Significance of Circulating Tumor Cells Detected by the CellSearch System in Patients with Metastatic Breast Colorectal and Prostate Cancer.
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TLDR
Comparing the outcomes from three prospective multicenter studies investigating the use of CTC to monitor patients undergoing treatment for metastatic breast, colorectal, or prostate cancer is compared and the CTC definition used in these studies is reviewed.Abstract:
The increasing number of treatment options for patients with metastatic carcinomas has created a concomitant need for new methods to monitor their use. Ideally, these modalities would be noninvasive, be independent of treatment, and provide quantitative real-time analysis of tumor activity in a variety of carcinomas. Assessment of circulating tumor cells (CTCs) shed into the blood during metastasis may satisfy this need. We developed the CellSearch System to enumerate CTC from 7.5 mL of venous blood. In this review we compare the outcomes from three prospective multicenter studies investigating the use of CTC to monitor patients undergoing treatment for metastatic breast (MBC), colorectal (MCRC), or prostate cancer (MPC) and review the CTC definition used in these studies. Evaluation of CTC at anytime during the course of disease allows assessment of patient prognosis and is predictive of overall survival.read more
Citations
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Inertial Focusing for Tumor Antigen–Dependent and –Independent Sorting of Rare Circulating Tumor Cells
Emre Ozkumur,Ajay Shah,Jordan C. Ciciliano,Benjamin L. Emmink,David T. Miyamoto,Elena F. Brachtel,Min Yu,Min Yu,Pin-i Chen,Bailey Morgan,Julie Trautwein,Anya Kimura,Sudarshana Sengupta,Shannon L. Stott,Nezihi Murat Karabacak,Tom Barber,John R. Walsh,Kyle C. Smith,Philipp S. Spuhler,James P. Sullivan,Richard T. Lee,David T. Ting,Xi Luo,Xi Luo,Alice T. Shaw,Aditya Bardia,Lecia V. Sequist,David N. Louis,Shyamala Maheswaran,Ravi Kapur,Daniel A. Haber,Daniel A. Haber,Mehmet Toner +32 more
TL;DR: A multistage microfluidic device that is capable of sorting rare circulating tumor cells (CTCs) that are either positive or negative for the surface antigen epithelial cell adhesion molecule (EpCAM) and could be a promising addition to current diagnostic tools used in the clinic is developed.
Journal ArticleDOI
Evaluation and Prognostic Significance of Circulating Tumor Cells in Patients With Non–Small-Cell Lung Cancer
Matthew G Krebs,Robert Sloane,Lynsey Priest,Lee Lancashire,Jian-Mei Hou,Alastair Greystoke,Timothy H Ward,Roberta Ferraldeschi,Andrew Hughes,Glen Clack,Malcolm R Ranson,Caroline Dive,Fiona H Blackhall +12 more
TL;DR: CTCs are detectable in patients with stage IV NSCLC and are a novel prognostic factor for this disease, and further validation is warranted before routine clinical application.
Journal ArticleDOI
Size-selective collection of circulating tumor cells using Vortex technology
Elodie Sollier,Derek E. Go,James Che,Daniel R. Gossett,Sean O'Byrne,Westbrook M. Weaver,Nicolas Kummer,Matthew Rettig,Jonathan H. Goldman,Nicholas G. Nickols,Susan McCloskey,Rajan P. Kulkarni,Dino Di Carlo +12 more
TL;DR: This Vortex approach offers significant advantages over existing technologies, especially in terms of processing time, sample concentration, applicability to various cancer types, cell integrity and purity, and widespread adoption by clinicians and biologists who desire to enumerate CTCs.
Journal ArticleDOI
Circulating tumor cell technologies
TL;DR: As the understanding of CTC biology matures, CTC technologies will need to evolve, and some of the present challenges facing the field are discussed in light of recent data encompassing epithelial‐to‐mesenchymal transition, tumor‐initiating cells, and CTC clusters.
Journal ArticleDOI
Analysis of circulating tumor cells in patients with non-small cell lung cancer using epithelial marker-dependent and -independent approaches.
Matthew G Krebs,Jian-Mei Hou,Robert Sloane,Lee Lancashire,Lynsey Priest,Daisuke Nonaka,Timothy H Ward,Alison Backen,Glen Clack,Andrew Hughes,Andrew Hughes,Malcolm R Ranson,Fiona H Blackhall,Caroline Dive,Caroline Dive +14 more
TL;DR: In this paper, the authors compared an epithelial marker-dependent (CellSearch) and a marker-independent (isolation by size of epithelial tumor cells [ISET]) technology platform for the ability to identify CTCs.
References
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Klaus Pantel,Sabine Riethdorf +1 more
TL;DR: Comparison of circulating tumor cell numbers before and after treatment is predictive for overall survival in patients with metastatic castration-resistant prostate cancer; this comparison is more helpful than prostate-specific antigen detection, according to a recent study.
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TL;DR: The magnetic gradient of the designed permanent magnet extracts magnetically labeled cells from any cell suspension to a desired plane, providing a homogeneous cell distribution and magnetically aligned objects in between the Ni lines.
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Flowcytometry - Principles and feasibility in transfusion medicine. Enumeration of epithelial derived tumor cells in peripheral blood
Leon W.M.M. Terstappen,Chandra Rao,Steven Gross,V. Kotelnikov,E. Racilla,Jonathan W. Uhr,A. J. Weiss +6 more
TL;DR: In following up the number of epithelial cells in the blood of patients with metastatic carcinoma of the breast, it was shown that it was well correlated with the activity of the disease.
Journal ArticleDOI
Circulating tumor cells (CTC) in newly diagnosed breast or colorectal cancers
Marco R. De Groot,M. Croonen,Walter J.B. Mastboom,Istvan Vermes,Arjan G.J. Tibbe,H. Tissing,Leon W.M.M. Terstappen +6 more
TL;DR: In this article, the presence of CTCs is associated with poor prognosis in patients with metastatic carcinomas, and the significance of the CTC at the time of diagnosis and after therapy is not known.