical outcome.
Journal ArticleDOI
Circulating tumor cells (CTC) detection: clinical impact and future directions.
TL;DR: Cytopathological examination of CTC/CTM, sensitively enriched from blood, represents a potentially useful alternative and can now be employed in routine analyses as a specific diagnostic assay, and be tested in large, blind, multicenter clinical trials.
Journal ArticleDOI
Circulating Tumor Cells versus Imaging—Predicting Overall Survival in Metastatic Breast Cancer
G. Thomas Budd,Massimo Cristofanilli,Mathew J. Ellis,Allison Stopeck,Ernest C. Borden,M. Craig Miller,Jeri Matera,Madeline Repollet,Gerald V. Doyle,Leon W.M.M. Terstappen,Daniel F. Hayes +10 more
TL;DR: Assessment of CTCs is an earlier, more reproducible indication of disease status than current imaging methods and may be a superior surrogate end point, as they are highly reproducible and correlate better with overall survival than do changes determined by traditional radiology.