Journal ArticleDOI
Simvastatin modulates TNFα-induced adhesion molecules expression in human endothelial cells
Reads0
Chats0
TLDR
The present findings suggest that the benefits of statins in vascular disease may include the inhibition of expression of VCam-1 and ICAM-1 through effects on NF-kappaB.About:
This article is published in Life Sciences.The article was published on 2004-07-30. It has received 87 citations till now. The article focuses on the topics: Cell adhesion & Cell adhesion molecule.read more
Citations
More filters
Journal ArticleDOI
Research Progress on the Relationship between Atherosclerosis and Inflammation.
Yuhua Zhu,Xuemei Xian,Zhenzhen Wang,Yingchao Bi,Quangang Chen,Xufeng Han,Daoquan Tang,Renjin Chen +7 more
TL;DR: Atherosclerosis is a chronic inflammatory disease; unstable atherosclerotic plaque rupture, vascular stenosis, or occlusion caused by platelet aggregation and thrombosis lead to acute cardiovascular disease.
Journal ArticleDOI
Anti-inflammatory therapeutics for the treatment of atherosclerosis
Israel F. Charo,Rebecca Taub +1 more
TL;DR: The evidence supporting a role for inflammation in the pathogenesis of atherosclerosis is summarized, agents that are currently in the clinic are discussed and a perspective on the challenges faced in the development of drugs that target vascular inflammation is provided.
Journal ArticleDOI
Simvastatin induces cell cycle arrest and inhibits proliferation of bladder cancer cells via PPARγ signalling pathway.
Gang Wang,Rui Cao,Yongzhi Wang,Guofeng Qian,Han C. Dan,Wei Jiang,Lingao Ju,Min Wu,Yu Xiao,Xinghuan Wang +9 more
TL;DR: This study for the first time revealed that simvastatin inhibited bladder cancer cell proliferation and induced cell cycle arrest at G1/G0 phase via PPARγ signalling pathway.
Journal ArticleDOI
Statins and the vascular endothelial inflammatory response
John Greenwood,Justin C. Mason +1 more
TL;DR: The therapeutic effect of statins can be attributed, in part, to their action on the endothelium, which attenuate endothelial MHC class II expression, increase endothelial nitric oxide synthase and fibrinolytic activity, decrease leukocyte adhesion and transmigration, and enhance resistance to local injurious stimuli.
Journal ArticleDOI
Usefulness of statin pretreatment to prevent contrast-induced nephropathy and to improve long-term outcome in patients undergoing percutaneous coronary intervention.
Giuseppe Patti,Annunziata Nusca,Massimo Chello,Vincenzo Pasceri,Andrea D'Ambrosio,George W. Vetrovec,Germano Di Sciascio +6 more
TL;DR: Patients receiving statins before PCI have a significant decrease of CIN; this early protective effect translates into better long-term event-free survival, which may lend further support to utilization of statins as adjuvant pharmacologic therapy before PCI.
References
More filters
Journal ArticleDOI
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
TL;DR: A new method of total RNA isolation by a single extraction with an acid guanidinium thiocyanate-phenol-chloroform mixture is described, providing a pure preparation of undegraded RNA in high yield and can be completed within 4 h.
Journal ArticleDOI
Atherosclerosis — An Inflammatory Disease
TL;DR: Atherosclerosis is an inflammatory disease as discussed by the authors, and it is a major cause of death in the United States, Europe, and much of Asia, despite changes in lifestyle and use of new pharmacologic approaches to lower plasma cholesterol concentrations.
Journal Article
Atherosclerosis is an Inflammatory Disease
光宏 横山,Russell Ross +1 more
TL;DR: Despite changes in lifestyle and the use of new pharmacologic approaches to lower plasma cholesterol concentrations, cardiovascular disease continues to be the principal cause of death in the United States, Europe, and much of Asia.
Journal ArticleDOI
Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
Journal ArticleDOI
Current Perspectives on Statins
TL;DR: Proposed mechanisms include favorable effects on plasma lipoproteins, endothelial function, plaque architecture and stability, thrombosis, and inflammation, which may ultimately broaden their indication from lipid-lowering to antiatherogenic agents.